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Biomedical subjects

G Strauch

Publications and source records attributed to G Strauch.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Discordance between the short and standard metyrapone tests in isolated corticotropin insufficiency].

A 71-year-old man presented with clinical and common biological features of secondary adrenal insufficiency. Basal ACTH level was in the normal range. As it has been previously reported in ACTH deficiency, cortisol response to ACTH-test was normal. A single-dose metyrapone test, performed to confirm the diagnosis of adrenal insufficiency, gave unexpectedly normal results. However 11-desoxycortisol (compound S) response to standard-metyrapone test was subnormal ascertaining the diagnosis of ACTH-deficiency. Thus normal responses to single-dose metyrapone test do not imperatively exclude secondary adrenal failure.

Adrenal Insufficiency↗
PubMed1986

[Hyperthyroidism induced by amiodarone].

The incidence of amiodarone-induced thyrotoxicosis remains unclear, partly due to the difficulties encountered in making a firm diagnosis based on thyroid hormone levels. Amiodarone is known to inhibit thyroxine (T4) metabolism, thus bringing plasma T4 concentrations up to levels that may simulate T4 toxicosis. On the other hand, the iodine overload due to the drug itself may create true hyperthyroidism. The purpose of this paper is to suggest practical means of detecting thyrotoxicosis in patients on amiodarone and to discuss the treatment of this side-effect.

Amiodarone↗
PubMed1985

Which treatment for hyperprolactinemic females?

This paper has as its first aim the review of the present evidence for risks of chronic hyperprolactinemia as well as benefits and hazards of treatment tools. Among long-term risks, an increased incidence of breast cancer is unlikely while growth of pituitary adenomas occur in a minority. Though control of prolactin secretion can be obtained in most cases, cure of the disease is estimated to be nil with dopaminergic drugs and less than 50% with pituitary surgery. The efficacy of radiotherapy remains questionable. The choice of short- and long-term treatment is discussed according to specific clinical conditions.

Adenoma↗
PubMed1983

[Strategy for hormonal study in the arterial hypertension of acromegaly].

High blood pressure occurs in about 25 p. 100 of acromegalic patients. The mechanisms involved are unknown but an unusual incidence of Conn's syndrome has been reported in acromegaly. The development of hypertension may be favored by the chronic hydro-saline inflation dependent upon the growth hormone excess. Sodium inflation is likely to be responsible for abnormal responses to angiotensin II and its antagonists in normotensive acromegalics, which make the use of these agents inappropriate for the study of the renin-angiotensin-aldosterone system. The latter can be profitably explored by the measurement of hormonal blood levels which increase normally in response to Na deprivation and orthostatism. In cases of associated Conn syndrome, the urinary level of tetrahydro-aldosterone may be normal, aldosterone being metabolized through other pathways. This appears to be independent to growth hormone hypersecretion.

Acromegaly↗
PubMed1981

[Tumoral development of prolactin-secreting pituitary adenomas during pregnancy. Therapeutic approaches (author's transl)].

During pregnancy the volume of prolactin-secreting pituitary adenomas tends to increase dangerously for surrounding structures, especially the optic chiasma. When rapid growth occurs, at least three therapeutic approaches are possible: resection of the adenoma, temporization under monitoring and administration of bromocriptine. The latter treatment, which seems to be of particular value, was applied to a female patient and was followed by prompt regression of optic chiasma compression. However, as bromocriptine was given concurrently with chlormadinone acetate, this excellent result cannot be ascribed to bromocriptine alone.

Adenoma↗
PubMed1981

Blunt injuries to the carotid and vertebral arteries.

A small series of patients with blunt injury to eigher a carotid or vertebral artery is presented. In three patients the injury was recognized relatively promptly. Two underwent surgery and one was observed with reasonably good results. In two patients the injury was unrecognized, resulting in death in one patient and in a severe, fixed, long-term neurologic deficit in the other. It appears likely that reconstruction may be the treatment of choice in any patient with angiographically proven injury unless coma or severe dense hemiplegia is present.

Accidents, Home↗
PubMed1977

[Dynamics of hormonal modifications induced by bromocryptin during hyperprolactinemia].

