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Biomedical subjects

G Salvatore

Publications and source records attributed to G Salvatore.

100 records · Page 6Linked to original sources
PubMedDate not supplied

[Structural modifications and hematic variations in pregnant and/or suckling rats kept on a purified diet with high content of animal proteins].

The effects of a high protein diet (casein 40%, lactalbumin 20%) were evaluated in pregnant and/or suckling rats. Histological studies of the organs showed structural alterations to the liver, adrenal cortex, kidneys and heart accompanied by significant metabolic changes in blood glucose and triglyceride levels. Overall the experimental results encourage the belief excessive intake of animal protein, particularly at an early stage, may do specific damage to the normal course of pregnancies, given the low birth rate and high incidence of perinatal mortality observed in the offspring produced by mothers given high protein diets throughout pregnancy.

Adrenal Cortex↗
PubMedDate not supplied

The effects of roxatidine on neuromuscular transmission.

We have investigated the effects of the H2 receptor antagonist roxatidine on the neuromuscular transmission by using the sciatic nerve-gastrocnemius muscle preparation of the rat in vivo. Roxatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by roxatidine is partially reversed by 4-aminopyridine but not by dimaprit.

4-Aminopyridine↗
PubMedDate not supplied

Antitumor and cardiotonic activity of imidazo[2,1-b]thiazole guanylhydrazones.

A number of imidazo[2,1-b]thiazole guanylhydrazones, whose antitumor activity has already been described, were tested as potential cardiotonic agents. The guanylhydrazone of 2,3-dihydro-6-chloroimidazo[2,1-b]thiazole-5-carboxaldehyde (2a) was the most interesting compound showing both antitumor and cardiotonic activity.

Animals↗
PubMedDate not supplied

Reduction of adriamycin cardiotoxicity by enoximone.

Several non catecholamine, non glycoside cardiotonic drugs have been described recently. New compounds include amrinone, sulmazole, milrinone and pimobendan. In an attempt to alleviate or prevent anthracycline toxicity, we have reported that these compounds reduce the negative effects of adriamycin, 4-epiadriamycin and esorubicin in isolated guinea pig atria. The present study reports the effects of a new cardiotonic agent: enoximone. Enoximone was administered after adriamycin (100 micrograms/ml) on the isolated and spontaneously beating atria, and on electrically driven left atria of guinea pig-in normodynamic and hypodynamic conditions. Exposure for 60 minutes to the antitumor drug causes a depression of contractile force (g) and its derivative versus time (dF/dt, as maximal rate of contractile force). The negative effects of adriamycin are antagonised by enoximone (100, 200 micrograms/ml).

Animals↗