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Biomedical subjects

G Simon

Publications and source records attributed to G Simon.

At least 307 records · Page 17Linked to original sources
PubMed1979

[Adrenalin and cardiac output in pregnancy (author's transl)].

The heart rate performance, cardiac output and catecholamine excretion were observed at rest in the ergometer test (40 min at 50 watts) in a group of 8 pregnant women whose case history and clinical record did not reveal any abnormal findings, during the course of pregnancy (20th, 28th and 36th weeks of pregnancy) as well as 2 and 12 weeks post partum. It was found that the cardiac output increased, dependent upon the heart rate, the stroke volume remaining approximately constant (max. + 60%) during pregnancy, compared with the controls post partum. There is a close linear correlation (r = 0.983) between the measured heart rates and the corresponding excretion of epinephrine (adrenalin) with the urine at rest and under load. It may be assumed that there is a causative link between the increase in secretion of catecholamine by the mother and the well-known change in cardiac output during pregnancy.

Adult↗
PubMed1979

[Arteriitis temporalis--a major disease developing in advance age (author's transl)].

Arteriitis temporalis, a disease that was largely unknown in the early fifties, has gained importance in recent years. In the past ten years 32 patients suffering from arteriitis temporalis were diagnosed and treated both in the eye hospital and in the rheumatic-cardiological hospital of the Berlin-Buch Municipal Hospital. The following clinical findings were essential for the diagnosis: advanced or old age of the patient, massive headache in the temporal and/or occipital regions, myalgia primarily in the shoulders and the neck that responded relatively poorly to treatment, reduced eyesight, loss of weight and decrease in vitality. Extremely high BSR, an increased amount of alpha-2 and an increased level of alkaline phosphatase were most important among the laboratory findings. Corticosteroids have proved to be the medicine of choice for treating this condition.

Aged↗
PubMed1978

[Echocaridographic measurements of left ventricle, heart volume, and maximal oxygen uptake (author's transl)].

Echocardiograms, radiological heart volume and datas by treadmill-exercis of 50 endurance athlets were studied. There was a highly significant correlation between radiological heart volume and left ventricular dimension as well as left ventricular volume including stroke volume. Other good relations were found between echocardiographic measurements and maximal oxygen uptake. These findings of left ventricular echocardiographic dimensions compared with heart volume and oxygen uptake support the value of this method and permit its use in the analysis of physiological and pathologic changes.

Adolescent↗
PubMed1978

Radiographic appearance of the chest in emphysema.

Accuracy of the radiologic diagnosis of emphysema was assessed in 696 patients from whose lungs paper-mounted whole-lung sections had been made. Emphysema was diagnosed radiographically primarily on the basis of arterial deficiency. In addition, lung length, lung width, size of the retrosternal space, heart size, and diaphragm position were recorded from the chest films. Recognition of emphysema was poor when radiographs of inadequate quality were included (anteroposterior films or films from patients with acute or chronic lung disease). When these films were excluded, only occasional radiographs from patients without emphysema or with mild emphysema were thought to have emphysema radiologically. Of the patients with moderately severe and severe emphysema, 41% were diagnosed as having emphysema, as were two-thirds of those with the most severe grade of emphysema. For a given grade of emphysema, the radiologic diagnosis of emphysema was made more frequently when patients had severe chronic airflow obstruction. Emphysema was usually most severe in the zones of the lung in which emphysema was radiologically apparent. Centrilobular emphysema was usually present when emphysema was diagnosed radiologically in the upper zones of the lung, and panacinar emphysema was usually present when emphysema was diagnosed in the lower zones. Lung length and the size of the retrosternal space increased, the level of the diaphragm lowered, heart size decreased, and lung width was unchanged as emphysema became more severe. Lung length and diaphragm level were the most discriminating measurements, followed by size of the retrosternal space. No combination of radiologic variables was found that recognized emphysema better than the subjective diagnosis of emphysema based on arterial deficiency. Radiologic lung dimensions are related to stature; for given stature these measurements are larger in men and women.

Diagnostic Errors↗
PubMed1978

[Echocardiographic diagnosis of thrombotic deposits in acute endocarditis (author's transl)].

This report describes the echocardiographic features seen in 6 patients with valvular vegetations as documented by autopsy or surgery. 4 mitral, 3 aortic and 1 tricuspid valves were investigated using M-mode echoscan(n = 8). Characteristic findings observed were non-uniform thickening of the typical valve pattern in sytole and diastole without restriction of valve motion. In 7 cases the exact echocardiographic localization of valvular vegetation was confirmed in situ, whereas localization of vegetation in tricuspid valve disease was uncomplete.

Acute Disease↗
PubMed1977

Effect of beta adrenoceptor antagonists on baroreceptor reflex sensitivity in hypertension.

