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Biomedical subjects

G Schlaeder

Publications and source records attributed to G Schlaeder.

At least 19 recordsLinked to original sources

Routine prenatal care in Europe: the comparative experience of nine departments of gynaecology and obstetrics in eight different countries.

OBJECTIVE: The aim of this study was to compare routine prenatal care in nine European obstetrics and gynaecology departments. STUDY DESIGN: A survey was performed between October 1992 and November 1993 by means of a questionnaire. The questionnaire comprised 118 questions covering clinical examinations and investigations systematically performed during the pregnancy. RESULTS: The survey revealed a certain number of differences between the types of prenatal care performed by each department. Thus, one notices differences to do the serological testing (toxoplasmosis, AIDS and hepatitis B) at the first visit and in the practice of vaginal examination, systematic ultrasound examination or cardiotocography. CONCLUSION: The differences observed in the prenatal care furnished are only a reflection of our uncertainties concerning the validity of the various tests used to monitor pregnancies. At a time when financial restrictions impose choices, we consider an evaluation of the efficacy and cost of prenatal care to be essential.

Acquired Immunodeficiency Syndrome↗

[Massive feto-maternal transfusion. Report of 3 cases with review of the literature].

Massive feto maternal hemorrhage is rare. Early diagnosis is important because massive feto-maternal hemorrhage has a poor prognosis. The clinical manifestations of transplacental hemorrhage are related not only to the size of the hemorrhage but also to the time at which the hemorrhage occurs. In women who are candidates for Rh immune prophylaxis, massive feto maternal hemorrhage may be detected by Kleihauer test and we suggest that 10 micrograms dose of immune globin should be administered for each estimated ml of Rh positive blood given, to prevent an immunization Disappearance of fetal cells by Kleihauer test or appearance residual antibody suggests the adequacy of therapy. Three cases of massive fetomaternal hemorrhage (more than 225 ml) are presented here. Two mothers was Rh negative and they are delivered of rhésus positive children, which necessitated the administration of large volume of anti D. One of the cases shows the possibility of association between choriocarcinoma and positive kleihauer test.

Adult↗

Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia.

OBJECTIVE: To evaluate the activity of the renin-angiotensin-aldosterone system in the circulation during the three trimesters of normal pregnancy and in women with preeclampsia. METHODS: Normal pregnant volunteers (n = 7) were studied throughout pregnancy, and women with preeclampsia (n = 8) were studied in the third trimester. Plasma active renin and aldosterone were measured by radioimmunoassay. Angiotensin I and angiotensin II were determined by radioimmunoassay after separation of the peptides by high-performance liquid chromatography. RESULTS: Active renin concentration increased in the first trimester of normal pregnancy, whereas angiotensin I, angiotensin II, and aldosterone remained at a level comparable to the postpartum values. Highest activity of the renin-angiotensin-aldosterone system was observed during the third trimester with increased levels of angiotensin I, angiotensin II, and aldosterone. In contrast, in patients with preeclampsia, despite a slight increase of active renin levels, the other parameters of the renin-angiotensin-aldosterone system were low compared with the third trimester of normal pregnancy and were comparable to postpartum data. CONCLUSION: Our results suggest that during the first trimester of normal pregnancy, active renin concentration in the plasma is increased and that renin is not the factor that limits angiotensin II synthesis. These results also confirm decreased activity of the renin-angiotensin-aldosterone system in preeclampsia. This could contribute to the diminished hemodynamic control observed in pregnant women developing preeclampsia.

Adult↗

Etiology and prevention of pulmonary complications following beta-mimetic mediated tocolysis.

OBJECTIVES: This study documents biological (haematocrit variations) and therapeutic parameters (salbutamol doses, volumes perfused) in two groups tocolysed with salbutamol, one with and the other without APO in order to define the risk factors linked to APO and to establish a standard protocol of management. STUDY DESIGN: This retrospective study includes data from 68 intravenous salbutamol tocolysis with four resulting APOs, carried out between January 1st, 1993 and December 31st, 1995. RESULTS: There was an excessive level of salbutamol administered over 48 h in the complicated APO-group (122.5+/-52 mg) opposed to the non-APO group (44.9 21 mg) as well as an overload of perfused solute (3.1+/-1.11) versus (1.9+/-1.11). Blood hemodilution was demonstrated in the APO group with a decrease of haematocrit by over 10% between the admission and the control value. No other risk factor was found. CONCLUSION: Tocolysis should be administered at the lowest possible perfusion rate with incremental doses as long as the heart rate stays under 120 beats/min and stopped after 48 h. Administration of maximal 11 of solute perfused/day is recommended. For the patient's follow-up we estimate daily input and output fluid to avoid hydric overload, and a daily control of haematocrit whose variation must be less than 10%.

Acute Disease↗

Low-field dedicated magnetic resonance imaging: a potential tool for assisting perinatal autopsy.

