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G Santini

Publications and source records attributed to G Santini.

212 records · Page 12Linked to original sources
PubMedDate not supplied

[Comparative evaluation of 3 tests for the determination of antistreptolysin titer].

We have evaluated three commercial assays for ASLO titer determination Actually a hemolysis inhibition plate micromethod (ASLO Pasteur), an automated method based on kinetic measurement of an haemolytic reaction (TASOMATIC/TASOTEC, Diagnostica Senese), and another automated assays using the nephelometric quantitation of a latex particle agglutination.

Antibodies, Bacterial↗
PubMedDate not supplied

[Case of Listeria monocytogenes meningitis with a benign course in a healthy adult].

We herein describe the case of Lysteria monocytogenes meningitis. The isolation and identification of the bacteria causing the infection ollowed the antibiotic treatment followed by complete remission. Our data also support the hypothesis on intense immunological response producing a favourable evolution of the disease.

Ampicillin↗
PubMedDate not supplied

Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia.

BACKGROUND: Several reports showed that mixed cryoglobulinemia (MC) is closely associated with hepatitis C virus (HCV) infection. Since several authors reported the efficacy of alpha-interferon in the treatment of MC, we investigated the long-term effects of this drug on clinical, hematological and virological parameters in a group of 18 patients (13 women and 5 men, mean age 56 +/- 11 years) affected by MC. METHODS: A bone marrow biopsy was performed in all patients, and a liver biopsy was obtained in those with biochemical signs of chronic liver disease. The presence of HCV-RNA in serum was assessed by detection of anti-HCV antibodies and by PCR amplification of the 5' untranslated region of HCV. All patients followed the same treatment schedule: three million units of recombinant interferon alpha-2b s.c., three times a week for 1 year. RESULTS: In 5 cases bone marrow histology showed the presence of a monoclonal lymphocytic infiltrate. Liver biopsies were performed in 13 (72%) of the patients and a chronic liver disease was found in all 13. Anti-HCV antibodies were present in 17 (95%) subjects. HCV-RNA was detected in all cases (100%) before therapy. Five (28%) patients achieved a complete response and 9 (50%) a partial response, while the others (4 cases, 22%) showed minor responses. Four patients cleared the virus and obtained a complete remission of the MC. CONCLUSIONS: HCV may be a cause of MC. The disease is associated with a high incidence of monoclonal lymphocytic infiltrate of the bone marrow. Alpha-interferon seems to be an effective agent for the treatment of MC.

Adult↗