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Biomedical subjects

G Shepherd

Publications and source records attributed to G Shepherd.

47 records · Page 3Linked to original sources
PubMedDate not supplied

System failure? The problems of reductions in long-stay beds in the UK.

OBJECTIVE: To review the relevant literature on the effects of reductions in long stay beds on mental health services in the UK. METHOD: A selective literature review, with particular reference to research conducted by the author and colleagues at The Sainsbury Centre for Mental Health. RESULTS: The evidence suggests that the effects of long stay bed reductions should be examined with regard to 'old' and new long stay patients separately. While the 'old' long stay who have been most directly effected by these changes have generally fared well; the 'new' long stay have not. They are currently accumulating in acute inpatient units, often on general hospital sites, or are rotating in the 'revolving door' of acute inpatient care and inadequate community supports. Although it is clear that there is a shortage of acute beds especially in inner city areas many of the these beds are currently occupied by patients who would be better (and less expensively) cared for in community alternatives if these were available. The evidence suggests that it is possible to improve outcomes for this 'new' long stay group if specific kinds of housing, work and assertive community teams are provided. CONCLUSIONS: It is concluded that the effects of long stay bed reductions should be considered in a 'systems perspective. Effective community services can be established, but in order to achieve effective substitution of one kind of service for another, there must be a well co-ordinated, clearly targeted, and technically efficient system. At the present time such services are rare. However, simply focusing on one element (e.g. beds) is unlikely to produce cost effective and efficient solutions.

Community Mental Health Services↗
PubMedDate not supplied

Organization of heterogeneous scientific data using the EAV/CR representation.

Entity-attribute-value (EAV) representation is a means of organizing highly heterogeneous data using a relatively simple physical database schema. EAV representation is widely used in the medical domain, most notably in the storage of data related to clinical patient records. Its potential strengths suggest its use in other biomedical areas, in particular research databases whose schemas are complex as well as constantly changing to reflect evolving knowledge in rapidly advancing scientific domains. When deployed for such purposes, the basic EAV representation needs to be augmented significantly to handle the modeling of complex objects (classes) as well as to manage interobject relationships. The authors refer to their modification of the basic EAV paradigm as EAV/CR (EAV with classes and relationships). They describe EAV/CR representation with examples from two biomedical databases that use it.

Database Management Systems↗
PubMedDate not supplied

Integration of multidisciplinary sensory data: a pilot model of the human brain project approach.

The paper provides an overview of neuroinformatics research at Yale University being performed as part of the national Human Brain Project. This research is exploring the integration of multidisciplinary sensory data, using the olfactory system as a model domain. The neuroinformatics activities fall into three main areas: 1) building databases and related tools that support experimental olfactory research at Yale and can also serve as resources for the field as a whole, 2) using computer models (molecular models and neuronal models) to help understand data being collected experimentally and to help guide further laboratory experiments, 3) performing basic neuroinformatics research to develop new informatics technologies, including a flexible data model (EAV/CR, entity-attribute-value with classes and relationships) designed to facilitate the integration of diverse heterogeneous data within a single unifying framework.

Amino Acid Sequence↗
PubMedDate not supplied

Donepezil overdose: a tenfold dosing error.

OBJECTIVE: To report toxicity resulting from donepezil administration following a tenfold dosing error. CASE SUMMARY: A 79-year-old white nursing home patient with a history of Alzheimer disease and hypertension was inadvertently given 50 mg of donepezil instead of her usual 5-mg dose. She presented to the emergency department with nausea, vomiting, and persistent bradycardia (HR in the 40s). Routine laboratory studies were all within normal limits. Basilar rales were noted five hours after arrival. She was treated with atropine 0.2 mg as needed for bradycardia (HR <50 beats/min); a total of 3.0 mg was administered over 18 hours. Each bolus kept her HR >60 beats/min for one-half to two hours. No further vomiting or evidence of pulmonary edema occurred after her initial episodes. She returned to baseline by day 2 (HR in the 70s) and was returned to the nursing home. DISCUSSION: Donepezil is a centrally acting, reversible cholinesterase inhibitor that is used in the treatment of Alzheimer disease. Donepezil is highly specific for neural acetylcholinesterases, preferentially binding acetylcholinesterase by greater than three orders of magnitude over butyrylcholinesterases. This specificity minimizes peripheral adverse effects at therapeutic doses. Our patient mainly experienced bradycardia and had minimal secretory effects compared with what is usually seen with nonspecific cholinesterase inhibition. Medication errors like the one that produced this overdose are a common but preventable cause of morbidity in healthcare facilities. CONCLUSIONS: A tenfold dosing error caused donepezil toxicity. The main effect of this overdose was bradycardia, which responded to atropine therapy.

Aged↗
PubMedDate not supplied

Manic depression: do people receive adequate support?

The paper describes a national survey of the membership of the Manic Depression Fellowship. The demographic characteristics of those with manic depression indicated that they were similar to that of community surveys of people with the disorder. Of the respondents, 89% reported at least one hospital admission. The results highlight the need for awareness of manic depression among ward nurses and the importance of community mental health nurses in the assessment and monitoring of suicide risk, the provision of information and help with vocational rehabilitation.

Bipolar Disorder↗