Although the practice of perinatal autopsy has increased in recent years, examination of the fetus and especially of the fetal brain during the first trimester or the beginning of the second trimester remains difficult. Postmortem high-resolution images of the brain of a normal and an abnormal fetus of the same gestational age (22 weeks) were obtained with a low-field (0.1 T) dedicated magnetic resonance imaging (MRI) system. We demonstrated that a small MRI machine supplemented data from classical necropsy and may help in the interpretation of in utero ultrasound and magnetic resonance images for the antenatal diagnosis of fetal malformations.

Adult↗

Breech presentation after 34 weeks-a meta-analysis of corrected perinatal mortality/morbidity according to the method of delivery.

We conducted a meta-analysis of the mortality and morbidity of the breech presentation according to the method of delivery. Using the term 'breech', we used the Medline data base to search the English and French-language literature from 1978 to July 1995. Twenty-two studies (7239 deliveries) were found and analysed. The meta-analysis concerning perinatal mortality did not reveal a significant increased risk, when vaginal deliveries were compared with those delivered by a caesarean section (odds ratio: 1.90; confidence interval: 0.59-8.22) or when vaginal deliveries were compared with those done by planned caesarean section (odds ratio: 4.95; confidence interval: 0.44-80.06). The neonatal morbidity showed an increased risk with vaginal delivery. It is concluded that the practice of resorting to caesarean section for every breech presentation at term does not seem defensible.

Journal Article↗

[What does the cesarean rate mean in France/].

For more than twenty-five years, the cesarean rate in France, as in other developed countries, has continued to increase, and in 1995 was 15.9%. Cesareans are now taken for granted by the general public, who are usually unaware of their consequences for maternal mortality and morbidity and continue to consider this form of delivery as the safest for the new born child. Yet it has been clearly demonstrated that cesarean deliveries are associated with higher rates of maternal and perinatal morbidity than vaginal deliveries and that they increase maternal mortality by a factor of from 5 to 7. From an economic standpoint, cesareans are between two and three times more expensive than vaginal deliveries. The two main indicators which account for the increase in cesareans are cicatricial uterus and dystocia. These are indicators in which individual practitioners' normal practice and the fear of medical malpractice suits play a clear role. There appears to be a particular correlation between the proportion of cesareans and obstetricians' insurance premiums, obstetricians' own assessment of the risk of malpractice suits and the number of complaints lodged against hospitals or individual doctors. Cesareans performed on grounds of fetal suffering or breech deliveries represent a diminishing proportion of the total. The use of scalp pH and radiopelvimetry have made it possible to restrict the number of cesareans based on these indicators. Other factors play a role in this increase, such as parity, education level, type of maternity insurance, whether the hospital is private or public, whether or not there is a neonatal resuscitation unit, the size of the city and the obstetrician's experience and type of training. The time and day or delivery have also been shown to be relevant factors. For obstetricians themselves, the higher fees earned from cesareans do not appear to be important. Of more relevance is the opportunity they offer doctors to organise their schedule and save time. Among the various methods proposed for reducing the cesarean rate, a strict definition of and respect for the indications for a cesarean, involving comparisons between establishments and between practitioners, have been shown to be effective. To allow such figures to be compiled, France should therefore produce for each confinement a standard record containing the different perinatal data, as is already the case in numerous other countries.

Cesarean Section↗

Cervico-vaginal fetal fibronectin: predictive value during false labor.

OBJECTIVE: The purpose was to determine to what extent fetal fibronectin was a discriminative test of preterm delivery in patients hospitalized for uterine contractions without modification of the cervix. STUDY DESIGN: The prospective double-blind study included patients hospitalized between 24 and 34 week for false labor. Cervicovaginal swabs were obtained and assayed for the presence of fetal fibronectin by means of a monoclonal antibody assay. RESULTS: Out of the 61 patients included, 18 showed a positive swab. The correlation of a positive result with preterm delivery revealed a sensitivity of 56%, a specificity of 81%, and positive and negative predictive values of 56% and 81% respectively. Meta-analysis of studies published shows that the presence of fibronectin represents a significant relative risk of 3.3 (IC: 2.5-42) of preterm delivery. CONCLUSION: The presence of fetal fibronectin in cervicovaginal secretions of patients presenting with false labor indicates a major risk of preterm delivery.

Adult↗

[Routine prenatal care in Europe: comparison of the experience of nine gynecologic-obstetric services in eight different countries].

