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Biomedical subjects

G Seidl

Publications and source records attributed to G Seidl.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Realtime sonography in the diagnosis and follow-up of malignant tongue tumors. II. Detection and staging].

92 sonographic examinations performed in 62 patients were evaluated to determine the possible application of sonography in the diagnosis and follow-up of malignant tumours of the tongue. Squamous cell carcinomas were by far dominant and proved to be hypoechoic, mainly inhomogeneous and ill-defined masses. In most cases, they ranged between 2 and 4 cm. in diameter. In 50% of the lesions an infiltration of the pharynx wall was confirmed, and exulcerations were correctly detected by sonography in 75%. In preoperative determination of the size of the tumour, sonography correctly detected the size in 93% of the cases and was thus markedly superior to the clinical palpatory examination, which determined a mere 43% correctly. Sonography should be included in the pretherapeutic staging of tumours of the tongue to objectify the clinical findings. It is also adequate to document tumour behaviour during radiation.

Aged↗
PubMed1986

[Comparison of the renal ultrasound-furosemide test with the isotope nephrogram. Possible clue to the retention phenomenon?].

In 23 patients with essential hypertension renographic and sonographic examination of the kidneys was compared. No correlation could be observed for functional parameters and urinary excretion between the two different methods. Correlations have only been detected between renographic retentions and furosemide-conditioned swelling of the kidneys in sonography: patients with severe retention showed a statistically significant stronger response to furosemide. The increased retention in the renal pelvis could be responsible for alterations in sonographic findings. This study provides new data on the mechanisms of retention, whereby retention in the renal pelvis in some patients seems to be most probably caused by nephrosclerosis.

Adult↗
PubMed1986

Sonography of the tongue and floor of mouth. Part II: Neoplasms of the tongue.

Frequently, correct evaluation of space-occupying lesions in the tongue is not possible with clinical methods only. In an attempt to assess the value of sonography in the detection of tongue lesions, we used submental sonography to examine 62 patients with suspicious palpatory findings upon physical examination of the tongue. Ultrasound detected 45 out of 47 tumours that were eventually confirmed either by surgery or by biopsy. Inadequate technique was the only factor that affected the detection rate. Sonography appears to be a reasonable guide in determining size and site of a tumour of the tongue. Thus, more precision in therapy planning may be achieved.

Aged↗
PubMed1986

[Evaluation of real-time sonography in the pretherapeutic staging of malignant tumors of the tongue and mouth floor].

Based on our three years experience with about 200 transcutaneous real-time sonographies of the tongue and the floor of mouth, an assessment of the determination of size and site of 38 pretherapeutically examined malignant tumours (35 squamous cell carcinomas) was made. The patients were examined in reclined position, the head retroflected. Curved array transducers of 5 or 7.5 MHz and a silicon elastomer block as interface turned out to be optimal. All tumours could be detected by sonography as hypoechoic, more or less homogeneous, ill-defined areas. Two thirds of the tumour ulcerations could be seen as hard hyperechoic reflexes within the hypoechoic areas. When comparing the maximal diameter of tumours of the 20 operated patients, we found an agreement (5 mm tolerance) of sonography with the surgical specimen in 14 of 20 tumours (70%), of sonography with the clinically estimated diameter in 10 of 20 tumours (50%), whereas the clinically estimated diameter was in agreement with the surgical specimen in only 8 of 20 tumours (40%). A peritumoral inflammatory infiltration can simulate a larger tumour size in sonography. The extent of tumours within the tongue, to the floor of mouth, the lateral pharyngeal wall and the preepiglottic space was documented correctly in most cases. In three cases a previously unknown spread across the midline was found sonographically. Including the sonographic findings in the TNM classification, 5 T1 tumours would have been staged as T2 and one T3 tumour as T4. Inflammatory diseases of the tongue can show the same sonomorphology as malignant tumours.

Adult↗
PubMed1985

[Ultrasound guided puncture of wall fixed intrathoracic processes].

To improve differentiation of intrathoracic lesions in the vicinity of the chest wall, 167 patients were investigated via sonography. In the case of an indication the lesions were punctured, assisted by sonography. Sonography proved helpful in differentiating between liquid and solid masses and in localising the spot for puncture resulting in the successful removal of material for cytologic analysis in all our cases without any complications. The results of the study are presented, and the sonographic morphology is shown.

Biopsy, Needle↗
PubMed1985

[The use of sonography in the diagnosis of pathological changes in the mouth floor and tongue region].

The application of real-time sonography in the area of the tongue and floor of the mouth is described. Its value is examined by a sonographic-surgical correlation of 40 examinations. In 38 cases, the sonographic findings correlated well with the clinical picture, as well as with the intraoperative and pathologic findings. Ultrasound seems to be a practicable imaging method, especially with malignant infiltration of the tongue.

