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Biomedical subjects

G Schettler

Publications and source records attributed to G Schettler.

At least 91 records · Page 5Linked to original sources
PubMed1980

The effect of polyunsaturated phosphatidylcholine on plasma lipids and fecal sterol excretion.

Highly polyunsaturated phosphatidylcholine (PC) was orally administered to patients with familial hypercholesterolemia and normal controls. Plasma lipid and lipoprotein composition as well as fecal sterol excretion and bile lipid composition were analyzed. Two dietary regimens were given, containing similar amounts of calories, cholesterol and polyunsaturated fatty acids in order to evaluate the specific effect of phosphorylcholine. No change in plasma lipid or lipoprotein concentration was observed. However, fecal sterol excretion was substantially increased in all subjects when PC was added to the diet. Bile acids, phospholipid and cholesterol content in bile did not vary.

Adolescent↗
PubMed1979

[Acute renal failure due to diffuse cholesterol crystal embolisation during streptokinase treatment (author's transl)].

In a 65-year-old man livedo reticularis occurred in the lower half of the body two days after beginning lysis with streptokinase. This was followed by skin and toe necrosis as well as acute renal failure. Autopsy showed a severe ulcerative atherosclerosis of the aorta with cholesterol crystal embolisation in numerous organs, particularly in both kidneys. The coincidence in time leads one to assume that the streptokinase treatment encouraged acute diffuse embolisation by dissolving the protective thrombi over the ulcerative atheromatous plaques.

Acute Kidney Injury↗
PubMed1978

[Mechanism of action of synthetic heparinoids: results in patients with hypertriglyceridaemia (author's transl)].

The effect of two synthetic heparinoids, SP-54 and Depot-Thrombocid, on serum lipids was studied in 17 patients with primary hyperlipidaemia (types IIb, IV and V of Fredrickson) and 15 healthy persons. SP-54 had no lipid-lowering effect, neither on oral nor rectal suppository application. Intramuscular injection of Depot-Thrombocid, however, resulted in a decrease of serum triglyceride concentrations of maximally 50% after six hours. There was a marked increase in the activity of the two lipolytic enzymes, lipoprotein lipase and hepatic triglyceride lipase in plasma, as well as an increase in free fatty acids and an extension of thrombin time and PTT. Twenty-four hours after injection all values returned to pretreatment levels. Intramuscular administration of Depot-Thrombocid two or three times a week for seven weeks had no lasting effect on serum lipids. However, there were considerable side effects such as haemorrhagic diatheses, hair loss and thrombocytopenia.

Administration, Oral↗
PubMed1978

[Etiology and pathogenesis of arteriosclerosis].

Cardiovascular diseases are the leading cause of death in Western countries, with an enormous increase in death rate and involvement of younger age groups during the last decades. This applies especially to coronary heart disease and is mainly caused by first-degree risk factors: hypertension, hyperlipoproteinemia, cigarette smoking, gout, obesity, polycythemia, lack of physical activity, and stress. These risk factors are discussed with special reference to overnutrition and increased cholesterol levels. Recent resuults of research concerning lipids and their relation to atherosclerosis are reviewed.

Arteriosclerosis↗