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Biomedical subjects

G Saito

Publications and source records attributed to G Saito.

At least 37 records · Page 2Linked to original sources
PubMed1994

Suppression of plasma glutathione peroxidase activity by ifosfamide.

Plasma glutathione peroxidase (GPx) is synthesized predominantly in the kidneys. Plasma-GPx activities were measured in 12 patients with gynecological malignancies before and after chemotherapy. The patients were treated with cisplatin alone (P); with VP16 and cisplatin (EP); with cyclophosphamide, doxorubicin, and cisplatin (CAP); or with ifosfamide, doxorubicin, and cisplatin (IAP). The protein levels of the enzyme were semi-quantitatively determined by immuno-blot analysis. Plasma GPx activity was decreased by an average of 61% (p < 0.01) in patients treated with IAP, while no significant decreases were observed in patients treated with any drug combinations without ifosfamide. Immuno-blot analysis of plasma samples from a patient treated with IAP revealed no differences in the protein levels of plasma GPx either before or after IAP administration, although the plasma GPx activity decreased 83%, from 0.173 to 0.029 units/ml. The results indicate that the decrease in plasma GPx activity was not due to impaired production of the enzyme in the kidneys, and that ifosfamide is responsible for inhibition of the enzyme activity. Since GPx is an enzyme of major importance in detoxification of lipid peroxides in the brain, CNS toxicity induced by ifosfamide might be related to severe suppression of plasma GPx activity.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1994

[Prediction of lowest PaO2 during unilateral whole lung lavage in a patient with pulmonary alveolar proteinosis--unilateral ventilation with nitrogen].

Unilateral whole lung lavage (UWLL) was performed four times in a patient with pulmonary alveolar proteinosis. PaO2 was 94 Torr even under ventilation with 100% O2. Because of the difficulty in providing adequate arterial oxygenation, extracorporeal membrane oxygenation (ECMO) was indispensable in accomplishing the first right UWLL. During the second left UWLL, the left lung was ventilated with nitrogen (N2) and an attempt was made to predict the lowest PaO2 occurring during lavage in order to establish criteria for the use of ECMO during UWLL. When both lungs were ventilated with 100%. O2, PaO2 rose to 150 Torr. PaO2 fell to 65 Torr after ventilation of the left lung with N2 while the right lung was ventilated with 100% O2 for 7 minutes. The N2 was replaced with 100% O2 and ventilation was continued for another 10 minutes to wash the N2 out of the left lung. When the tracheal tube in the left lung was clamped for 7 minutes for degassing, PaO2 fell to 59 Torr. Subsequently 1,200 ml of physiological saline was injected into the left lung, and PaO2 rose to 155 Torr. A 6 Torr difference was found between the value of PaO2 under ventilation with N2 and that of degassing, but this difference was not statistically significant. The lowest PaO2 occurring during UWLL was considered to be predictable if the unilateral lung was ventilated with N2.

Extracorporeal Membrane Oxygenation↗