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Biomedical subjects

G Schramm

Publications and source records attributed to G Schramm.

At least 73 records · Page 4Linked to original sources
PubMed1977

The strobilurins--new antifungal antibiotics from the basidiomycete Strobilurus tenacellus.

The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic form of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C16H18O3 for strobilurin A and C17H19C1O4 for strobilurin B.

Agaricales↗
PubMed1976

[Palliative surgery in upper thoracic venous obstructions].

33 patients (4.6%) of 711 surgical patients with thoracic disease had symptoms of upper thoracic venous obstructions. Histological differentiations proved the majority of tumors to be malignant. New successes in oncology-treatments of these tumors made early histological diagnosis mandatory. Our results lead to mediastinoscopies in these patients, although literature considered the risk of mediastinoscopy in upper thoracic venous obstructions as to high. We found no major complications in this group of patients and would like to emphasize the need of early histological diagnosis through mediastinoscopy in upper thoracic venous obstructions.

Adolescent↗
PubMed1975

[Cell-mediated immune-phenomenona in progressive chronic polyarthritis].

With the help of the lymphocyte transformation test 34 patients with ascertained progressive chronic polyarthritis and 20 control persons were examined. A proteoglycan fraction from normal cartilaginous tissue was used as antigen. Hereby was found: 1. The antigen-conditioned stimulation of the lymphocytes in the group with progressive chronic polyarthritis was greater than in the control persons. 2. In the formation of the transformation index the difference between the two groups could be statistically ascertained. With the help of the present examination a further proof was given that in the process of rheumatoid arthritis cellular immune phenomena play a part. However, which value cellular immune mechanisms have in the etiopathogenesis of the progressive chronic polyarthritis, cannot be answered with the results of the examinations.

Antibody Formation↗
PubMed1975

[Clinical-biochemical study of systemic panchondritis].

With the help of a casuistic and the results of own investigations clinical, differential-diagnostic, biochemical, pathogenetic and therapeutic aspects of panchondritis systemica are described. The very rare clinical picture, which coincides with chondrolysis and perichondritis, manifests itself intermittently in the region of the auricles, the nose, the cartilaginous parts of the ribs as well as of the chondroskeleton of the respiratory system and in most cases has a fatal termination. Probably on the basis of the pathogenetically decisive changes of the basic substance in addition to this arthritic symptoms, symptoms similar to Bechterew's disease, carditic as well as ocular and internal ear symptoms may appear. Results of own investigations refer to considerable abnormalities in the glucosamine glycan metabolism, in which case the question must remain open, whether these biochemical and immunologic factors are to be regarded as the primary pathogenetic cause. For avoiding irreparable and dangerous defects of the cartilage a sufficiency dosed treatment with corticoids is necessary.

Adult↗