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Biomedical subjects

G Sava

Publications and source records attributed to G Sava.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Antitumor effect of some rhodium(I) derivatives on MCa mammary carcinoma.

The antitumor action of two square planar Rhodium complexes was tested on MCa mammary carcinoma and was seen to depend upon the compound used. The complex cyclooctadiene(2-pyridinalmethylimine)-Rh(I)chloride [Rh(COD)PMI]+ Cl- confirmed the antineoplastic action already shown in the Lewis lung carcinoma model. The examination of the activity of [Rh(COD)PMI]+ Cl- on the lung metastatic tumor indicates that its antineoplastic properties do not seem simply related to a cytotoxic action. It appears more likely that modifications occurring at the primary tumor level, probably different from lethal effects directed to tumor cells, are responsible for the reduction of spontaneous lung metastasis formation observed in the treated animals. The trophic effects observed on the spleen of the treated animals seem to suggest that these compounds are endowed with properties typical of biological response modifiers.

Animals↗
PubMedDate not supplied

Mechanism of the antineoplastic action of lysozyme: evidence for host mediated effects.

The effects of samples of whole plasma obtained from mice orally treated with hen egg-white lysozyme on lung metastasis development were studied in syngeneic CBA animals bearing MCa mammary carcinoma. 50 microliters of whole plasma obtained from mice treated with lysozyme 100 mg/kg/day for 7 consecutive days causes a pronounced and statistically significant reduction of spontaneous lung metastases formed from i.m. implants of MCa mammary carcinoma cells; the use of whole plasma samples prepared from tumor bearing mice is equally effective. The use of 25 microliters of whole plasma or the fractionation of 50 microliters into two injections of 25 microliters is much less effective. No appreciable cytotoxicity for tumor cells was measured by in vivo bioassay of tumor cells kept in vitro with the plasma samples employed. These data indicate that the antitumor activity exhibited by orally administered lysozyme in the treated mice can be totally transferred to other syngeneic hosts through a sample of whole plasma. Furthermore, these results show the intervention of host responses in the antitumor activity of orally administered lysozyme. This conclusion supports the hypothesis put forward that the antitumor activity of oral lysozyme is mediated by the elicitation of host "reactivities", different from lysozyme itself, towards tumor cells, and gives credit to data showing the long lasting antimetastatic effects in mice treated with oral lysozyme 2 weeks before tumor implantation.

Animals↗
PubMedDate not supplied

Inhibitory effects of some organometallic complexes of rhodium(I) and iridium(I) on carrageenin paw edema in rats.

A group of 4 organometallic complexes of Rhodium (I) and 1 Iridium(I) was tested for the evaluation of their anti-inflammatory activity on carrageenin paw edema in rats. All the compounds used inhibited the development of paw edema by more than 50% at different dose-levels. The activity of the pyridinalmethylimine derivative [Rh(COD)PMI]+ Cl- had better results than that of [Rh(NBD)PMI]+ Cl- and even more than the dimeric complexes tested. The higher activity of [Ir(COD)Cl]2 as compared with [Rh(COD)Cl]2 suggests that it would be of interest to examine further Iridium(I) complexes, among which [Ir(COD)PMI]+ Cl- could be a good candidate.

Animals↗
PubMedDate not supplied

Activity and inhibition by cytotoxic and antimetastatic drugs of cathepsin B-like cysteine proteinase in transplantable leukemias in mice.

The cellular levels of cathepsin B-like cysteine proteinases have been determined in a panel of transplantable mouse leukemias possessing a different potential to metastatize to the liver after i.p. implantation. The higher enzymatic activity observed in L1210 leukemic cells matches their higher capacity for hepatic infiltration. No significant difference is observed for TLX5 lymphoma and P388 leukemia, in spite of their different liver invasiveness, and their enzymatic levels do not significantly differ from that of the non-invasive Ehrlich ascitic carcinoma. The in vivo administration of the antimetastatic drugs ICRF159 and DM-COOK, or of the cytotoxic drugs cyclophosphamide, cisplatin, CCNU and GANU, does not cause a pattern of enzyme inhibition matching the tumor metastatic potential and the increase in life-span of the treated tumor bearing mice, indicating that the inhibition of cathepsin B-like cysteine proteinase is not involved in either their cytotoxic or their antimetastatic action.

Animals↗
PubMedDate not supplied

[Operative wounds of the main biliary tract: immediate repair (author's transl)].

The authors report a series of eleven surgical wounds, all immediately repaired. They consider the frequency of these biliary accidents to be 2% in cholecystectomies and 4% in gastrectomies. In such instances end-to-end suture seems the first choice procedure with the best longterm results. They stress the importance of prevention methods that will help to limit the risks of such operative accidents and not to overlook them, should they occur.