OBJECTIVE: The purpose of this study was to compare the routine pre-natal surveillance carried out in nine European Gyneco-Obstetric units. MATERIAL AND METHOD: A survey was carried out between October 1992 and November 1993 with the aid of a questionnaire. The questionnaire contained 118 questions covering clinical examinations and explorations undertaken systematically during the first, second and third trimesters and at the end of pregnancy before delivery. To ensure that the replies were accurate, the survey was carried out on the spot in the units concerned with the head of the unit. RESULTS: The survey revealed a certain number of differences in the surveillance carried out in the various units. The units did not all carry out systematic blood tests for toxoplasmosis, AIDS and hepatitis B at the first examination. The same applied to fasting blood glucose and the bacterial culture of the urine. Nor did all the units automatically undertake vaginal examination during the second and third trimesters and the English departments were not all convinced of the need for systematic ultrasound tests. Only five of the nine units undertook routinely cardiotocographic recordings of the fetal heart rate at the end of the pregnancy. CONCLUSION: The differences observed in the various surveillance procedures simply reflect our uncertainty regarding the different tests we use to monitor pregnancies. At a time when financial constraints are forcing us to make choices, there is an urgent need to assess the effectiveness and the cost of the various elements of our prenatal monitoring.

Cardiotocography↗

Successful cord blood stem cell transplantation for congenital erythropoietic porphyria (Gunther's disease).

Congenital erythropoietic porphyria (Gunther's disease, GD) is a rare autosomal recessive disease. It results from the deficiency of uroporphyrinogen III synthase, the fourth enzyme on the metabolic pathway of heme synthesis. GD leads to severe scarring of the face and hands as a result of photosensitivity and fragility of the skin due to uroporphyrin I and coproporphyrin I accumulation. It also causes erythrocyte fragility leading to haemolytic anaemia. The other clinical features include hirsutism, red discolouration of teeth, finger-nails and urine and stunted growth. The outcome is poor, and the disfiguring nature of GD may partly explain the legend of the werewolf. No curative treatment was known until 1991, when the first case of BMT in GD was reported. The clinical and biological outcome after transplantation was encouraging, with an important regression of the symptoms of the disease, but the child died of CMV-infection 11 months after BMT. We report the second case of GD treated successfully by stem cell transplantation using umbilical cord blood from an HLA-identical brother in a 4-year-old girl suffering from severe GD. Our patient is very well 10 months after transplantation. We confirm that stem cell transplantation is curative for GD.

Amniocentesis↗

Spontaneous regression of fetal pulmonary sequestration.

The prenatal diagnosis of pulmonary sequestration can usually be made by the third trimester of pregnancy, from the combination of an intrathoracic mass and indirect signs such as cardiac deviation, fetal hydrops, pleural effusion and polyhydramnios. We describe four cases in which pulmonary hyperechogenicity was detected before 26 weeks' gestation. In three cases the hyperechogenic mass was isolated. In all cases it had mostly regressed during the pregnancy. A review of the cases of isolated pulmonary sequestration that have been diagnosed during the antenatal period is presented. Antenatal evolution was found to be unpredictable regardless of the type or severity of the case at the first diagnosis. We propose a classification to define more clearly the optimal management of pulmonary sequestration.

Adult↗

Fetal arachnoid cyst: report of two cases.

Two new cases of antenatal diagnosis of arachnoid cyst are described. Diagnosis was made at 2.5 and 32 weeks' gestational age. In the first case, a slight increase in the diameter of the anechoic mass was observed in the second trimester. In the second case, ventricular dilatation was present prenatally. Appropriate surgical therapy was initiated at 2 months in the first case and at 8 days in the second and the neurological development of the two children is considered as normal at 18 months of age. Major features of in utero diagnosis, treatment and follow-up are discussed.

Journal Article↗

[Tocolysis using salbutamol in cases of cardiac rhythm disorders in the mother. Apropos of 4 cases].

Tocolysis was carried out in a case of paroxysmal junctional tachycardia (Bouveret) and there was an attack of paroxysmal tachycardia which resolved spontaneously. In a case of Wolff-Parkinson-White syndrome and in two cases of ventricular double extra-systoles, tocolysis was very well tolerated. A short discussion based on these four case histories is presented. The indication for the use of tocolytic drugs was discussed with the cardiologist. The cardiac state of these pregnant women under treatment was very closely monitored.

Adult↗

[Complications and psychosomatic problems after tubal sterilization].

From 1969 to 1974, 2080 patients were sterilized, 1702 by the pelviscopic method (electrocoagulation), 375 by laparotomy, and 3 vaginally. About two thirds of the sterilisations by laparotomy were carried out after delivery or during other surgical procedures. 15% of all women were sterilized for medical reasons; the other cases had to be 35 years of age or at least 30 if they had more than 3 children. The overall complication rate was 5% with both methods. Complications during pelviscopy included hemorrhage, bowel injury and burns. Postoperative complications after laparotomy were hemorrhage, thrombosis and wound dehiscence. Only half of the patients could be followed up; there were 4 pregnancies among 1308 women. In more than 50% the sexual relations had improved, in only 3% they had worsened. About 97% of the pelviscopically sterilized patients were satisfied with surgical method chosen and with their present status. It is recommended to allow sufficient time to think the decision over prior to the operation.

Adult↗