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Biomedical subjects

G Simon

Publications and source records attributed to G Simon.

At least 271 records · Page 15Linked to original sources
PubMed1981

Effect of static and dynamic exercise on heart volume, contractility, and left ventricular dimensions.

Echocardiographic measurements in 90 successful athletes were compared with data from untrained subjects and patients with hypertension and cardiomyopathy. The athletes represented sports disciplines requiring predominantly static exercise and power training (weight lifters, hammer-throwers, shot putters) and dynamic or endurance exercise (middle and long distance runners, cyclists, nordic skiers, rowers). The left ventricular end-diastolic diameter in well-trained endurance athletes was increased from the normal mean of 47.8 to 53.6 mm. The relationship of ventricular wall thickness to end-diastolic diameter was not affected. With static training, an increase of the end-diastolic diameter in relation to body weight did not occur, but there was a definite increase of septal and posterior wall thickness with an altered ratio between end-diastolic diameter and wall thickness. The ratio stroke volume:heart volume was increased in endurance athletes, but decreased in power athletes. The shortening fraction was not altered by these various forms of training. The ejection fraction was increased in endurance athletes whereas power-trained athletes showed a moderate decrease. There was no indication of myocardial damage in power- or endurance-trained athletes. The critical threshold that is associated with damage is apparently not exceeded during athletic training.

Blood Pressure↗
PubMed1980

Qualitative and quantitative determination of drotaverine metabolites in rat bile.

After oral and intravenous administration of drotaverin-14C its metabolites were determined in rat bile. Three major metabolites were identified by tlc. All the metabolites appeared in conjugated form. No unchanged drotaverine was detectable in the bile, except after treatment with doses much in excess of the therapeutic range. The ratio of major metabolites to unchanged product was determined by two-dimensional densitometry using a Telechrom Video Densitometer.

Administration, Oral↗
PubMed1980

[Effects of beta-adrenergic blockade on hemodynamic parameters obtained by right heart catheter and echocardiography (author's transl)].

Echocardiographic and flow-directed catheter studies were performed on nine normal male volunteers to investigate the hemodynamic effects of beta-adrenergic blockade at rest and during exercise. The beta-receptor blockade induced inhibition of sympathetic drive led to a reduced myocardial contractility with raised pulmonary capillary pressure and a reduced shortening fraction during exercise. Stroke volume and cardiac output were reduced by 20--30%. There was a correlation between the measurements of stroke volume by echocardiography and by catheter (r = 0.76, p < 0.001), a stronger relationship was demonstrated in the measurement of cardiac output (r = 0.93, p < 0.001). In spite of raised pressures and reduced myocardial contractility there was no increase in enddiastolic left ventricular diameter. In addition to the Frank-Starling mechanism further pharmacological effects must be assumed to explain the observed effects of beta-adrenergic blockade.

Adolescent↗
PubMed1980

The effect of the steroid muscle relaxant pipecurium bromide on the acetylcholinesterase activity of red blood cells in vitro.

The acetylcholinesterase (AchE) inhibitory effect of a muscle relaxant 2 beta,16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha,17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan), was studied in vitro. The inhibition of AchE activity of human red blood cells, expressed as pI50, was 3.99, whereas that of serum cholinesterase (ChE) was 4.33. The AchE inhibitor action was reversible. The inhibition was not influenced by the combined administration of promethazine or atropine. The combined effect of pipecurium bromide and of some other diamino-azasteroid agent proved to be additive. Pipecurium bromide showed mixed-type inhibitory effect both on AchE and ChE.

Acetylcholinesterase↗
PubMed1980

[Echocardiographic values of healthy children in relation to ergometric performance (author's transl)].

The results of echocardiographic and ergometric studies on 22 children are presented. These children were involved in a daily lesson of gymnastics, swimming or rollerskating of one hour duration. Depending on the exhaustion during ergometry, the maximal parameters showed the same results as known from the literature. There were also no different results of echocardiographic values compared with weight or body surface related data of normal subjects. Normal values for echocardiographic data are presented and discussed with parameters of the maximal performance of the children. From that it is concluded that these sport activities do not influence the dimensions of the heart and its function because of the low intensity and short duration of the additional training lessons in contrast to the high spontaneous motoric activities of children.

Body Surface Area↗
PubMed1980

[Nerve lesions following injuries of the upper limbs in childhood (author's transl)].

A total of 93 cases of nerve lesions in the limbs in children is reported. After blunt trauma (n = 53), there was most often damage to the ulnar nerve (n = 28), especially in the area of the elbow joint, followed by the radial nerve (n = 14) and the median nerve (n = 11). Causes were primary pressure and scar compression following fractures of the elbow and forearm, where ventral re-siting and/or neurolysis were necessary in serious denervation processes. Among the cutting injuries (n = 40), the lesions in the area of the underside of the wrist severing the ulnar and median nerves, more rarely the radial nerve, are particularly mentioned. They have a good prognosis following microsurgery. Independent of their localisation, the following have a poor prognosis: all crushing injuries, multiple injuries, multilation lesions and non-visible stretching and tearing in the area of the plexus.

Arm↗
PubMed1979

[Echocardiography during ergometric exercise (author's transl)].

Radiological heart volume estimations and echocardiographic studies were performed on 30 male and 15 female middle distance athletes at rest, during supine ergometric exercise at 10 and 100 Watt and 1 minute after excerise. During exercise, there is an increase in cardiac output, in the small hearts of 6%, in the large hearts of 16%, due to a small enddiastolic increase and an associated decrease in the endsystolic left ventricular diameter. At rest and at 50 Watt, the cardiac output, corrected for body surface area, was practically the same for all volunteers, at 100 Watt the volunteers with the largest hearts had the highest cardiac output. This is interpreted as evidence for increased cardio-circulatory reserves. The contractility parameters at the various exercise grades varied dependant on heart size; when related to heart rate the variations were practically abolished. The results suggest that variations in the dynamics of small and large hearts are not primarily due to intrinsic factors but rather related to extrinsic factors such as sympathetic drive expressed by the changes in heart rate.

Adolescent↗