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Biomedical subjects

G Segre

Publications and source records attributed to G Segre.

At least 73 records · Page 4Linked to original sources
PubMed1981

Kinetic analysis of the response of plasma glucose, insulin, and C-peptide to glucagon injection in normal and diabetic subjects.

A compartmental model formed by plasma glucose, proinsulin, insulin, and C-peptide was proposed to allow a quantitative evaluation of the interrelationship among the different components of the system and to obtain a better discrimination between normal and pathologic subjects. In 11 control subjects, in 6 mild diabetics, and in 9 severe diabetics (insulin-dependent), the kinetics of plasma glucose, insulin, and C-peptide after an i.v. injection of glucagon (sampling for about 120 min) were fitted to the model which was solved with digital computing techniques. Since biphasic plasma insulin and C-peptide kinetics were demonstrated in many normals and mild diabetics, the effect of glucagon in the model was represented by a differential plus a proportional effect. The model (formed by 6 compartments and 14 transfer constants) takes into account the fact that insulin and C-peptide derive monomolecularly from proinsulin and that liver inactivates insulin. The values of the parameters obtained were submitted to stepwise discriminant analysis in order to obtain their relative importance in discriminating among the three groups of subjects. With respect to normal subjects, we found in diabetics an increased inflow of glucose into plasma; a decreased effect of glucagon in promoting the proinsulin response; a decreased effect of glucose in promoting the proinsulin response; a decreased glucose utilization; a lower coupling effect of insulin on glucose; and a higher disappearance rate of C-peptide. We observed a lower formation of insulin and C-peptide from proinsulin in severe diabetics.

Adult↗
PubMed1981

Pharmacokinetics of fentiazac in rats and monkeys.

Pharmacokinetic investigations were carried out on 2-phenyl-4-p-chlorophenyl-thiazol-5-ylacetic acid (fentiazac) in the rat and in the monkey. The drug, rapidly absorbed by the gastrointestinal system, shows a long maintenance in the body, with a long half-life in both animal species. The rate of biotransformation and the times of presence in the blood circulation of both unchanged drug and of its metabolites are indicated by the serum levels of cold fentiazac and labelled fentiazac. Urinary and fecal excretion attain levels amounting to 24 and 70%, respectively, of the dose administered.

Acetates↗
PubMed1980

[Glutathione-S-transferase and glutathione in the liver and blood of rats poisoned by thioacetamide].

In rats treated with thioacetamide (250 mg/Kg i.p.) the glutathione-S-transferase activity in liver and in plasma and the glutathione content in liver have been determined at various times. The glutathione-S-transferase activity in liver supernatant decreases after 24 and 48 hours and returns to normal values after 4 days. The glutathione-S-transferase activity in liver supernatant is not inhibited by thioacetamide at 20 mM. The glutathione-S-transferase activity appears in plasma after 12 hours, with a maximum at 24 hours, followed to a decrease toward zero levels; this activity can be determined in plasma even at a dose of 10 mg/Kg of thioacetamide. The glutathione content in liver increases at 48 and 96 hours after drug administration.

Acetamides↗