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Biomedical subjects

G Schlager

Publications and source records attributed to G Schlager.

54 records · Page 3Linked to original sources
PubMed1966

Spontaneous mutation rates at five coat-color loci in mice.

Examination of 1.5 million mice yielded natural mutation rates estimnated from 5.2 million gene reproductions at five specific coat-color loci. The average rates were 11.1 x 10(-6) for forward mutations and 2.7 x 10(-6) for reverse mutations. Differences between the frequencies of mutations at the individual loci were evident.

Animals↗
PubMedDate not supplied

Selection for hematocrit percent in the house mouse.

Two selection experiments were designed to change hematocrit percent. In the first experiment the mice were measured at 60 days and elevated hematocritis were achieved in the first generation with no further response. In the second experiment hematocritis were taken at 100 days and two-way response continued for three generations after which the difference between the high and low lines remained constant. Realized heritability was 71-97 percent in the first generation in one experiment and 24-30 percent for three generations in the second. These compare to an estimate of the degree of genetic determination based on 21 inbred strains of 40 percent. The evidence based on the selection experiments and crosses between inbred strains indicates that few genes are involved in the genetic control of normal hematocrit levels found within inbred strains of mice. The realtionship between hematocrit level and systolic blood pressure suggested by other studies was not a consistent finding in our studies.

Animals↗
PubMedDate not supplied

Genetic study of norepinephrine in brains of mice selected for differences in blood pressure.

Norepinephrine concentration of the whole brain was found to be statistically different between the HBP and LBP mouse stains that had been selectively bred for high and low systolic blood pressure, respectively. Crosses between these strains resulted in statistically different NE levels between the reciprocal F1 males and the genetical analysis revealed a significant sex-linked factor or factors. Dissection of the brain into eight regions and subsequent biochemical analyses revealed statistically higher NE content in the LBP compared to the HBP for midbrain and cerebellum. Midbrain NE was also significantly different between the reciprocal F1's. NE concentration was then related to known behavioral characteristics in these strains.

Animals↗
PubMedDate not supplied

[Changes in cranial size and configuration in infants].

Abnormalities of cranial size and configuration include macrocephaly, microcephaly and dysmorphic skull. Hydrocephalus, mega-encephalus, abnormal growth of skull bones and chronic subdural and epidural collections are among the most important causes of macrocephaly. Primary microcephaly may be due to deficient neuronal proliferation or abnormalities in neural tube segmentation or cellular migration. Secondary microcephaly may be caused by prenatal, perinatal or early postnatal insults like infections, drugs, radiation, hypoxia, among others. Abnormal cranial forms may be sporadic or secondary to genetic and chromosomal diseases. Craniosynostosis can be managed surgically with positive results when early diagnosis and treatment are accomplished.

Cephalometry↗