Biomedical subjects

G Shippey

Publications and source records attributed to G Shippey.

4 recordsLinked to original sources

PubMed1986

Operation and performance of an automatic metaphase finder based on the MRC fast interval processor.

The Medical Research Council's fast interval processor (FIP) has been adapted for metaphase finding and selection. This article summarizes recent improvements to the hardware, and describes the selection of image features. The system uses a highly simplified but effective clustering procedure to reduce computation time, and incorporates a ranking algorithm based on computed cluster features so that high-quality metaphases can be preferentially selected. Experimental results indicate that the system can detect high-quality metaphases rapidly in "rich" material and a high proportion of the available metaphases in "sparse" material. It can handle a wide range of material with good repeatability of performance.

Automation↗

PubMed1984

The use of cationic polyelectrolytes in the preparation of cell monolayers for automated cell scanning and diagnostic cytopathology.

The introduction of cationic polyelectrolytes as cellular adherents has significantly advanced the preparation of cervical scrape specimens for automated cell scanning and has also provided an efficient technique for the preparation of cell monolayers of other cytologic specimens, e.g., breast cyst fluids, urines and serous effusions, for diagnostic cytopathology. Variable thickness of cell preparation and cell overlap have both been resolved by laying cells onto glass slides coated with the cationic polyelectrolyte poly-L-lysine. We have determined the optimal conditions for pH, molecular weight, concentration and temperature for the application of poly-L-lysine as a cell-to-slide adhesive.

Cell Adhesion↗

PubMed1983

Basic performance tests on the CERVIFIP linear array prescreener.

CERVIFIP is a computer image-analysis prescreener for cervical cytology specimens. It is based on the Fast Interval Processor (FIP), a high-speed image analyzer, which uses a linear, charge-coupled, photodiode array scanner and a hardwired image data preprocessor unit for image data reduction prior to input to a computer. The software for CERVIFIP carries out real-time measurements and hierarchic classification of cells based on nuclear DNA content, morphologic and densitometric features for artifact rejection and operator review of cells suspected of being atypical. Preliminary tests have shown that the system is capable of accurate measurement of integrated optical density and positional information on cells at rates in excess of 30,000 cells per minute.

Cell Nucleus↗

PubMed1981

A fast interval processor (FIP) for cervical prescreening.

A cervical prescreening device (FIP: fast interval processor) designed to scan and classify a slide-mounted specimen within two minutes is described. The image analysis techniques are based directly on the MRC Cerviscan equipment with the minimal conversion needed to adapt these techniques for interval processing. A high scanning rate is achieved by scanning with a charge-coupled diode linear image sensor along one axis and by stepping the microscope stage continuously along the other axis. High processing rates are achieved using an asynchronous pipeline approach. Operations on pixels are carried out by parallel dedicated hardware units, while operations on intervals (segments) are carrie out using a dual microprocessing configuration. A determined attempt has been made to minimize the cost of the components required. Preliminary results showing scanning and processing performance are given.

Cervix Uteri↗