Carcinoma, Squamous Cell↗
PubMed1985

[Sonographic, clinical and surgical correlations in the diagnosis and control of the course of tongue infiltrations].

With a high-resolution sonographic system, anatomical details in the area of the floor of the mouth and tongue are visualized. The value of sonography in the pretherapeutic assessment of suspicious palpation findings was investigated. 22 patients' tumors were examined during radiation, to document the course of therapy. 55 sonograms were evaluated and confirmed the excellent applicability of this procedure in the precise pretherapeutic determination of the size of the lesions and their relation to the surrounding structures. The tumors are readily detected even during radiotherapy.

Humans↗
PubMed1984

[Radiologic-endoscopic correlation in ulcerative colitis].

Double-contrast irrigoscopies (DCI) performed in 32 patients with confirmed ulcerative colitis are reviewed and correlated with colonoscopy. Whereas endoscopy proved more efficient in assessing superficial changes of the mucosa, DCI was found to be superior in the detection of deeper mucosal lesions and changes in the anatomic aspect of the colon wall. Moreover, DCI showed advantages in the evaluation of the entire colon including the coecum; examination of the coecum by endoscopy was achieved in 31% only of the scrutinised cases.

Colitis, Ulcerative↗
PubMed1984

[Fine relief of the stomach and diagnosis of gastritis. A radiologic-endoscopic-histologic comparative study].

To assess the sensitivity of radiology in diagnosis of gastritis within 2 hours endoscopy and biopsy of the stomach and double contrast barium meal were performed. The diagnosis was established of the morphologic picture of the areae gastricae, which were sufficient visible in 33 out of 50 cases (66%). In 7 patients radiologic findings were normal, 13 patients showed superficial gastritis, 10 patients had superficial gastritis with signs of atrophy and in 3 patients there was an erosive gastritis. In all 33 patients (100%) there was a complete correlation of radiologic and endoscopic findings, in 24 out of 33 cases (73%) even correlation between radiologic and histologic classification. These results are discussed and confrontated with literatures.

Adult↗
PubMed1984

Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans.

Naftifine, a new antimycotic drug of the allylamine class, is a potent inhibitor of ergosterol biosynthesis in Candida albicans. Treated cells showed a dose-dependent drop in ergosterol content; the level was reduced by 60% at concentrations of greater than 50 mg/liter, causing total inhibition of growth. This inhibition coincided with a heavy accumulation of the sterol precursor squalene. Radiolabeling experiments showed that the inhibition of sterol synthesis was complete within 10 min of exposure of cells to the compound. Control cells incorporated [14C]acetate into nonsaponifiable lipids composed primarily of ergosterol, whereas naftifine-treated cells accumulated only labeled squalene. When the drug was removed by washing cells thoroughly in 1% Tween 80, the accumulated squalene was further metabolized to ergosterol. A similar pattern of inhibition was observed in sterol biosynthesis from [14C]mevalonate in a cell-free system. At 50 mg/liter, naftifine gave greater than 99% inhibition of sterol biosynthesis both in whole cells and in cell extracts of C. albicans. The primary action of naftifine appears to be the blocking of fungal squalene epoxidation.

Acetates↗
PubMed1983

[Human calcitonin in the treatment of symptomatic Paget's disease].

We evaluated the effect of a 6 months trial with synthetic human calcitonin in 10 symptomatic patients with polyosseous Paget's disease of bone. All patients reported a distinct clinical improvement which correlated with a significant decrease of alkaline phosphatase in the plasma and hydroxyproline and calcium excretion in the urine. Though no changes in skeletal x-rays were observed, the bone lesions showed a significant decrease of activity in tho bone scintigrams. Histologically there was a marked decrease of bone turn-over calcitonin therapy. No patient revealed the formation of autoantibodies against exogenous calcitonin after treatment.

Aged↗
PubMed1983

[Tumor-like bursal calcifications due to uncontrollable hyperphosphatemia in chronic hemodialysis. Case report].

The most important factor that appears to be associated with soft-tissue calcifications in uremics is the increase of serum-phosphate levels, especially if the calcium-phosphate product exceeds the value of 75 (concentrations in mg/dl) [6]. In contrast to previous years tumoral paraarticular calcinosis is now rarely seen because much more attention has been paid to the prevention of hyperphosphatemia and because of pharmacological improvement of phosphate binding agents. Therefore, the level of serum phosphate in hemodialysed patients primarily depends on the patients adherence to the low phosphate diet and compliance with the phosphate binding therapy [4, 8]. We want to report of a patient on chronic intermittent hemodialysis who developed tremendous paraarticular soft tissue calcifications during a short period of time due to uncontrolled hyperphosphatemia despite correct intake of phosphate binding compounds.

Bursa, Synovial↗