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Biomedical subjects

G S Moss

Publications and source records attributed to G S Moss.

At least 109 records · Page 6Linked to original sources
PubMed1976

Transport of oxygen and carbon dioxide by hemoglobin-saline solution in the red cell-free primate.

This study was undertaken to investigate the respiratory properties of hemoglobin-saline solution. Eighteen baboons were exchange transfused with either 6 per cent dextran or 6 per cent hemoglobin-saline solution. All of the hemoglobin-saline solution treated baboons survived three hours at a zero hematocrit reading. All the dextran treated animals died when the hematocrit level fell below 6 per cent. Oxygen consumption and carbon dioxide production remained unchanged from base line during the zero hematocrit interval. It is concluded that the respiratory capability of hemoglobin-saline solution is sufficient to maintain life in the absence of erythrocytes.

Animals↗
PubMed1975

Scope and limitations of stroma-free hemoglobin solution as an oxygen-carrying blood substitute.

One hundred years of study of stroma-free hemoglobin have generated much information regarding its scope and limitations as an oxygen-carrying blood substitute. The most important development in recent years is the development of a truly stroma-free hemoglobin solution. At this time, we know that SFH can readily bind, transport, and unload oxygen. It does not appear to be nephrotoxic or significantly antigenic. It may not be converted to methemoglobin in the body in significant amounts. Its short in vivo half-life may have important advantages.

Animals↗
PubMed1975

The normal electron histochemistry and the effect of hemorrhagic shock on the pulmonary surfactant system.

An electron histochemical study was carried out on eight baboons to localize the phospholipid constituent of pulmonary surfactant in the normal state and after hemorrhagic shock. In the normal state, phospholipid was seen as a continuous layer lining the alveolar spaces. Phospholipid also was seen in the inclusion bodies of the granular pneumocytes, suggesting these cells as the site of production of surfactant. After hemorrhagic shock, the previously continuous phospholipid layer lining the alveolar spaces became totally fragmented. In addition, increased numbers of phospholipid particles were seen within the pulmonary interstitium. The results of this study suggest that the pulmonary surfactant system may be impaired after hemorrhagic shock.

Animals↗