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Biomedical subjects

G Rusu

Publications and source records attributed to G Rusu.

29 records · Page 2Linked to original sources

Two multidimensional methods applied to the study of cardiovascular risk factor.

In the epidemiologic study of chronic diseases, especially that of cancer and heart disease, it is often necessary to resort not only to the work of epidemiologists but also to that of mathematicians and statisticians. The present study is an application of two main methods of multivariate analysis -- factorial analysis and canonical correlation analysis -- to the determination of the evolution of the risk to develop coronary heart disease in an urban population.

Coronary Disease↗

Cyto-nucleo-nucleolar variables estimating the lymphocyte reactivity in chronic internal diseases with immune component.

To estimate the degree of lymphocyte reactivity, 11 cyto-nucleo-nucleolar variables were determined in the lymphocyte population from 30 healthy blood donors and 103 patients with chronic internal diseases with immune component such as: rheumatoid arthritis, chronic hepatitis, Hodgkin's disease or chronic lymphocytic leukemia. The data obtained showed that all the cyto-nucleo-nucleolar variables investigated were different in chronic hepatitis from all the other groups, both as regards the relative and absolute areas (low for the cell and nucleus and high for the nucleoli), and as regards the ratios of cell/nucleus and nucleus/nucleolus areas.

Arthritis, Rheumatoid↗

[Benzimidazole derivatives with antihypertensive and platelet antiaggregant actions].

The changing of the chemical structure of 2-benzylbenzimidazole, the active substance of Dibazol (Tromesedan), generated five analogous structures. Two salts of the same active substance have been synthesized in view of improving some of the pharmacological and toxicological features. The results of the anti-AHT and platelet aggregation actions are also presented.

Animals↗

Comparison of risks in cardiovascular diseases.

The paper presents the estimations of the short-time and the long-time (10 years) risks of developing a cardiovascular disease (CD). The standard risk factors considered were: age, deviation from the ideal weight, number of cigarettes smoked per day, level of serum cholesterol and systolic blood pressure. The cardiovascular diseases likely to be induced by these risk factors were: myocardial infarction, angina pectoris, ischemic heart diseases and stroke. The comparison of the estimated probabilities of developing the disease for various risk factors profiles emphasizes the value of epidemiologic intervention already in young agers.

Adult↗