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Biomedical subjects

G S Bulmer

Publications and source records attributed to G S Bulmer.

42 records · Page 3Linked to original sources
PubMed1968

Cryptococcus neoformans. 3. Inhibition of phagocytosis.

Isolated nonhydrolyzed cryptococcal polysaccharide is a rather specific potent inhibitor of the phagocytosis of Cryptococcus neoformans by human leukocytes in vitro. When an encapsulated strain of C. neoformans was cultured in the nonencapsulated state, the rate of phagocytosis was three times greater than when the encapsulated form was used. Our theory that capsular material plays a role in the pathogenesis of cryptococcosis requires (i) that C. neoformans exist in soil in a nonencapsulated state and (ii) that human phagocytes be capable of killing the organisms.

Candida↗
PubMed1967

Cryptococcus neoformans. I. Nonencapsulated mutants.

Seven nonencapsulated mutants of Cryptococcus neoformans were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted to the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the presence of a capsule and the virulence of C. neoformans.

Animals↗
PubMed1967

Cryptococcus neoformans. II. Phagocytosis by human leukocytes.

Twenty-four per cent of the leukocytes from healthy human subjects phagocytized an encapsulated strain of Cryptococcus neoformans. Phagocytosis was approximately three times more effective with nonencapsulated mutants of C. neoformans. When the mutants reverted to the encapsulated state, the percentages of phagocytosis decreased. These data indicate that cryptococcal polysaccharide inhibits the phagocytosis of C. neoformans by human leukocytes.

Cryptococcus↗