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Biomedical subjects

G Serio

Publications and source records attributed to G Serio.

At least 199 records · Page 11Linked to original sources
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[The discharge form: advantages and limits legionellosis cases individuation].

Despite legionellosis surveillance is active in Italy since many years, the disease notification appears still undervalued. A multicentric survey was carried out among 5 big Italian hospitals. It examined 11,435 discharge forms (1999-2001), reporting pneumonia diagnosis. Legionellosis (II class of notify system for infectious disease) was studied among pneumonia diagnosis by discharge forms. According to the ICD9-CM, there's no specific code for legionellosis (this disease is included among "others gram-negative pneumonia"). So the presumed pneumonia imputable to Legionella spp were the 2.7% of the whole number of analyzed discharge forms. Besides, the data regarding the other pneumonia showed that the etiological agent was specified only in the 11.2% of the case. This situation could be rectified both introducing adequate discharge forms codes and promoting the etiological diagnosis during the hospital stay.

Adolescent↗
PubMedDate not supplied

Drinking habits and performance in an attention test in young people frequenting discotheques.

Throughout July and August 2002, at the same time as a campaign on driving safety, questionnaire and breath alcohol tests was submitted to young people outside the best-frequented discotheques of the Apulia area (Italy), to describe the role of alcohol intake in the evening-time amusement and assess its influence on their attention level. 217 young people, aged between 18-30 years, accepted to fill in a questionnaire, and undergo a 'breathalizer' test and attention test, before and after having spent time in the discotheque. The score difference between entry and exit on the attention test was -1.48 points and alcohol blood level increase up to 0.14 g/l. Established the lower reference limit for the attention test to be 21 points, it was found that 9.7% had an attention score lower than the reference limit, and 61.9% of this group had a blood alcohol level higher than 0.5 g/l. A linear regression model between the difference of blood alcohol level before and after the time spent in the discotheque and attention score on exiting from it, turned out to be statistically significant. It's necessary to go on with continuous police checks and informative awareness campaigns regarding alcohol use, driving and night amusement.

Adolescent↗
PubMedDate not supplied

c-erbB-2 gene product-like expression in urothelial carcinomas of the human bladder. Its value as a prognostic indicator in superficial tumors.

54 transitional cell carcinomas and 8 mucosal biopsies of the human bladder were stained with monoclonal 3B5 antibody, using three stage peroxidase technique. The antibody is raised against intracytoplasmic domain of the human c-erbB-2 gene product. 37 (69%) carcinomas and 1 specimen with hyperplastic-dysplastic changes, showed positive staining. There was good correlation between c-erbB-2 protein expression and extent of tumor invasion. Correlation with clinical course showed that it was also a good predictor of superficial tumors.

Aged↗
PubMedDate not supplied

Immunohistochemical demonstration of papillomavirus structural antigen in urinary bladder papillary tumors.

Clear cells with characteristic features of koilocytotic atypia (perinuclear clear zone, peripheral cytoplasmic condensation and hyperchromatic nuclei), were found in 35 out of 744 urothelial papillary tumors (UPT) of the human bladder. Using a peroxidase-antiperoxidase staining technique, papillomavirus common structural antigen was detected in six of the samples studied. The results suggests that urinary bladder tumors like some other genital cancer, may be linked to papillomavirus infection.

Adult↗
PubMedDate not supplied

Sacrococcygeal chordoma: a case report. Fine needle aspiration cytologic and histopathologic findings.

A case of sacrococcygeal chordoma diagnosed by FNA in a man 66-year-old male is presented. Subsequent histologic examination confirmed the diagnosis. The cytologic criteria for differentiating chordoma from chondrosarcoma, mucinous metastatic adenocarcinoma and myxopapillary ependymoma are review. The main diagnostic findings of chordoma include the vacuolated cells and the presence of bland nuclear features.

Adenocarcinoma↗
PubMedDate not supplied

[Mathematical models in epidemiological studies. I. Application to the epidemic of cholera verified in Bari in 1973].

An analysis of the cholera epidemic which occurred in Bari in 1973, is carried out under the assumption that the main infection source has been the widespread consumption of "raw fish". The analysis is based on a chain-binomial model which appears to be suitable to describe the epidemic. A statistical evaluation of the parameters of the model confirms the initial hypothesis, owing to the observed rapid decreasing of the probability of infection, which occurs immediately after the disinfection of the sewage going into the sea.

