Search PubMed⌕ Search

Biomedical subjects

G Storme

Publications and source records attributed to G Storme.

At least 55 records · Page 3Linked to original sources
PubMed1993

Experience with high dose chemotherapy and autologous bone marrow transplantation in testicular cancer.

Carboplatin based HDCT followed by ABMT produces reasonable response rates (40-60%) and some durable remissions in patients with advanced and cisplatin resistant testicular cancer. Patients eligible for such an approach are those with primary refractory or recurrent disease and low probability for salvage by conventional dose regimens. The use of recombinant human growth factors and peripheral stem cell transplantation will probably reduce the toxicity and mortality of HDCT.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

Testis tumors.

Explore the source record for details and available documents.

Adolescent↗
PubMed1992

Routine clinical on-line portal imaging followed by immediate field adjustment using a tele-controlled patient couch.

We have evaluated the fluoroscopic on-line portal imaging (OPI) system developed by Siemens (Beamview-1, Concord, CA, U.S.A.) in routine clinical radiotherapy, involving the treatment of 883 fields (559 patient set-ups for treatment) on 21 patients. The image was typically generated by delivering 10 monitor units when used in single exposure or 1-2 monitor units on a large open field followed by 8-10 monitor units on the actual field when double exposure was used. Comparison between the portal image and the simulator film was done by eye. A region of tolerance was drawn on the simulator film and the field edges on the portal image had to project within this region. If this criterion was not met, adjustments followed by verification portal images were done before the remaining field dose was delivered. If possible, these adjustments were performed by moving the patient couch by remote control. The image quality was insufficient for evaluation in 75/883 (8.5%) fields. The abovementioned criterion was not met in 95/808 (11.8%) of the evaluable fields (26/559 patient set-ups were not evaluable). Of the 533 evaluable patient set-ups, 92 had to be adjusted (17.2%) including three (pelvic irradiations) set-ups that were adjusted on both field irradiated during the same radiotherapy session. In one case an incorrect tray (with wrong blocks) was detected and replaced. In one case (a 5.5 x 6.0 cm rectangular larynx field) the x and y axis of the field were interswitched. In one case incorrect focusing of a block was shown by the portal image. To make adjustments, the couch longitudinal position was changed 20 times (range -10 to +15 mm). The lateral position was changed 73 times (range -15 to +16 mm). The height position was changes 6 times (range -7 to +6 mm). Diaphragma rotation changes were performed 5 times (1 degree). The fraction of treatment time that was related to the use of OPI was 30.7% median (mean 32.4%, S.D. 14.1%). The range was 4.1 to 78.6%. On the basis of calculations assuming no OPI would have been used, field treatment time was increased by a median of 44.2% (mean 55.8%; S.D. 41.2%) by using OPI. The fraction of monitor units (fraction of the dose) to generate a satisfactory image was 10% median.(ABSTRACT TRUNCATED AT 400 WORDS)

Head and Neck Neoplasms↗
PubMed1991

Prediction of severe late complications in fractionated, high dose-rate brachytherapy in gynecological applications.

The pertinence of different points and volumes, proposed for reporting and prediction of complications in classical low dose-rate brachytherapy, was tested for high dose-rate, fractionated gynecological applications. A group of patients experiencing complications (especially rectal) was compared with a group treated without complications. We found that neither single reference points nor combinations of them are good predictors of late complications (p greater than 0.5). The same applies for the dose prescribed in point A. In contrast, volume calculations proved to be highly reliable, both in single applications as well as in cumulative calculations. It is concluded that, within the given treatment schedule, volumes up to 300 cm3 (as defined by ICRU report 38) can be treated safely.

Brachytherapy↗
PubMed1991

Radiotherapy in squamous cell esophageal cancer.

As the classical surgical treatment of squamous cell esophageal carcinoma is associated with poor 5-year survival rates and high operative mortality, radiotherapy and chemotherapy are being used as adjuvant or alternative primary treatments. The authors present their view on several therapeutic approaches and describe their irradiation technique.

Carcinoma, Squamous Cell↗
PubMed1991

Esophageal cancer.

The authors invited eminent Belgian specialists to report on their experience in esophageal cancer. A summary is given of the most striking features of their reports.

Combined Modality Therapy↗
PubMed1990

Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma.

A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presence of membrane-bound neurosecretory granules in the cells established the neuroendocrine nature of the tumour. In addition, the tumour was found to produce calcitonin, somatostatin and carcino-embryonic antigen (CEA). Calcitonin and somatostatin were also secreted. On the basis of this particular marker constellation the tumour closely resembles medullary thyroid carcinoma. Review of the recent literature on carcinoids of the larynx reveals immunoreactivity for calcitonin and CEA in a high percentage of cases.

