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G Serio

Publications and source records attributed to G Serio.

At least 109 records · Page 6Linked to original sources
PubMed1989

Is adipose tissue a normal component of the myocardium?

We performed a histological comparative study between endomyocardial biopsies taken from 138 patients with various cardiac pathologies and from 42 autoptic hearts (all negative for right ventricular dysplasia), measuring the amount of adipose tissue in isolation or associated with fibrous tissue. In the clinical cases these features were present in 24 instances on the right and in one on the left side of the ventricular septum, to an extent of more than 20% of the section in six patients, clinically positive for right ventricular dysplasia. On autoptic biopsy, fibro-adipose tissue was found in seven hearts, with different distribution on both ventricles, but to a maximum amount of 20% of the section. The right side of the ventricular septum was affected in five instances. Therefore in our material there is a quantitative difference on right ventricular biopsy with respect to fibro-adipose tissue in normal hearts and in cases with right ventricular dysplasia.

Adipose Tissue↗
PubMed1989

Thoracic complications of pancreatitis.

Pancreatitis may be associated with thoracic complications, notably chronic massive pleural effusion (CMPE) and, rarely, pseudocysts with mediastinal extension (PME) and enzymatic mediastinitis (EM). Our personal experience with 14 cases of thoracic complications (nine CMPE, two PME associated with pleural effusion, and three EM of 670 patients who underwent surgery; of these, 191 had acute and 479 had chronic pancreatitis) during 16 years (1970-1986) is reported. In the patients with CMPE, the initial symptoms were progressive dyspnea eventually associated with cough and chest pain. In the PME cases, there was dysphagia associated with left subscapular pain and left chest pain. The initial signs in the patients with EM were sudden dyspnea, cyanosis, retrosternal pain, tachycardia, and acute heart failure. A fistula between the pancreatic ductal system and the pleural cavity in seven of the nine patients with CMPE was demonstrated by intraoperative pancreatography and/or cystography. On the contrary, preoperative endoscopic pancreatography demonstrated the sinus tract in only three of the seven. In both cases of PME, computed tomography (CT) provided a correct diagnosis that was confirmed at surgery. In the patients with EM, the diagnosis was suggested by the clinical appearance and was confirmed by the chest roentgenogram and by CT. All patients had operations after varying periods of unsuccessful 2-4-week-long conservative treatment. One patient with infected ascites died postoperatively. There were no thoracic recurrences of pancreatic disease among the other patients at a 10-month-10-year follow-up observation after surgery.

Acute Disease↗
PubMed1989

Isolation of keratinophilic fungi from the dust of ferry boats and trains in Italy.

The occurrence of fungi of the genera Epidermophyton, Microsporum, Trichophyton and Chrysosporium in dust collected from 10 ferry boats and 11 railway cars in Italy was studied. Ferry boats: 101 colonies of fungi were isolated. Of the dermatophytes, E. floccosum represented 2.0% of all the colonies isolated, M. canis 3.0%, M. gypseum 5.0% and Tr. mentagrophytes represented 2.0%. E. floccosum was isolated from 2 ferry boats, M. canis from 3, M. gypseum from 4 and Tr. mentagrophytes from 2. Only two ferry boats appeared to be free of pathogenic fungi. Of all the species isolated, Chr. pannorum was the most numerous (45.4%). In all five species of Chrysosporium were isolated. Railway cars: The final destination of the trains, coming from various cities, was Rome's Termini Station. 336 strains were isolated. The following species were found: E. floccosum 3%, Tr. mentagrophytes 4.8%, Tr. tonsurans 0.3%, Tr. ajelloi 0.6%, Trichophyton spp. 3%, M. canis 5% and M. gypseum 1.5%. Seven different species of Chrysosporium were isolated. Chr. pannorum was the most numerous one (71% of all). Regarding the occurrence of dermatophytes, E. floccosum was isolated from 8 of the 11 trains examined, M. canis from 10, M. gypseum from 4, Tr. mentagrophytes from 8 and Tr. tonsurans from only 1 of the trains. All of the trains were positive for pathogenic fungi, ranging from a minimum of 2 species to a maximum of 4.

