The intraluminal distribution of 15-micrometer-diameter carbonized microspheres within arterial microvessels as determined by vital microscopy of the golden hamster cheek pouch.
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Animals↗
Biomedical subjects
G S Harell
Publications and source records attributed to G S Harell.
CT-pathologic correlations in Hodgkin's disease and non-Hodgkin's lymphoma.
In order to assess its potential uses in the staging and treatment planning of lymphoma, CT was performed in 27 newly diagnosed, previously untreated patients with Hodgkin's disease or non-Hodgkin's lymphoma; 18 staging laparotomies provided pathologic correlations. CT detected and defined disease in areas not well evaluated by conventional techniques (high para-aortic, mesenteric, splenic hilar nodes). CT interpretation of splenic size and weight correlated well with splenic weight confirmed at pathology. Nodules were identified in several spleens containing foci of lymphoma.
Adolescent↗
Profile roentgenographic features of benign greater curvature ulcers.
Certain roentgenographic features have been considered typical of benign gastric ulcers, based almost entirely on studies of the lesser curvature. However, these features frequently are not present on the profile view in benign greater curvature ulcers. Moreover, features stated to suggest malignancy in gastric ulcers are commonly simulated by benign greater curvature ulcers. The authors reviewed the profile roentgenographic features of 19 benign greater curvature ulcers and found that they often appeared to be intraluminal and had shouldered edges due to spasm of the surrounding circular muscles. In 6 patients the adjacent gastric contour was scalloped. These features frequently cause radiologists to misinterpret benign greater curvature ulcers as malignant.
Diagnosis, Differential↗
Non-beta islet cell tumor calcification assoicated with Zollinger-Ellison syndrome and multiple endocrine adenomatosis.
The radiographic triad of a calcified pancreatic mass, duodenal ulcers, and nephrocalcinosis should suggest the Zollinger-Ellison syndrome, as part of the multiple endocrine adenomatosis complex. The clinical and radiographic features of the entity are described in this case report.
Adenoma↗
The simultaneous visualization of microspheres and blood flow in the microvascular bed of the hamster cheek pouch.
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Animals↗
Early experience with the Varian Six Second body scanner in the diagnosis of hepatobiliary tract disease.
Thirty-four patients with liver disease were studied with a research model of the Varian Six Second body scanner. Useful information was gained in patients with a variety of hepatic disorders. This scanner permits resolution of normal hepatic parenchymal detail which has not been reported previously and has reduced the streak artifacts originating from high- and low-CT objects which have been a major source of image degradation with other units.
Adult↗
Stop-action cardiac computed tomography.
Computed tomographic (CT) cardiac imaging in vivo has been hampered by motion of the heart during its cardiac cycle. A technique of post data-acquisition correlation of the angular projection data using the electrocardiogram as a reference signal is described. This method produced seven "stop action" images of the heart and resulted in delineating morphological detail not recognizable on the conventional CT scan.
Electrocardiography↗
Computed tomography of abdominal paraaortic lymph node disease: preliminary observations with a 6 second scanner.
Eleven patients suspected of having tumor involving para-aortic lymph nodes were studied with the Varian 6 second whole body CT scanner. All patients had a pedal lymphangiogram; six were abnormal. In three of these six, CT provided clinically important information on the extent of disease which was not detectable by other radiographic studies. CT scanning improved on lymphangiographic interpretation when large bulky nodes were only partially filled and when whole chains of nodes failed to fill. In both situations, the enlarged paraaortic nodes were well delineated on CT. The internal architecture and morphological abnormalities of small well filled nodes were better portrayed by lymphangiography. In the four cases in which lymphangiograms were normal and the one case in which the lymphangiogram showed reactive hyperplasia, the CT scans were normal.
Adult↗
Computed tomography of the abdomen in the malignant lymphomas.
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Abdominal Neoplasms↗
Upper esophageal responses to intraluminal distention in man.
