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G S Tell

Publications and source records attributed to G S Tell.

60 records · Page 4Linked to original sources

Studies of atherosclerosis determinants and precursors during childhood and adolescence.

At a Meeting of Investigators on Epidemiological Studies of Atherosclerosis Determinants and Precursors, which was held in Geneva on 7-9 November 1983, representatives from 26 countries reviewed the current status of epidemiological studies in this area. Particular interest was shown in the following determinants of cardiovascular disease: blood pressure, blood lipid levels, body weight, pathological studies, and tobacco use. Working papers on each determinant were prepared, and recommendations were made on areas for research, and on the need for prevention programmes and pathological studies. This article summarizes the work of the meeting.

Adolescent↗

Cardiovascular disease risk factors related to sexual maturation: the Oslo Youth Study.

This paper focuses on cardiovascular disease risk factors as they are influenced by sexual maturation. Serum total cholesterol, HDL-cholesterol, fasting triglycerides, blood pressure, height, weight and triceps skinfold thickness were investigated longitudinally in a population of 550 Norwegian adolescents aged 10-14 years at the onset. Two identical surveys were conducted, the first in 1979 and the last in 1981. Included in the study was a measure of developmental age, assessed by using sex maturity ratings formalized by Tanner. The physiological endpoints (except triglycerides) were more strongly related to developmental age than to age in years. Among 11 and 12 year old males, values not adjusted for sexual maturation stage underestimated height, weight and blood pressure and overestimated skinfold thickness, total cholesterol and HDL-cholesterol. In 15 and 16 year old males, unadjusted values overestimated height, weight and blood pressure, and underestimated total and HDL cholesterol. For females, unadjusted values underestimated height, weight, body mass index, triceps skinfold thickness and blood pressure among 11-12 year olds and overestimated the same variables for 15 and 16 year olds. These findings indicate that for adolescents, an index of physiological development more precise than chronological age should be included in epidemiological studies.

Adolescent↗

Cholesterol, high density lipoprotein cholesterol and triglycerides during puberty: the Oslo Youth Study.

The relationships of serum total cholesterol, high density lipoprotein (HDL) cholesterol and fasting triglycerides (adjusted for body mass index, wt/ht2) with stages of pubertal development were examined in a Norwegian population of 920 adolescents, aged 10 to 16 years. For 13- and 14-year-olds, all five stages of Tanner's maturity index were represented. For the whole population, total serum cholesterol showed a larger decrease when related to sexual maturity stage than to chronologic age. For females, HDL cholesterol and triglycerides increased significantly when related to age in years; this was not found when related to the maturity index. Triglycerides showed a larger increase when related to chronologic age in males as compared with sexual maturity stage. Both among 13- and 14-year-old males, the most mature had significantly lower values for total cholesterol than the least mature. For 12-year-old males, HDL cholesterol decreased significantly with increasing sexual maturation. Among females, the more mature 12-year-olds had significantly lower values for total cholesterol compared with the less mature. Early maturing 13-, 14- and 15-16-year-olds had lower levels of HDL cholesterol compared with late maturers. These findings suggest that age in years may be a poor index of development in adolescents and that a measure of physiologic developmental age should be included in epidemiologic studies of serum lipids among adolescents.

Adolescent↗

The relationship of white cell count, platelet count, and hematocrit to cigarette smoking in adolescents: the Oslo Youth Study.

This article reports on the relationship between cigarette smoking, white blood cell count (WBC), platelet count (PC), and hematocrit in a Norwegian adolescent population. Data were obtained on 439 youths, 14 to 16 years old, as part of the Oslo Youth Study, an investigation of risk factors and behaviors for cardiovascular disease and cancer among adolescents. Analyses of covariance, controlling for height, weight, age, sexual maturation, high-density lipoprotein (HDL) cholesterol, and hematocrit revealed that both male and female regular smokers (those reporting smoking at least once a week) had significantly higher mean WBCs. Male regular smokers also had significantly higher PCs than nonsmokers, and female regular smokers had higher PCs than young women who smoked less often than once a month. Hematocrit, after adjustment for height, weight, age, sexual maturation, and HDL cholesterol, was significantly lower in male regular smokers, while female regular smokers had higher hematocrit values than nonsmokers or occasional smokers. Results of this study show that WBC and PC were increased in adolescents who started smoking relatively recently. This indicates that the increase in white cell count observed in smokers is unlikely to be due to a longstanding smoking-induced chronic disease condition.

Adolescent↗

Preventing the onset of cigarette smoking in Norwegian adolescents: the Oslo youth study.

As part of a 2-year multiple risk factor intervention study, a school-based, multicomponent smoking prevention program for 10- to 15-year-old students in Oslo, Norway, resulted in a significant reduction in the onset of smoking relative to a reference group. Based on reported smoking behavior, the intervention group (N = 278) experienced a smoking onset rate of 16.5% and the reference group (N = 208) a rate of 26.9%. Intervention students had a significantly larger increase in scores on a smoking knowledge index; they also reported a significantly larger increase in frequent exercise and a significantly smaller increase in consumption of alcoholic beverages. A stepwise discriminant analysis showed that the smoking prevention program was an important discriminator of smoking onset. In both reference and intervention groups, students who reported smoking at the follow-up survey had already displayed risk-taking tendencies at the time of the baseline survey 2 years earlier, whether or not they smoked at baseline. Follow-up smokers had more smoking friends and siblings at baseline and evidenced greater acceptability of smoking; they ate sweet, fatty, and salty snack foods more often, exercised less often, and drank more beer and hard liquor than students who were nonsmokers at the follow-up survey.

Adolescent↗