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Biomedical subjects

G Sbalzarini

Publications and source records attributed to G Sbalzarini.

13 recordsLinked to original sources
PubMed1992

[Asymptomatic bilateral occipital calcifications. A possible atypical form of Sturge-Weber-Krabbe syndrome?].

Sturge-Weber-Krabbe syndrome is a rare congenital neuro-cutaneous disease which is characterized, in its full clinical expression, by facial naevus flammeus and epilepsy with mental retardation. Different atypical cases in which one or more symptoms are missing and clinical course is benign, have been reported in the literature in recent years. In the present paper a possible case of this syndrome radiologically diagnosed, without neurological and cutaneous symptoms, is reported; the importance of a more comprehensive study of this complex disorder, with particular attention to the incomplete forms, is stressed.

Adult↗
PubMed1991

[Platelet aggregation during adjuvant chemotherapy with CMF].

We have studied platelet aggregation in fourteen pre- and post-menopausal women treated with cyclic adjuvant CMF chemotherapy for mammary cancer with positive axillary nodes, previously operated. Aim of the investigation is to evaluate the effect of chemotherapy on platelet aggregation. The obtained results demonstrate that CMF therapy does not modify platelet aggregation in both pre- and post-menopausal patients.

Adenocarcinoma↗
PubMed1991

[Prognostic significance of hypereosinophilia in surgically treated breast carcinoma. Our experience].

Several Authors have published that hypereosinophilia is often related to solid carcinoma and mostly to mucin secreting epithelium carcinoma. Such hypereosinophilia has been considered a negative prognostic symptom. In this trial we have studied our out-patients affected by breast cancer who showed hypereosinophilia during their post-surgical follow-up or therapy. Such hypereosinophilia was not related to any symptom of progression of neoplasia. We thus suppose that hypereosinophilia associated with breast cancer is probably not related to the development of neoplastic tissue.

Adult↗
PubMed1991

[Carcinoembryonic antigen (CEA) and mucinous-like tumor associated antigen (MAC). Statistic correlation in advanced breast carcinoma].

In this study we have determined the plasmatic values of carcinoembryonic antigen (CEA) and mucinous like tumor associated antigen (MCA) in 20 women with metastatic breast cancer. CEA and MCA were determined by enzyme immunoassay technique. The results were analyzed by test r for the statement of statistical correlation. Since r was inferior to p 5% (r = 0.3255; p = 0.4438) the 2 parameters are not correlated and their biological expression must be considered independent.

Adult↗
PubMed1990

[Primary amyloidosis. A case report].

Primary amyloidosis is an uncommon disease which can be considered a diagnostic challenge. A recently observed case, initially characterized by peripheral neuropathy and subsequently by heart failure and sudden death, is described.

Aged↗
PubMed1989

[Chronic lymphatic leukemia with cerebral localization. A case report].

Central nervous system (C.N.S.) involvement is present in 20% of leukemic patients, while it accounts for only 2% of primary extranodal localizations of malignant lymphoma (M.L.). A clinical case in which a neurological syndrome is the opening symptom of chronic lymphatic leukemia (C.L.L.) is described.

Aged↗
PubMedDate not supplied

[Osteocalcin and hyperthyroidism].

Osteoporosis may be induced by hyperthyroidism through an increase of bone turnover, because bone resorption exceeds formation in this condition. Also therapy with 1-thyroxine, especially by TSH-suppressive doses, may induce a reduction in bone mineral content. Circulating osteocalcin (sBGP) significantly increases both in endogenous and exogenous hyperthyroxinemia and is considered a reliable non invasive marker of bone turnover. In this study an extra-increase of sBGP in hyperthyroid post-menopausal women towards pre-menopausal is reported, the persistence of high sBGP levels in patients affected by any type of hyperthyroidism after four months of therapy and a positive relationship with thyroid hormones (fT4). Therefore monitoring of this serum marker may be suggested also in patient chronically treated with 1-thyroxine to avoid, if possible, overzealous therapy.

Adult↗
PubMedDate not supplied

[Association of hyperthyroidism and diabetes mellitus. Description of a case with partial recovery of pancreatic beta-islet function].

The coexistence of Graves' disease and insulin-dependent diabetes mellitus is well known among autoimmune polyglandular syndromes and sustained by common underlying immune pathogenic factors. Hyperthyroidism itself may lead to impaired glucose tolerance in subjects with intact beta-cell function through various not well clarified mechanisms and treatment of thyroid hyperfunction, on the other side, generally ameliorates the degree of metabolic control when diabetes is pre- and/or coexisting. We report a case of Graves' disease associated with diabetes mellitus, in which a partial recovery of insulin secretion is documented after euthyroidism was restored.

Autoimmune Diseases↗
PubMedDate not supplied

[Thyrotoxic periodic paralysis and Graves' disease. Description of an HLA-CW7-positive case].

Thyrotoxic periodic paralysis is an uncommon complication of hyperthyroidism, more frequent in Oriental populations and in male than in female subjects. Electron microscopic investigations have shown characteristic degenerative changes of muscle fiber. In this study the sequence of pathophysiologic events proposed by the literature is illustrated and a case of thyrotoxic periodic paralysis in a HLA-CW7 positive patient affected by Graves' disease is reported.

Adult↗
PubMedDate not supplied

[Systemic adjuvant chemotherapy of bladder carcinoma with 5 fluorouracil and cyclophosphamide].

Patients with bladder cancer in pT2 and pT3 infiltrating stages have a 5 year survival rate less than 50% after primary surgical and/or radiant therapy. Aim of the present study was to evaluate if adjuvant chemotherapy could improve survival in these subjects. For this purpose, 16 patients underwent treatment with 5-Fluorouracil and cyclophosphamide (min. three, max six courses). The obtained results have shown a 5 year actuarial survival rate of about 48%. Our experience has not shown therefore any improvement compared with primary treatment alone.

Adult↗
PubMedDate not supplied

[Adrenal incidentaloma in a patient operated upon for colon carcinoma].

The extensive use of visualization techniques has allowed the finding of adrenal masses without clinical symptoms in a growing number of patients affected by diseases of different nature. The challenge of these masses, so called incidentalomas, is particularly diagnostic but also prognostic and therapeutic. A flow-chart of proper investigations utilized in a tumoral patient harbouring a left adrenal mass, permitted the correct diagnosis and prognosis.

Adenoma↗