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Biomedical subjects

G Schierz

Publications and source records attributed to G Schierz.

31 records · Page 2Linked to original sources
PubMed1984

[Clinical aspects and etiology of acrodermatitis chronica atrophicans].

We followed up nine patients with acrodermatitis chronica atrophicans (ACA) for an average of 2 years (6-44 months). Extradermal symptoms were observed in five patients, three of whom developed systemic signs such as fatigue or general sensitivity to cold; three suffered from cardiac symptoms; and two had joint and/or nervous system involvement. In one patient, erythema migrans and oligoarthralgia preceded the ACA. In most patients, the laboratory tests showed changes often seen in inflammatory diseases; we found an elevation of IgA, IgG and/or IgM in five patients. Using an indirect immunofluorescence test with Ixodes dammini spirochetes as antigen, the patients had more or less elevated IgG antibody titers and insignificant IgM antibody titers; similar results were obtained in some patients when an Ixodes ricinus spirochete isolated in the area of Munich was used as antigen. We believe that ACA is a chronic spirochetosis with manifestations present in the skin, joints, nervous system, and presumably in the heart.

Acrodermatitis↗
PubMed1976

[Toxoplasma infection and toxoplasmosis. Possibilities and limitations of serological diagnosis (author's transl)].

Compared with the technically complicated Sabin-Feldman Test (SFT), the indirect immunofluorescene test (IFT), which has now been tested for the dection of toxoplasma-specific antibodies, offers considerably more favorable conditions for routine diagnosis. With the differentiation of IgM and IgG antibodies, the IFT opens up a possibility for the delimitation of acute and chronic clinically irrelevant latent stages of infection in particular, which, in comparision with the information in this regard from the SFT and complement fixation reactions is based on other immunological principles. A definitive differentiation between clincally manifest toxoplasmosis and toxoplasms infections, however, cannot be brought about serologically in this way.

Fluorescent Antibody Technique↗
PubMedDate not supplied

Reinfection in erythema migrans disease.

Two patients received oral penicillin for erythema migrans disease (EMD) in 1973 and 1977. Five and seven years later, respectively, they developed EMD for a second time after being bitten by ticks. The first and second erythema migrans lesions appeared in different places. Tests of sera evaluated for antibodies to Borrelia burgdorferi before (in one case), during and after the second episode of EMD remained negative (patient 1) or yielded an at least four-fold rise of IgG antibody titers, but did not become positive (patient 2). These cases provide evidence that reinfection in EMD may occur without a significant elevation of specific antibody titers.

Bites and Stings↗
PubMedDate not supplied

Serological diagnosis of erythema migrans disease and related disorders.

An indirect immunofluorescence technique for the determination of antibodies against ixodid tick spirochetes is described. Differences in the reactivity between Ixodes ricinus spirochete and Ixodes dammini spirochete antigens were not observed. Cross-reacting antibodies against Treponema pallidum and Treponema phagedenis can be eliminated by quantitative absorption with T. phagedenis. Cross-reactions with leptospira were not observed by immunofluorescence. In the IgM test, false negative reactions caused by high-titered specific IgG antibodies or false positive reactions caused by rheumatoid factor occur. This can be avoided by testing the IgM fraction (19S-IgM-test) or using sera previously treated with anti-IgG serum. Significantly elevated antibody titers against ixodid tick spirochetes were observed in 45% of 44 cases with erythema migrans disease, in 72% of 29 cases of lymphocytic meningoradiculitis, in all of nine patients with acrodermatitis chronica atrophicans and in all of four investigated patients with lymphocytoma (lymphadenosis benigna cutis).

Acrodermatitis↗
PubMedDate not supplied

European erythema migrans disease and related disorders.

European erythema migrans disease, lymphocytoma, and acrodermatitis chronica are a group of disorders associated with the bite of ixodid ticks. These disorders are now thought to be due to a single, or closely related, ixodid tick spirochetes. European erythema migrans disease closely resembles Lyme disease. Serological evaluation may help to separate spirochetal lymphocytoma from other pseudolymphomas of nonspirochetal origin and from lymphoma. Acrodermatitis chronica atrophicans, so far observed mainly in Europe, is presumably a late manifestation of this group of spirochetal disorders.

Acrodermatitis↗