Brain Neoplasms↗
PubMed1989

Rectal cancer: a summary.

The authors summarize the most important conclusions of a multicentric multidisciplinary review on rectal cancer in Belgium.

Belgium↗
PubMed1986

Quantitative study of liver metastases from colon cancer in rats after treatment with cyclosporine A.

Liver metastases were produced in syngeneic BD IX rats by intraportal injection of colon cancer cell aggregates. The cells originated from the DHD/K12 cell line, derived from a 1,2-dimethylhydrazine (CAS: 540-73-8)-induced colon adenocarcinoma in BD IX rats. The animals received either cyclosporine A (CSA) or the excipients alone (control) through daily gastric intubation during 6 weeks. Multiple and very large hepatic metastases were observed early in 100% of the CSA-treated rats. The mean tumor volume was approximately 2,000 times higher in the CSA-treated group than in the controls (P less than .01). Survival time in the CSA-treated group was shortened (P less than .01) by generalized metastatic disease. Easy production of metastasis from colon cancer in 100% of the animals and precise estimation of tumor volume may prove useful for future therapeutic studies of secondary hepatic disease.

Adenocarcinoma↗
PubMed1985

Fatal pulmonary toxicity by the association of radiotherapy and medroxyprogesterone acetate.

This report describes a fatal pneumonitis occurring in a breast cancer patient while on adjuvant treatment with radiotherapy and medroxyprogesterone acetate. The clinical and radiologic features, as well as the timing of this pneumonitis, make a radiation pneumonitis more than probable. A radiation pneumonitis was also observed in other patients treated in the same way. Medroxyprogesterone acetate thus seems to act as a radiosensitizer since no such effects were seen in patients treated with radiotherapy alone. The radioenhancing effect is not limited to the lungs, since radioesofagitis was also encountered in similarly treated patients.

Aged↗
PubMed1984

Lower motor neuron disease in a patient with Hodgkin's disease treated with radiotherapy.

A case of lower motor neuron disease after extended field irradiation for cervical stage IA nodular sclerosing Hodgkin's disease is reported. Recurrence of Hodgkin's disease is excluded and other diagnostic possibilities are discussed. We compared this case with twenty-four similar cases reported in the literature after irradiation of the spinal cord for Hodgkin's disease or other neoplasms. Special features included the relatively advanced age of the patient, the long latency period, a premonitory CK-rise and reversibility. The entity is considered to be a very rare and relatively benign complication of spinal cord irradiation important to recognize as an entity in order to avoid extensive reevaluation.

Electromyography↗
PubMed1981

The effect of a liquid elemental diet on cell proliferation in the colon of rats.

A liquid elemental diet (Vivonex) was given to rats for 6 days while control animals received a normal diet. At the end of the experiment each animal received one intraperitoneal injection of tritiated thymidine at 8 a.m. Animals from each group were killed hourly during the first 24 h after the injection and the proliferative activity was studied by autoradiography of the mucosa of the colon using the labeled mitoses-wave method. The epithelial cell proliferation was significantly decreased in the colon of the Vivonex-fed animals.

Animals↗
PubMed1981

Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro.

The anti-invasive effect of microtubule inhibitors and other growth inhibitors was examined in confrontations of aggregates of mouse fibrosarcoma cells (MO4) with fragments of embryonic chick heart. The microtubule inhibitors Nocodazole and methyl [5-(2-(4-fluorophenyl)-1,3-dioxolan-2-yl)-1H-benzimidazole-2-yl] carbamate at 1 microgram/ml inhibited invasion. 5-Fluorouracil at 1 microgram/ml, mitomycin C at 0.1 microgram/ml and ionizing radiation at 50 Gy permitted invasion of fibrosarcoma cells into the heart tissue. These results suggest that tumors, the growth of which is effectively controlled, might continue to invade.

Animals↗
PubMed1981

Influence of cells number on directional migration of MO4 cells in vitro.

The diameter of the circular area covered by MO4 cells explanted as a spheroid on glass is used as an index of directional migration. MO4 cells, the proliferation of which is inhibited by 5-fluorouracil or ionizing radiation can perform directional migration, indicating that directional migration and proliferation are basically unrelated cellular activities. In non-proliferating populations the distance of directional migration appears to increase with increasing volume of the original spheroid, indicating that directional migration is influenced by the cell number. Stimulation of directional migration is also obtained by explanting a second spheroid in the center of the area covered by cells from a first spheroid. Comparison of directional migration of cells from irradiated spheroids with that from spheroids in presence of 5-fluorouracil, shows that apart from the cell number, volume, degree of spread, number and type of intercellular contacts also influence directional migration.

Animals↗