Animals↗
PubMed1986

[Retroperitoneal neurilemmoma (considerations on 4 cases)].

The authors show 4 cases of retroperitoneal neurilemmoma, surgically treated by simple excision of the tumour. From the general observations, as well as from the analysis of the literature, they can remark the rareness of the location in such anatomical region. The clinical symptoms are common to those of the region retroperitoneal tumours, and are due to the compressive effect developed by the tumour on the contiguous structures. As regards the diagnostic procedures, they emphasize the primary value of axial computed tomography in the evaluation of the retroperitoneal pathology. The diagnosis cannot be but histologic, and is based upon the presence of the typical histologic pictures according to Antoni A and B types.

Adult↗
PubMed1986

[Hemodynamic status in liver cirrhosis with portal hypertension: a retrospective study on 49 patients].

The Authors report on the data obtained and their evaluation by means of analysis of seven variables and four indices, in 49 cirrhotic patients with portal hypertension and in 10 control patients. Haemodynamic analysis offers the possibility of identifying the dynamic transition stages of a response to stress showing varying degrees of compensation and establishing categories of patients on the basis of cardiovascular and metabolic parameters in relation to liver damage. The Authors, according to Siegel studies, retain that this is a valid method which enables us to obtain useful information on the haemodynamic status of the cirrhotic patient with portal hypertension.

Angiography↗
PubMed1984

The identification of the periodic behaviour in an epidemic model.

In this paper we study a method for the identification of the unknown parameter of the periodic function and also the first component of the state vector, in a mathematical model which describes the evolution of some diseases with an oro-fecal transmission. To solve the identification problem we use a numerical method to integrate the differential equations system, which reproduces the stability properties of the above mentioned continuous system. The numerical methods which we propose can be applied also to a spatial semi discretization of the reaction-diffusion model which is a diffusive generalization of the system that we consider in this paper. Finally, through an analysis on both the continuous and the discrete system we also obtain a necessary condition on the experimental data in order that a periodic trajectory of the system exists.

Communicable Diseases↗
PubMed1984

A new method for calculating evolutionary substitution rates.

In this paper we present a new method for analysing molecular evolution in homologous genes based on a general stationary Markov process. The elaborate statistical analysis necessary to apply the method effectively has been performed using Monte Carlo techniques. We have applied our method to the silent third position of the codon of the five mitochondrial genes coding for identified proteins of four mammalian species (rat, mouse, cow and man). We found that the method applies satisfactorily to the three former species, while the last appears to be outside the scope of the present approach. The method allows one to calculate the evolutionarily effective silent substitution rate (vs) for mitochondrial genes, which in the species mentioned above is 1.4 X 10(-8) nucleotide substitutions per site per year. We have also determined the divergence time ratios between the couples mouse-cow/rat-mouse and rat-cow/rat-mouse. In both cases this value is approximately 1.4.

Animals↗
PubMed1984

[Benign epithelial neoplasms of Vater's ampulla. Usefulness of the "epithelial dysplasia" concept in prognosis and surgical strategy].

The surgical behaviour in front of the benign epithelial tumors (adenomas) of Vater's ampulla is object of discrepancies due to the possible malignant evolution of such neoplasms. The authors stress the basic importance of a careful examination of histological bioptic material before and/or during operation, which, through the identification of the degree of epithelial dysplasia, may lead to the choice of the tecnique to be adopted. In 2 of the 3 cases reported by the authors, showing a low degree dysplasia of the papillary tumor, a submucous papillectomy was performed; in the third case, where histology showed severe dysplasia and some other elements of risk were present (patient's age and macroscopic features of the tumors), the surgeons performed a duodenopancreatectomy. Semiseriated histological sections of the surgical specimen revealed the presence of carcinomatous areas. The authors think simple papillectomy to be the surgical procedure to follow when low grade dysplasia of ampulla is documented, and duodenopancreatectomy to be performed in high risk conditions as high grade dysplasia and macroscopic features suggestive of malignancy. In addition, the authors deal with epidemiology, clinics and instrumental diagnostics of such benign neoplasms of ampulla, on the basis of their own experience and the review of the few cases reported in literature.

