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G S May

Publications and source records attributed to G S May.

59 records · Page 4Linked to original sources
PubMed1980

Clinical trials of platelet-active drugs in coronary heart disease: summary of design features.

The basic design features of eight clinical trials of platelet-active drugs in the secondary prevention of myocardial infarction are reviewed. Study populations are compared with regard to size, time of enrollment after the qualifying infarction and the length of follow-up. Differences in the drug regimens in terms of dose are given and there are comments on the selection of response variables, the withdrawal of patients from analysis and repeated significance testing.

Aspirin↗
PubMedDate not supplied

Mitosis in wild-type and beta-tubulin mutant strains of Aspergillus nidulans.

We review and illustrate the wild-type mitotic cycle of Aspergillus nidulans and report the sequence alterations in six mutant alleles of the A. nidulans benA, beta-tubulin, gene. These alleles confer heat sensitivity and resistance to the antifungal, antimicrotubule compound benomyl, and they have been very important in the study of mitosis and microtubule function in A. nidulans. The mutations are novel and fall at amino acids 50, 134, and 257. We have examined the phenotypes conferred by the mutations at restrictive temperatures. None blocks the assembly of microtubules. One allele, benA33, blocks anaphase A and partially inhibits the disassembly of cytoplasmic microtubules in mitosis. We also often observe abnormal spindle morphologies in strains carrying benA33. Another allele, benA31, causes arrest in mitosis with short mitotic spindles and, thus, appears to inhibit spindle elongation.

Alleles↗