This investigation determined the site(s) of elicitation and origin of secondary peristalsis in the human esophagus and characterized the upper esophageal sphincter (UES) and proximal esophageal body responses accompanying intraluminal distention. In 7 normal persons, an intraluminal transducer probe manometrically recorded the UES and 5- and 10-cm levels of the esophageal body. A second probe with a balloon attached 2 cm above the proximal strain gauge was located so that the balloon was 3 and 4 cm below the UES and 4 distentions were done. The balloon probe was moved in 2-cm increments (four distensions at each site) until lower esophageal sphincter pressures were recorded. No secondary peristalsis occurred after distention in the proximal 6 cm. The incidence of secondary peristalsis increased as the distention site moved distally. Sixty-nine per cent of secondary peristaltic waves orignated in the esophageal body proximal to the distention site. The UES pressure significantly increased over resting pressure (augmentation) during 63% of distentions. The esophagus proximal to the balloon and below the UES usually responded to distention with augmentation. Augmentation of the UES and proximal esophageal body in response to esophageal intraluminal distention and the resultant initiation of secondary peristalsis above the distention site comprise a highly integrated pressure barrier to esophagopharyngeal reflex.
Adult↗
Tumefactive extramedullary hematopoiesis of the stomach.
A 3 X 4 cm submucosal gastric mass of extramedullary hematopoeitic tissue occurred in a patient with chronic myelogenous leukemia. Such stomach masses have been misinterpreted as malignant tumor. Tumefactive extramedullary hematopoiesis of the stomach is an infrequent occurrence in patients with extramedullary hematopoiesis but should be considered in the differential diagnosis of patients known to have this condition.
Adult↗
Multiple "bull's-eye" lesions in gastric lymphoma.
Three adolescent patients with multiple gastric target lesions and gastric lymphoma are reported. Each had either histiocytic or poorly differentiated lymphoma. The literature was reviewed to ascertain whether multiple gastric lymphomatous target lesions were confined to adolescent patients or to patients with a particular histologic subtype. Review of 119 cases in the literature did not support either hypothesis.
Adolescent↗
Sequential feline esophageal nutrient blood flow: perfusion measurements in vivo.
The utilization of a catheter semiconductor beta detector (CASRAD) to perform in vivo, sequential, esophageal nutrient blood flow distribution studies in cats is described. A diffusable radioisotope, Rubidium 86 (86Rb), was injected intravenously and the CASRAD placed within the esophageal lumen. The distribution of 86Rb remained stable within the feline esophagus for sufficient time to allow for counting at 1.5 cm levels in the esophagus. The accuracy limitations of the CASRAD system were assessed by comparing the in vivo, recorded distribution of 86Rb with the esophageal distribution of 86Rb as determined by a well-type scintillation counter. The distribution throughout most of the esophagus was similar by both techniques. Sequential esophageal studies performed with the CASRAD showed less variability than existed in the biological differences between cats and the methodology of obtaining and counting tissue by well-type scintillation counter (mean coefficient of variation 11.6% versus coefficient of variation 23.1%).
Animals↗
Dynamic response criteria for fluid-filled esophageal manometers.
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Esophagus↗
Diameter of arterial microvessels trapping 8--10 micron, 15 micron and 25 micron microspheres as determined by vital microscopy of the hamster cheek pouch.
An assumption inherent in the use of microsphere methodology for measuring regional blood flow is that microspheres are removed from the circulation by impacting in arterial vessels of approximately their own diameter. We investigated the in vivo relationship between the diameter of varying size microspheres and the calibre of trapping microvessels within the hamster cheek pouch. Intracardiac injection of 8-10, 15 +/- 5, 25 +/- 5 micron carbonized microspheres with diversion of the cardiac output into the bracheocephalic trunk provided direct, in vivo visualization of the impaction sites of these various size microspheres within the cheek pouch microvasculature. Fifteen micron microspheres usually impacted at the orifice or neck of small arterioles and protruded into the lumen of the parent vessel. Eight to ten micron microspheres lodged in vessels with a mean diameter of 11.5 +/- SD 3.4 micron indicating that they usually impacted primarily in terminal arterioles.
Animals↗