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Biomedical subjects

G S Harris

Publications and source records attributed to G S Harris.

At least 55 records · Page 3Linked to original sources

Retinopathy of prematurity and retinal detachment.

A group of 39 patients with retinopathy of prematurity or retrolental fibroplasia have been evaluated. Nine of these were prematures at the time of their examination and showed severe bilateral disease. One eye in each patient was treated with the other eye serving as a control using either Xenon photocoagulation or cryocoagulation. It will take many years to observe the effect of this form of therapy but initial changes suggest alterations in the amount of retinal traction and in the appearance of blood vessels at the posterior pole in some of the treated patients. Thirty older patients have been assessed and of these, 18 eyes developed retinal detachments. Of the 16 operated upon, 87% had successful scleral buckling surgery. Three additional patients had similar retinal findings to retrolental fibroplasia but no history of prematurity or oxygen therapy. These patients were not included in this study. Retinopathy of prematurity is much less common now that it was 2 decades ago, but still represents a significant cause of ocular morbidity and blindness.

Adolescent↗

Pheochromocytoma and von Hippel-Lindau's disease.

Two families with von Hippel-Lindau's disease with associated pheochromocytoma are presented. We include a review of the literature on this association, and discuss its significance for the ophthalmologist.

Adolescent↗

Canine systemic lupus erythematosus. Transmission of serologic abnormalities by cell-free filtrates.

The presence of viruses was sought in a colony of dogs bred from parents with systemic lupus crythematosus (SLE). Cell-free filtrates prepared from the spleens of these animals were injected into newborn dogs, mice, and rats. The canine recipients developed antinuclear antibody (ANA) and positive lupus erythematosus (LE) cell tests: ANA and, in some cases, antinative DNA antibodies were produced by the murine recipients: no abnormalities were detected in the rats. Serial passage of spleen cells or cell-free filtrates of spleen tissue in syngeneic mice reduced the time required for appearance of ANA from 9 to 4 mo. Some murine recipients of the canine filtrate developed malignant lymphomas. Murine leukemia viruses were identified in these tumors by electron microscopic, virologic, and serologic technics. These neoplasms, but not other tumors known to contain murine leukemia viruses, were associated with the production of ANA. Puppies inoculated with the canine filtrate-induced mouse lymphoma developed ANA and positive LE cell tests within 4 mo. THE RESULTS WERE INTERPRETED TO INDICATE THE PRESENCE IN CANINE SLE OF A VIRUS CAPABLE OF: (a) inducing the serologic abnormalities of SLE in normal dogs and mice: (b) activating latent murine leukemia viruses: and (c) spreading by both horizonal and vertical routes.

Animals↗