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Biomedical subjects

G S Watson

Publications and source records attributed to G S Watson.

11 recordsLinked to original sources
PubMed1977

Age incidence curves for cancer.

Age incidence curves for carcinomas tend to be linear on doubly logarithmic graphs. This fact has been used to support the somatic mutation hypothesis. It is shown that this should also be expected on the epigenetic hypothesis when the reversible cellular changes are programmed to occur randomly. Such changes could be programmed differently to obtain the age incidence curves observed for other cancers, e.g., leukemias and sarcomas.

Age Factors↗
PubMed1976

Cytogenetics and infertility in man. II. Testicular histology and meiosis.

Within a group of 207 subfertile men, selected for testicular biopsy, histological investigations were made successfully in 194 chromosomally normal and 7 chromosomally abnormal individuals. Fifty-two per cent of men with a normal karyotype showed normal testicular histology, 31% showed a general depression of spermatogenesis and 8% showed deficiency in the late stages. Ten per cent had only Sertoli cells in the testis. The range of testicular conditions seen in the chromosomally abnormal men was similar to that found in the chromosomally normal. Meiotic studies carried out on 118 chromosomally normal individuals gave a mean chiasma count of 48-9 per cell. There was a positive correlation between high numbers of cells at diakinesis/metaphase I showing X and Y univalents and low numbers of cells reaching metaphase II. Meiosis was studied in 3 translocation heterozygotes, one 47, XYY male, one 47, XY+mar individual and one patient with a ring Y chromosome.

Adult↗
PubMed1975

Lymphocytotoxins in vasectomized men.

Serum samples before and after vasectomy were examined for cold and allogeneic lymphocytotoxic antibodies. The techniques used did not demonstrate a significant increase in the incidence of these antibodies following vasectomy.

Antibodies↗