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Biomedical subjects

G Stauch

Publications and source records attributed to G Stauch.

36 records · Page 2Linked to original sources
PubMed1984

Oncogenic activity of the BK type of human papova virus in inbred rat strains.

The oncogenicity of the human polyomavirus BK (BKV) was tested in newborn inbred rats. It was found that the tumor rate was negatively correlated with the levels of T antibody 3 months after inoculation and the frequency of animals with detectable T antibodies 1.5 months after inoculation. By contrast, no influence of viral HI titers on the tumor rates was found. Thymectomy of animals resulted in most experiments in increased tumor rates. Inoculation with BKV of animals later than 24 hours after birth yielded a decrease of tumor rates. The results obtained suggest that T antibody titers present at a critical time after inoculation are associated with low oncogenicity of BKV. The oncogenicity of BKV was comparatively tested in rat strains possessing the allele "l" or the allele "a", respectively. The oncogenicity was significantly higher in rats with the allele "l" than in rats with the allele "a". Rats with the allele "l" showed lower T antibody response than rats with the allele "a". These differences could be explained by the finding that cells of "a" origin showed in vitro a higher percentage of T antigen bearing cells than did cells of a strain possessing the allele "l". In comparison to previous results obtained with BKV inoculated outbred WISTAR rats, the oncogenicity of comparable BKV doses in inbred rats was generally higher and the latency period of tumor manifestation shortened.

Animals↗
PubMed1984

Distribution of polyoma virus in the organs of newborn Wistar rats after subcutaneous inoculation.

Polyoma virus of the Stuart Eddy strain was tritium-labelled by cultivating the virus in phosphate free Hepes buffered medium in presence of tritium labelled nucleotide triphosphates. The distribution of labelled virus in the organs and in the blood of newborn Wistar rats was examined at graded time intervals from two hours until 40 days after inoculation. The highest amounts of virus per organ was refound in the liver and the highest amount per mg organ weight in the spleen. The virus concentration in most organs exceeded by far the concentration found in the blood, indicating adsorption of virus in these organs. It was found that the distribution of tritium in the target organs for tumor appearance (kidneys and brain) did not differ basically from that in the non-target organs. As a consequence, the distribution of virus in the organs does not explain the fact that the kidneys and the brain are the predilection sites for tumor induction. Tritium labelling did not measurably influence the oncogenicity, infectivity and hemagglutinating activity of the virus.

Animals↗
PubMed1982

Aortic valve replacement and ascending aorta replacement in ankylosing spondylitis: report of three surgical cases and review of the literature.

Out of 887 consecutive patients who underwent aortic valve replacement between January 1976 and December 1981 at Hannover Medical School Hospital, 3 patients had severe aortic valve insufficiency associated with ankylosing spondylitis (Morbus Bechterew). One of them had huge aneurysmatic dilatation of the ascending aorta and successfully underwent replacement of the ascending aorta by a vascular prosthesis. Microscopical examination of the resected aortic wall showed characteristic findings of aortitis in ankylosing spondylitis. The 3 patients are in good clinical condition at 5 and 6 months, and 2 1/2 years, respectively, after uneventful surgery. It is concluded that aortic valve replacement in patients with ankylosing spondylitis can be performed feasibly and clinical results have been satisfactory. The risk of aneurysmatic dilatation of the ascending aorta resulting from aortitis associated with ankylosing spondylitis is emphasized.

Aorta↗
PubMed1981

Oncogenic activity of the BK type of human papova virus in newborn Wistar rats.

The oncogenic potential of the human papova virus BK (= BKV) has been examined in newborn Wistar rats. 12 of 37 animals inoculated with BKV s.c. and 7 of 40 animals inoculated with BKV i.c. developed tumors of various histological types. The latency periods ranged from 6 to 18 months. The BKV etiology of tumors was supported by detection of BKV T antigen in cells of established tumor lines by means of indirect immunofluorescence. No tumors appeared in animals given injections of saline instead of virus. BKV T antibodies were detected in sera of 100 per cent of animals bearing tumors but no in sera of control animals. Only 3 of 77 BKV infected and none of the control animals developed spontaneous tumors (adenomas).

Animals↗
PubMed1981

[Juvenile polyp in the small bowel (author's transl)].

A single case of a solitary juvenile polyp of the small bowel is presented in a 10 month old infant which produced a jejuno-jejunal intussusception. A review of the literature failed to show a similar case. The pathology of the polyp is discussed.

Humans↗
PubMed1980

Antioncogenic activity of influenza virus on polyoma virus induced renal and brain tumors in newborn Wistar rats.

Simultaneous inoculation of newborn Wistar rats with intact A/PR 8/34 (HON 1) influenza virus and the S.E. strain of polyoma virus resulted in significant reduction of the rates of both kidney sarcomas and brain tumors in comparison to controls given polyoma virus, only. This antioncogenic activity (AOA) of influenza virus was observed independently whether or not influenza and polyoma virus were injected on different sites or were inoculated as a combined vaccine. Ether-treated A/PR 8/34 influenza virus was found to have also AOA. However, in one experiment a significant AOA was demonstrated with respect to brain tumors, only, and not for the rate of renal sarcomas. In addition, the influenza strain A/Hong Kong/1/68 (H3N2) was found to have AOA.

Animals↗
PubMed1977

[Surgical treatment of radiation injuries of the intestinal tract after radiotherapy of malignant tumors].

From 1962-1975 in our hospital 44 patients were operated because of complications of the bowel after irradiation of malignant tumors. 3 patients were operated in the region of subsequent irradiation. While at the small intestine stenoses were the most frequent complication, at the great gut fistula of rectum, colon sigmoideum or vagina besides stenoses were frequent. The time between irradiation and operation differed between 5 weeks and 22 years. The peak of frequency in the region of the great gut was seen about the first year after termination of irradiation, in the region of the small intestine about the second year. Among the operations of the small intestine resection predominates, at the great gut colostomy. Half of the patients were without complications in the postoperative course. 10 patients died postoperatively, 4 of them of peritonitis. In 3 cases suture insufficiency was verified, in 2 further cases this was doubtful. 36 of 44 patients were without carcinoma at the time of operation or control examination. 16 patients survived 5 years or more.

Adult↗