Dynamic and chronobiological changes of endocrine indices in myotonic dystrophy.
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Adolescent↗
Biomedical subjects
G Sances
Publications and source records attributed to G Sances.
Epileptic seizure during aspirin and caffeine withdrawal in a drug induced headache.
A 45-year-old female migraineur with a long-standing history of drug-induced headache is described. She had been abusing caffeine (250 mg/day) and aspirin (5 gr/day). On the third day after discontinuation a withdrawal syndrome characterized by headache and a generalized tonic-clonic seizure occurred. The temporal association makes it likely that the convulsion episode in an integral component of the withdrawal syndrome in this patient. This extra feature of the withdrawal syndrome has never been described after caffeine and/or aspirin interruption. Possible pathogenetic mechanisms are discussed.
Anti-Inflammatory Agents, Non-Steroidal↗
The effects of physical exercise at high altitude on adrenocortical function in humans.
The combined effects of sustained physical activity and hypoxia on adrenocortical function were investigated in 14 healthy volunteers, 8 males and 6 females (mean age 40.9 +/- 3.3 years), during a scientific expedition in the Himalayas. Plasma cortisol levels were measured in all subjects in basal conditions and after the administration of 1 mg dexamethasone (DXM) p.o. The study was performed before and after 15 days of intense trekking (Leh, altitude 3700 m). While on both occasions subjects retained their cortisol circadian fluctuations, basal and post-DXM cortisol levels at high altitude were significantly higher (p < 0.005 and p < 0.0005) than before climbing. Cortisol suppression was noted in all cases at low altitude, whereas 4 out of the 14 subjects did not show reduced hormone levels after 15 days of trekking. Moreover, nonsuppressor subjects had significantly higher (p < 0.05) baseline cortisol levels than suppressors. Basal and post-DXM hormone levels were found to be unrelated to age and sex of subjects. The present data further suggest that sustained physical activity at altitude activates adrenocortical function in normal individuals; however, in 30% of subjects DXM-induced cortisol suppression does not occur. To explain the latter observation, the concomitant role of hypoxia (and/or other environmental changes) and the subjective perception of physical stressors should be taken into account.
Adrenal Cortex↗