Adenoma↗
PubMed1983

[Retroperitoneal tumors. Tactics, technics and surgical results].

Out of 33 cases of retroperitoneal tumours (TRP), collected throughout 11 years (1970-1981), 8 (24%) resulted benign, 25 (76%) malignant. Liposarcoma resulted the most frequent tumour. In 11 of the 25 cases of malignant TRP (44%), a radical removal of the tumour was performed; in 8 (32%), a palliative demolition, and in the remaining 6 (24%) a simple diagnostic laparotomy. In 10 of the 19 demolitive operations (53%) the removal was extended to contiguous organs: kidney, adrenal glands, colon, pancreas, spleen, bladder, stomach. The postoperative mortality was 6%. The cases of recurrence after operations considered radical were 5 (45%). Out of the 8 patients suffering from benign neoformations, 7 underwent simple removal, and result recovered. The global survival for malignant TRP was 20% after 5 years and 8% after 10 years; as related to the cases subjected to radical removal, it results 45% and 18% respectively. The Authors maintain the essential function of computerized axial tomography (TAC) in the preoperative anatomo-topographic outlining of the retroperitoneal mass and in the early recognition of the remote recurrences. An aggressive surgical behaviour seems to be presently the primary therapeutical solution; nevertheless, the encouraging results obtained through the complementary treatment (radiotherapy and chemotherapy) command the necessity of a pluridisciplinary management of the treatment of TRP as an essential condition for the improvement of the remote results.

Adult↗
PubMed1983

[Primary malignant neoplasia of the exocrine pancreas: epidemiological findings, risk factors, early diagnosis. Personal case reports, 1970-1981].

The Authors report their own casuistry of malignant tumours of exocrine pancreas, collected in the period from 1970 up to 1981. The question was of 214 cases, namely 136 of head and 78 of body-tail or diffused. The male/female ratio was 2.3:1, the most affected decades were 6th and 7th, with a range of 27-86 years. The resecability was 27% for tumours of head and 24% for those of tail; the operative mortality was 10.8% and 17.6% respectively; the survival after 3 years was 6.8% (head) and 5.8% (body-tail), after 5 years 6% (head) and zero (body-tail). In analysing the etiopathogenetic rôle of some factors and some pathological associations, the Authors particularly point out the predisposing rôle of both tobacco smoke and diabetes, remarked in 50% and 33% of the cases observed, respectively. From a symptomatologic standpoint, the symptoms are subdivided into initial symptoms (retrospectively interpreted as first manifestation of the disease), symptoms of alarma (leading to the attending physician's), symptoms at the entrance (hospitalization), and importance is given to the exploitation of the initial symptoms for the purpose to reach a diagnosis as precocious as possible, since 40% of the tumours of head are hospitalized only after 8-16 weeks and 33% of the tumours of body-tail after 16-32 weeks from the arising of the first symptom.

Adult↗
PubMed1983

[Cystic neoformations of the retroperitoneal space (4 case reports)].

Based on the study of four cases of retroperitoneal cysts, the complex histopathogenesis of these neoplasms - the clinical diagnosis of which has recorded substantial progress thanks to the use of the computed tomography - has been analyzed. The practice of exeresis, though comparatively simple and radical in most cases (as recorded in 3 out of the 4 cases reported) owing to the little adhesions of these neoplasms to the contiguous anatomical formations and also to their histological benignity, may, in some instances, present such unexpected difficulties due to the expansion in volume and the complex and delicate anatomical connections, that palliative operations have to be opted for.

Adult↗
PubMed1982

[Vascular problems in destructive pancreatic surgery].