In a group of 16 females and 2 males with hypogonadism and hyperprolactinemia, bromocriptine was found to suppress prolactin (PRL) high levels within one day without further significant lowering during a 3 weeks longitudinal survey. The usually effective dosage was 5 mg per day. On the contrary, sex hormones did not vary initially and increased secondarily only in those patients resuming gonadal activity. The changes were either cyclical or heterogenous when the first cycle was anovulatory. This latter situation could sometimes but not always be attributed to persistent hyperprolactinemia. Menstruation resumed in 11 patients. Persistance of hypogonadism in the remainder could be explained by incomplete PRL reduction in one case and probability of previous hypothalamo-pituitary damage in six. The latter hypothesis was based in part on impaired gonadotropins responses to LH RH which were not modified by the treatment.

Adolescent↗
PubMed1977

Hormonal changes induced by bromocriptine (CB-154) at the early stage of treatment.

Fifteen female patients with amenorrhea and hyperprolactinemia were studied 1 to 3 times daily during the first 4 days of treatment with bromocriptine (2.5 mg b.i.d). Normal PRL levels were reached within one day in 12 while the mean value for the whole group showed no further significant decrease. Estradiol, LH and FSH levels did not vary significantly at this stage even in those 10 patients who subsequently resumed menstruation.

Adult↗
PubMed1977

Reversible plasma and red blood cells volumes increases in acromegaly.

Plasma volume (PV) and red blood cells volume (RBCV) were measured in 76 normotensive acromegalic patients (42 males and 34 females) and compared with those of 28 controls on the basis of body surface. In untreated males PV and RBCV were significantly higher than in normals (P less than 0.001) and total blood volume (TBV) was above the normal range in 85%. Untreated females also showed an elevated PV but had significantly lower RBCV than the male patients. The only vascular volume of the patients with correlated significantly with the body weight or surface was RBCV in females. One to five studies were done after treatment in 52 patients and analyzed as a function of plasma GH levels. Plasma volume reverted to the normal range (males) or was significantly lower than in untreated patients (females) in the groups of patients with normal GH levels while RBCV normalized at higher GH concentrations. At similar GH levels, treated patients without pituitary failure (n = 35) or given T4 and/or cortisol substitution for hypopituitarism showed similar vascular volumes. The plasma volume and TBV in both sexes and RBCV in males was significantly correlated with Log 10 GH levels. It is concluded from these data and other experimental evidence that endogenous GH hypersecretion is responsible for the reversible PV and RBCV increases frequently found in acromegalic patients.

Acromegaly↗
PubMed1976

[Properties of anti-LH-RH serums induced by 2 different immunogens].

Several anti-LH RH antisera have been raised in Rabbits given as immunogen the synthetic decapeptide linked to bovine serum albumin by carbodiimide or bis-diazotized benzidine. Antibodies obtained with CDI as a coupling agent showed the highest titers and affinities enabling measurement of LH RH levels lower than 1 pg/tube. The specificity of the antisera, particularly toward 13 fragments of the molecule, were similar irrespective of the immunogen used.

Animals↗
PubMed1976

The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man.

Reverse T3 (3,3',5'-triiodothyronine, rT3), a major product of the peripheral monodeiodination of thyroxine (T4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rT3 concentration similar to that frequently observed in patients with nonthyroidal illness. No changes in basal serum T4, T3, TSH and prolactin concentrations, nor in the T3, TSH and prolactin responses to iv TRH were observed during rT3 administration. These findings suggest that physiologic increases in serum rT3 concentration probably do not inhibit T4 to T3 conversion or the anterior pituitary TSH and prolactin responses to thyrotropin-releasing hormone (TRH).

Adult↗
PubMed1976

[The antigenic properties of human prolactin (author's transl)].

The antigenic properties of human prolactin (HPr) were studied using various methods of radio-immuno assay. The homologous system, the difficulty of which resides in the preparation of the tracer, easily permits measurement of physiological levels. In this systems, blood prolactin in the monkey, has an antigenicity comparable with that of human prolactin, whereas growth hormone and human chorionic somatotropin have feeble or nil antigenic relationship with HPr. Human, sheep and pig prolactins have variable antigenic cross-reactions depending on the immune serum used. These antigenic cross reactions may be applied to the isolation of amniotic prolactin Human blood prolactin has several components of different molecular weight, but antigenicity comparable with that of pituitary HPr.

Animals↗