Adult↗
PubMedDate not supplied

Antineoplastic effects of egg-white lysozyme in mice bearing solid metastasizing tumors.

The differential effects of the i.v. administration of egg-white lysozyme on primary tumor growth and on the formation of spontaneous and artificial lung metastases have been determined in mice bearing two rodent metastasizing tumors: Lewis lung carcinoma and MCa mammary carcinoma. The depression of metastasis formation was particularly pronounced at 50 and 100 mg/kg/day given on days 1,5,10,15 after tumor transplantation, causing a correspondent prolongation of the life-span of the animals carrying artificial induced lung metastases. Contact between tumor cells and egg-white lysozyme seems at least partially responsible for the observed antitumor effects, although no direct cytotoxicity for tumor cells has been detected yet.

Animals↗
PubMedDate not supplied

Proteinases and proteinase inhibition by cytotoxic and antimetastatic drugs in transplantable solid metastasizing tumors in mice.

The tissue levels of two proteolytic enzymes, plasminogen activator and cathepsin B - like cysteine proteinase, which were found to be increased in malignant tumors and to be proportional to tumor metastatic potential in some instances, have been determined in a panel of solid metastasizing tumors in mice. The examination of B16 melanoma, MCa mammary carcinoma and of two lines of Lewis lung carcinoma with widely different potential to spontaneously metastasize, showed no correlation between metastatic potential and the tissue content of the proteinases considered. The treatment of the animals with cytotoxic antitumor drugs (CCNU, GANU, cisplatin, and cyclophosphamide) or with antimetastatic drugs acting with a mechanism unrelated with cytotoxicity (ICRF 159 and DM-COOK) caused only marginal inhibition in some instances, whereas no meaningful pattern of inhibition either based in terms of metastatic potential of the tumor or on drug mechanism of action was recognizable. A direct involvement of the two proteinases examined in the process of metastasis in the tumor panel used is thus not apparent, although a more complex interaction with other latent proteinases and inhibitors might be operative.

Animals↗
PubMedDate not supplied

Antineoplastic activity of planar rhodium(I) complexes in mice bearing Lewis lung carcinoma and P388 leukemia.

The antitumor effects of three rhodium(I) complexes were evaluated using two transplantable tumors of the mouse: Lewis lung carcinoma and P388 lymphocytic leukemia. The examination of the differential effects on primary tumor growth and on the formation of spontaneous pulmonary metastases, in mice bearing Lewis lung carcinoma, indicated that the complex having qualitatively the higher solubility in aqueous solutions and the higher resistance to inactivation via oxidation, displayed the more pronounced antineoplastic activity. The antileukemic effects, in mice bearing P388 lymphocytic leukemia, also seemed to depend on the chemical characteristics of the complex used, and the previously reported trend was particularly evident using an acute treatment performed 24 hr after tumor transplantation.

Animals↗
PubMedDate not supplied

Effects of dimethyltriazenes combined with surgery and non-specific immunotherapy in mice bearing Lewis lung carcinoma lines.

The therapeutic efficacy of the preoperative administration of DTIC and its benzenoid analog DM-COOK, in terms of prolongation of the life-span of mice bearing Lewis lung carcinoma lines with different metastatic potential, has been evaluated in combined experiments with surgery and postsurgical non-specific immunotherapy with the peptidoglycan monomer PGM. The effects of the presurgical selective antimetastatic treatment with the dimethyltriazenes consist of a statistically significant prolongation of the survival time of the treated mice. The activity is more pronounced, in terms of animals cured, using the tumor line which is endowed of a low ability to colonize the lungs. The addition of postsurgical immunotherapy with PGM improves the overall therapeutic efficacy of the combined treatment with triazenes and surgery, independently from the tumor line used. In general, the presurgical treatment with the benzenoid triazene DM-COOK, causes antineoplastic effects slightly better than those observed using the imidazole derivative DTIC.

Amputation, Surgical↗
PubMedDate not supplied

Therapeutic activity of ICRF-159 combined with surgery: effects of postsurgical treatment with cyclophosphamide in mice bearing Lewis lung carcinoma lines.

The therapeutic activity of the combined treatment with surgery and ICRF-159, measured in terms of increase of the survival time, has been tested in mice bearing two Lewis lung carcinoma lines having different potential to spontaneously metastasize (M1087 high; BM21548 low). As expected from the characteristics of this drug, a significant prolongation of the survival time of the treated hosts can be achieved only after presurgical treatment; the overall effect is greater using the tumor line with low metastatic ability. The response of the two tumor lines used to postoperative treatment with Cyclophosphamide also depends upon the tumor line used. The preoperative treatment of the animals with ICRF-159 markedly increases the response to Cyclophosphamide of the low responding M1087 line.

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