High-pressure baroreceptor reflex sensitivity (BRS) was estimated by measuring the reflex heart rate response to pharmacologic elevation of blood pressure (phenylephrine, 150 to 200 microgram intravenously) in 18 patients with essential hypertension on two occasions: after a 4-wk placebo period and after 9 wk of incremental doses of oral timolol (20, 40, and 60 mg daily). On placebo, measurements were performed both before and after propranolol (0.2 mg/kg intravenously). The level of cardiac vagal inhibition, estimated by the heart rate change after atropine (0.04 mg/kg intravenously), was similar in placebo and on timolol, thereby permitting comparisons of BRS. BRS on placebo (before and after propranolol) correlated with BRS on timolol ( r = 0.87 and 0.90, p less than 0.001), attesting to the reproducibility of BRS measurements. BRS was unchanged by either short-term (propranolol) or long-term (timolol) beta adrenoceptor inhibition. Results were similar in responders (n = 10), whose mean arterial blood pressure on timolol fell by 10 mm Hg or more, and in nonresponders. The findings do not provide evidence for a change in gain of the baroreceptor reflex arc under conditions of short- or long-term beta adrenoceptor inhibition.

Adult↗
PubMed1977

The plain chest radiograph in infants with an isolated ventricular septal defect.

The plain chest radiographic features of 43 infants with a ventricular septal defect are described. All were under 1 year of age, and cardiac catheter studies confirmed that they had an isolated ventricular septal defect (VSD), so that the RV pressure, size of the shunt and the pulmonary vascular resistance could be related to the radiographic appearances. The radiographs of a number of normal infants of similar age were available for comparison. Four patterns were seen in those with a VSD. In group 1 the radiograph appeared normal. In group 2 there was dilatation of the pulmonary artery and the proximal lung vessels, while in group 3 only the proximal lung vessels were dilated. In group 4 only some of the hilar and proximal lung vessles were dilated, so that the blood distribution appeared uneven.

Cardiac Catheterization↗
PubMed1977

Studies in chronic allergic bronchopulmonary aspergillosis. 2. Radiological findings.

The characteristics and the incidence of changes in plain chest radiographs were analysed in detail in 50 asthmatic patients with chronic allergic bronchopulmonary aspergillosis in whom the diagnosis had been made from 2 to 25 years previously (mean duration 10-9 years). One thousand two hundred and forty-two chest radiographs, an average of about two per year per patient, were reviewed. Two hundred and sixty-seven acute episodes of transient shadows (a mean of 5-3 per patient), mostly homogeneous consolidations and band-like shadows, were recorded throughout the period of follow-up. Features of overinflation were present in 21 patients in the first radiograph and in 17 in the last, the decrease being attributed to the effects of permanent lung damage due to the allergic aspergillosis. Permanent changes, such as tubular and ring shadows, loss of vascular shadows, and lobar shrinkage were recorded in 41 patients at the start and in 49 at the end of the follow-up. The tubular shadows were found in 28 patients in the first radiograph and in 45 in the last, whereas ring shadows were seen in 18 and 30 patients respectively. Half of the episodes of consolidation and atelectasis left permanent changes, mainly ring shadows, as seen in the last radiograph. Of the band-like shadows, 32% were found to be followed by the subsequent appearance of tubular shadows. Statistically significant correlations were found between the duration of aspergillosis, the number of transient shadows throughout the period of follow-up, the extent of the permanent shadows, and the reduction of gas transfer factor at the time of the final follow-up.

Aspergillosis↗
PubMed1977

Studies in chronic allergic bronchopulmonary aspergillosis. 4. Comparison with a group of asthmatics.

A comparison is made of lung function tests and radiographic findings in 20 asthmatic patients with allergic bronchopulmonary aspergillosis paired in terms of sex, age, and duration of asthma with 20 other asthmatics in whom the diagnosis of aspergillosis was excluded in order to see if the aspergillosis causes more lung damage. One hundred per cent of the patients with aspergillosis and 75% of the patients with asthma alone showed a significantly reduced forced expiratory volume in one second (FEV1) before bronchodilator. All the patients in the two groups had a significantly reduced maximal expiratory flow at 50% vital capacity breathing air (V50air) but the severity of the reduction was statistically greater in the aspergillosis group. Reversibility in FEV1 of 15% and more was found in 50% of patients with asthma alone as against 31% of patients with aspergillosis. The degree of reversibility of FEV1 was also statistically greater in patients with asthma alone. Improvement of less than 20% of V50 after helium-oxygen breathing was found in 33% of the patients with asthma alone and in 75% of the patients with aspergillosis. Patients with aspergillosis also showed significantly (0-001 less than P less than 0-01) more reduced gas transfer factor. Radiological features of overinflation were as common in the two groups. Tubular and ring shadows were found in 95% and 60% respectively of patients with aspergillosis as against 45% and 15% of patients with asthma alone.

Adult↗