Obstacles of vascular type may hinder or prevent pancreatic destruction for tumours of the pancreas or periampullary tumours. Out of 72 major pancreatic demolitions (cephalic duodenopancreatectomy or subtotal pancreatectomy from rt to lt) there were vascular difficulties on 26 occasions (36%), of which 15 were in existence prior to development of the neoplasia (anomalies of rise and course of peripancreatic vessels, stenosis/obliteration of the common hepatic artery in pancreatic head or periampullary tumours) and 11 due to tumoral growth (direct involvement of the mesenteric-portal tract, the hepatic artery and the superior mesenteric artery). The technical solutions used are discussed individually in the light of the physiopathological repercussions consequent on any temporary or permanent interruption of important hepatic and splanchnic vascularisation vessels (hepatic artery and various mesenteric a.), in relation to operating mortality and the prospects of long-term survival. In the most complex cases of direct vascular involvement by the neoplasia, the Author's trend was orientated to a position which, while accepting demolition decisions useful for the widening of the surgical radicality margins, nevertheless avoids extensive demolition solutions imposed by conditions of necessity or considerations of principle that probably do not bring significant advantages as regards long-term prognosis for these tumours.

Aged↗
PubMed1982

[Vascular problems in pancreatic demolitory surgery].

Obstacles of vascular type may hinder or prevent pancreatic destruction for tumours of the pancreas or periampullary tumours. Out of 72 major pancreatic demolitions (cephalic duodenopancreatectomy or subtotal pancreatectomy from rt to lt) there were vascular difficulties on 26 occasions (36%), of which 15 were in existence prior to development of the neoplasia (anomalies of rise and course of peripancreatic vessels, stenosis/obliteration of the common hepatic artery in pancreatic head or periampullary tumours) and 11 due to tumoral growth (direct involvement of the mesenteric-portal tract, the hepatic artery and the superior mesenteric artery). The technical solutions used are discussed individually in the light of the physiopathological repercussions consequent on any temporary or permanent interruption of important hepatic and splanchnic vascularisation vessels (hepatic artery and various mesenteric a.), in relation to operating mortality and the prospects of long-term survival. In the most complex cases of direct vascular involvement by the neoplasia, the Author's trend was orientated to a position which, while accepting demolition decisions useful for the widening of the surgical radicality margins, nevertheless avoids extensive demolition solutions imposed by conditions of necessity or considerations of principle that probably do not bring significant advantages as regards long-term prognosis for these tumours.

Aged↗
PubMed1981

[Insular tumours of the pancreas (author's transl)].

The use of immunohistochemistry and radioimmunological assay of the pancreatic polypeptides in the plasma has contributed substantial advances to the histophysiopathology and preoperative diagnosis of tumours of the endocrine pancreas and the related functional syndromes. Consequently, in addition to furthering knowledge on clinical pictures already known for some time, it has been possible to define new categories of the disease which were previously misunderstood or confused with others. The physiopathology and diagnostic methodology (clinical, biohumoral and instrumental) of each main known syndrome (insulinoma, Zollinger-Ellison Syndrome, Verner-Morrison disease and glucagonoma) are described in detail; there are notes on hormonal syndromes that are not fully known and which constitute a field of research in evolution (pluriendocrine and carcinoid syndromes, polypeptidoma, somatostatinoma, nesidioblastosis). The problems of preoperative preparation, intraoperative diagnostic tactics and surgical technique are illustrated. Lastly the possibilities of alternative therapeutic treatment are outlined.

Acute Kidney Injury↗
PubMed1980

[Cavitary lesions and carcinoma of the pancreas. Diagnostic difficulties and errors].

Among 197 pancreatic and periampullar tumours operated between 1970 and 1979, an associated cystic of pseudocystic lesion was found on 15 occasions (a rate of 16%). In 10 cases it was a question of pseudocysts located at the bodytail, while the tumour occupied a distinct site (periampullar tumour or carcinoma of the head); in 5 cases the cavitary lesion coincided with the tumour (2 endocrine tumours of the head, 2 cystoadenocarcinomas and one adenocarcinoma of the body-tail). In 6 cases (of which 5 operated) the error in diagnosis led to misappreciation of the tumour: only 3 of these cases could be treated with radical surgery. In the other 9, correct diagnosis was possible from the start and in 6 radical surgery was performed. Stress is placed on the need for prompt and early diagnosis, in order to allow adequate treatment of the tumour in line with the canons of radical action.

Adenocarcinoma↗