Adolescent↗
PubMedDate not supplied

[Mathematical models in epidemiological analysis. II. Typhoid fever: time series analysis (author's transl)].

In this paper the systematic analysis of oro-faecal infectious diseases is continued. In order to propose a dynamic model for the evolution of the endemic typhoid fever, we have studied the behaviour of the number of cases of this disease in the town of Bari (Italy) during the years 1955-1978, by the methods of time series analysis. The analysis has pointed out the typical seasonal character of such a disease, and in particular the presence of a main winter cycle followed by a less evident summer cycle. The stochastic model which has been identified on the basis of the data from 1964 to 1978 allows a forecast for the years after 1978.

Epidemiologic Methods↗
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Nuclear morphology and histological grading of oral squamous cell carcinoma (OSCC). A morphometric study.

Histological grading of oral squamous cell carcinoma (OSCC) is usually evaluated in a semiquantitative way and this causes a low grade of reproducibility of this prognostic evaluation. The aim in this preliminary phase is to investigate the relation between nuclear shape (studied by an analytical procedure) and histological grading to evaluate the weight of nuclear shape and dimension in grading formulation. Nine cases of OSCC were studied (3 cases of G1, G2 and G3 respectively) with 20 nuclei for each case. All the tumors were localized on the lip. Histologic grading according to the Bryne system was performed. Each nucleus was submitted to a morphometrical study by the SAM (Shape Analytical Morphometry) system which, apart from dimensions allows us to evaluate nuclear contour irregularities and nuclear shape asymmetry. Nuclei of squamous cell carcinoma show a progressive increase in dimensions (area, perimeter and diameter) from G1 to G3. Nuclei of G3 carcinoma are characterized by the most irregular shape. Size differences (mean value) are significant to differentiate G1 nuclei from G2 and G3 nuclei while shape parameters are useful in distinguishing G3 nuclei from G1 and G2. Multivariate discriminant analysis showed that by using only nuclear parameters it is possible to correctly classify about 80% of nuclei. This study, using quantitative methods, confirmed nuclear pleomorphism to be the most important feature in grading evaluation.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[Treatment of pain in advanced-stage intra-abdominal neoplasms].

Different types of pain are present in far advanced intra-abdominal cancer, sometimes in the same site too. An accurate semeiological analysis of pain is important because different types of pain often differently respond to the available therapeutical tools. In this paper the results and the complications of the most important methods of pain management in far advanced intra-abdominal cancer are examined. Analysis of the data reveals that the association of more methods, pharmacological and non, should be a rule rather than the exception.

Abdominal Neoplasms↗
PubMedDate not supplied

Nuclear shape and axillary metastases in breast cancer. Analytic morphometry of aspiration smears.

The aim of this work was to seek quantitative parameters other than dimensions to describe nuclear shape and, by this means, to determine the sum of contour irregularities and large asymmetries and seek a connection with the biologic behavior of the tumor. Nuclei of the cells obtained from 57 aspiration smears of breast cancers were studied. Dimensional parameters (area, perimeter, maximum diameter and roundness factor) and analytic parameters were computed by the Shape Analytical Morphometry software system to evaluate both contour irregularities and asymmetry of nuclear shape. All the tumors were subdivided according to their diameters into two groups: T1 tumors, the maximum diameter of which was < 2 cm (18 cases), and T2 tumors, the maximum diameter of which was > 2 cm and < 5 cm (39 cases). Among T1 tumors, both dimensional and analytic parameters were highly significant (P < .001) in distinguishing tumors with (N+) and tumors without (N-) axillary metastases, while among larger tumors (T2) only the analytic parameters showed degrees of significance, albeit variable. It could be inferred that in smaller tumors, aggressiveness is related to an increase in nuclear dimensions and shape distortions more so than in larger tumors.

Biopsy, Needle↗
PubMedDate not supplied

Recurring intracranial meningiomas. Morphometrical evaluation of nuclear pleomorphism by S.A.M. (shape analytical morphometry) system.

Meningiomas are the most common neoplasms of the central nervous system and their biological behavior is not always predictable from the histologic appearance of the tumors. The nuclear pleomorphism seems to be one of the most important morphological features in the prediction of recurrence. By using analytical morphometric methods it is possible to quantify nuclear atypias and to obtain parameters describing nuclear contour irregularities and distortions of the figure. Moreover the amount of information obtained from analytical procedure allowed to discriminate, by multivariate discriminant analysis recurrent or no-recurrent meningiomas (5% of error).

Cell Nucleus↗