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Biomedical subjects

G Smith

Publications and source records attributed to G Smith.

At least 919 records · Page 51Linked to original sources
PubMed1975

The bioavailability of carbamazepine.

Two aspects of the correlation of plasma carbamazepine level with drug dose in patients taking carbamazepine tablets indicated the possibility that the drug may be incompletely and variably absorbed from the alimentary tract of man. To investigate this possibility, pharmacokinetic studies were undertaken in six volunteers, who were given increasing single doses of carbamazepine in tablet form at appropriate intervals. These studies gave evidence of slow, and probably incomplete, absorption of carbamazepine. After administration of carbamazepine in a specially-prepared solution to 5 of the subjects, rapid absorption of the drug occurred, and in 4 subjects more drug was absorbed than when the same normal dose was given as tablets. It was concluded that the pharmaceutical formulation of carbamazepine tablets limits the bioavailability of the drug, and that problems may arise if the bioavailability of the drug is to be increased.

Biological Availability↗
PubMed1974

Ward design in relation to postoperative wound infection: 3.

The wound infection rates, nasal carriage rates, and nasal colonization rates were studied in a recently built surgical unit for two years when it was first opened. Five years later a further two-year period of study was undertaken.Judging by the incidence of postoperative wound infection, as far as both Staphylococcus pyogenes and Gram-negative organisms are concerned, there is no evidence that the environment has become less safe with use over the seven-year period since opening.

Bacteria↗