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Biomedical subjects

G Stehle

Publications and source records attributed to G Stehle.

43 records · Page 3Linked to original sources
PubMed1983

Disposition of human fibrinopeptide A in normal and nephrectomized rabbits.

The distribution, elimination, and metabolism of human fibrinopeptide A (FPA) were studied in normal and nephrectomized rabbits. The activity of 125-I-labeled desamino-tyrosyl human FPA (DAT-FPA) was followed over 4 hours after i.v. administration. Results show that in normal rabbits (n = 10) DAT-FPA is eliminated from plasma in four phases with half-lives of 30 sec, 3.5 min, 15 min, and 90 min. The distribution of 123-I-labeled DAT-FPA in plasma was determined in 15 control rabbits with scintigraphy over 2 hours. DAT-FPA was distributed primarily in the cardiovascular system, liver, and kidneys. In some animals minimal radioactivity was detected over the gall bladder. Radioactivity accumulated rapidly in the urinary bladder, approximately 50% being recorded after 15 min and 90% after 120 min. In the heart area radioactivity decreased with half-lives of 25 sec, 7.5 min, 25 min, and 180 min. Nephrectomized rabbits had similar initial fast distribution of DAT-FPA after administration of 125-I-labeled (n = 10) and 123-I-labeled peptide (n = 10). The estimated half-life of the slow component was in the order of several hours. The results of the scintigraphic and gel chromatographic studies show that FPA is primarily excreted in the urine. Previously reported half-lives of FPA reflect distribution rather than steady state conditions.

Animals↗
PubMedDate not supplied

The use of computerized risk assessment for personal instruction in the primary prevention of ischaemic heart disease in a Japanese Automated Multiphasic Health Testing and Services Center.

The major objectives of ningen dock, or multiphasic health testing and services, have been moving from secondary prevention to primary prevention. The main reason for this is that recently the majority of the diseases involved have been chronic diseases which develop slowly and without visible symptoms--often the patient is unaware of the fact that he has a disease until the disease reaches an advanced stage. Of course such diseases, since they exhibit few or no symptoms, are hard to detect. Secondary preventive care becomes difficult in such a situation, and primary preventive care is even more difficult. The major diseases of this type at present are neoplastic and arteriosclerotic diseases. Secondary prevention, leading to early detection, has proved more effective in treating cases of neoplastic diseases, while primary prevention, with its consequent reduction of risk factors, has proved to be more useful in dealing with arteriosclerotic diseases. It is therefore highly recommended that computers installed for health testing be utilized for evaluating risk factors and presenting the results to the examinees through colour displays and other devices such as primary care instructions for them. It is relatively easy now to collect time series data and store them in computers. For people who have no symptoms or complaints, a combination of personal and group instructional methods is necessary for carrying out primary care health instructions.

Computers↗