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Biomedical subjects

G Sansone

Publications and source records attributed to G Sansone.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Relative ratios of lactoferrin, albumin, and acid phosphatase seminal levels as sperm quality markers in fertile and infertile men.

Human seminal plasma proteins from fertile and infertile men were fractionated by electrophoresis. The amounts of three Coomassie-stained protein bands were measured by densitometry. Their relative ratios were constant in normospermic men but varied in the infertile patients. Laboratory manipulation of the semen was shown not to affect the protein ratios as observed after liquefaction, incubation at various temperatures, and storage at -20 degrees C. The three proteins were purified by chromatographic techniques and identified as lactoferrin, albumin, and acid phosphatase by electrophoresis, high-pressure liquid chromatography, and enzyme assays. The use of these proteins to evaluate the contributions of different fluids to seminal plasma is discussed.

Acid Phosphatase↗
PubMedDate not supplied

The Italian contribution to the study of Fanconi's anemia.

All the papers of the Italian authors on Fanconi's anemia are carefully listed. In the meantime some data of an epidemiological inquiry on the Italian unpublished cases are notified. They are as follows: i) the frequency of the disease is higher than it could be suspected; ii) the regional distribution is not homogeneous, with areas of higher density in Southern Italy, especially in Campania; c) the mean survival of the patients is significantly increased in comparison with the past; d) the prevalence of malignant complications is inexplicably low, as compared with non-Italian cases. A national Registry on Fanconi's anemia is proposed.

Fanconi Anemia↗
PubMedDate not supplied

Congenital refractory anaemia with vacuolisation of bone marrow precursors, sideroblastosis and growth failure in a girl with normal endocrine pancreatic function.

The case is described of an 8-years-old girl with consanguineous parents. She was apparently well, apart, from growth retardation, until 18 months of age when she developed severe normocytic hypochromic anaemia. Bone marrow examination revealed vacuolisation of the erythroid and myeloid precursor, and electron microscopic studies showed striking sideroblastosis with ringed arrangement of the iron granules. Porphyrin metabolism was apparently normal, whereas blood levels of iron and ferritin were high. A careful study of the exocrine pancreas showed completely normal function. Vitamin B6 administration was unsuccessful. The patient is transfusion-dependent, and iron chelation treatment has produced good results. The case could be a new entity or a variant of congenital sideroblastic anaemia, since it has some features in common with the syndrome described by Pearson et al.

Anemia, Refractory↗
PubMedDate not supplied

[Yersinia enterocolitica sepsis in splenectomized thalassemic subjects. Description of 2 cases].

Two cases of Yersinia enterocolitica septicemia in two splenectomized children with thalassemia major are reported. Human Yersinia enterocolitica septicemia is an uncommon condition, but its frequency may increase in patients having debilitating diseases or blood disorders, as well as a consequence of the splenectomy. Some brief considerations on the pathogenetic factors yielding, to severe infections in splenectomized thalassemic children are discussed. The high number of thalassemic people in Italy makes necessary an early diagnosis in case of septicemia. Particularly important is the blood culture, because of the slowness of the microbic development in stools.

Child↗