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Biomedical subjects

G Russo

Publications and source records attributed to G Russo.

At least 289 records · Page 16Linked to original sources
PubMed1987

First microbiological approach to dactimicin, a novel aminoglycoside antibiotic.

Dactimicin (ST 900) is the first aminoglycoside antibiotic of Dactylosporangium origin. This drug shows resistance to many enzymes that destroy aminoglycosides. In this first approach, the authors have pointed out the activity of dactimicin against Gram-negative rods, particularly Klebsiella, Enterobacter, Serratia and Gram-positive bacteria, especially methicillin susceptible and resistant staphylococci. Dactimicin showed remarkable antibacterial activity against all strains tested; however this activity was strongly influenced by the inoculum size. The bactericidal activity of dactimicin towards some Gram-positive and Gram-negative bacteria was also evaluated.

Aminoglycosides↗
PubMed1987

In vitro study of dactimicin (ST 900) against methicillin-susceptible and -resistant staphylococci.

The current knowledge on the antimicrobial activity of dactimicin is poor and limited to the study of its activity against gram-negative bacilli. The new acquisition about the use of aminoglycoside antibiotics in infections due to Staphylococci, induced us to evaluate the behavior of this drug against methicillin-susceptible and -resistant Staphylococci, in comparison with fortimicin A and amikacin. Dactimicin (ST 900) shows good antibacterial activity and a strong bactericidal effect at MIC concentrations in all strains tested.

Amikacin↗
PubMed1987

Suprascapular neuropathy in volleyball players.

We examined ninety-six top-level volleyball players from eight teams that competed during the 1985 European Championships, and twelve players were found to have asymptomatic isolated paralysis of the infraspinatus of the dominant side. Three players were studied with electromyography and Cybex-II isokinetic dynamometry. The results revealed denervation of the infraspinatus and approximately a 22 per cent loss of strength of the affected arm during external rotation. These findings were attributed to repeated stress due to stretching of the nerve during cocking of the arm and follow-through when the athlete was serving.

Adult↗
PubMed1986

[Effect of antibiotic chemotherapy on urinary N-acetyl-B-D-glucosaminidase activity in patients with chronic pyelonephritis].

The behaviour of N-acetyl-B-D-Glucosaminidase (NAG) was studied in the urine of patients with chronic pyelonephritis under pharmacological treatment for renewed attacks of acute renal inflammation. It was noted that by the end of target chemo-antibiotic treatment all patients presented a reduction in the inflammation and hence the tubular distress. Once treatment was suspended several patients showed an increase tendency in the activity of the enzyme followed by the reappearance of significant bacteriuria and/or leukocyturia. The acute attack of renal inflammation would not have been recognised if the enzymuria technique had been used to monitor the patients.

Acetylglucosaminidase↗
PubMed1986

[Behavior of certain forms of enzymuria in subjects treated with pipemidic acid].

Three groups of subjects (I with infections of the lower urinary ways; II with chronic pyelonephritis; III healthy controls) were treated with pipemidic acid for 10 consecutive days and the behaviour of their urinary NAG and AAP was studied. It was discovered that the healthy group and the patients with infections of the lower urinary ways showed no significant variations in the urinary activity of the two enzymes following the administration of pipemidic acid. However there was a distinct reduction in both enzymes in patients with chronic pyelonephritis who presented demonstrable bacterial sensitivity to the drug. Apart from the fact that it produces no nephrotoxic effects at least in the doses used and for the treatment period adopted, the drug is therefore considered to reduce renal inflammation that is beneficial to individuals with chronic interstitial nephropathy.

Acetylglucosaminidase↗
PubMed1986

Phenotypically immature IgG-bearing B cells in patients with hypogammaglobulinemia.

We investigated the prevalence of phenotypically immature IgG B cells (i.e., coexpressing surface IgG and IgM) in the peripheral blood of 12 patients with hypogammaglobulinemia and in normal individuals. Patients had ataxia-telangiectasia (N = 1), hyper-IgM combined immunodeficiency (N = 1), or common variable immunodeficiency (CVI). IgG/IgM-positive B cells were evaluated by two-color immunofluorescence using fluorescein- or rhodamine-conjugated goat antiserum; to minimize artifacts due to in vivo cytophilic binding of autologous IgG, cell-bound cytophilic Ig were eluted at pH 4 and Fc receptors were blocked by heat-aggregated rabbit IgG before fluorescent staining. All patients, except two with late-onset CVI, had markedly increased proportions of double-stained IgG B cells (56 to 100% of IgG-bearing B cells) in comparison with normal individuals (11 to 33%).

Adult↗
PubMed1986

Hypogammaglobulinemia with hyper-IgM, severe T-cell defect, and abnormal recirculation of OKT4 lymphocytes in a girl with chronic lymphadenopathy.

We describe here one 8-year-old girl with an unusual form of immunodeficiency, characterized by hypogammaglobulinemia with hyper-IgM, severe T-cell defect, and chronic lymphadenopathy. Patient's B cells failed to produce IgG or IgA in vitro following stimulation with either pokeweed mitogen or Epstein-Barr virus, suggesting an intrinsic B-cell defect. Abnormal T-cell function was demonstrated by impaired in vivo delayed type hypersensitivity, reduction of mitogen-induced proliferation and interleukin 2 production, reduction of interferon-gamma production, and marked decrease of circulating OKT4+ cells. The latter cells were found in normal proportion in the patient's lymph node tissue. This finding suggests that the decrease of OKT4+ cells in peripheral blood was due to the abnormal recirculation of these cells. The identity of this syndrome with the infantile form of the acquired immunodeficiency syndrome was apparently ruled out by the failure to demonstrate HTLV-III-related sequences in patient's lymphocytes or virus-specific serum antibodies.

Agammaglobulinemia↗
PubMed1986

Population structure of eastern Sicily.

A sample of 465 persons from Eastern Sicily was studied for 11 red-cell enzymes, namely GLO, GPT, EsD, PGP, PGD, Dia, AcP, PGM, SOD, CAI and CAII. The allele frequencies were compared with those of other Italian populations and showed that the island is homogeneous with the mainland for these systems. The rate of heterozygosity was studied as a function of interparental distance; although high (0.77) the correlation did not reach significance.

Acid Phosphatase↗
PubMed1986

Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition.

Human embryonic development involves transition from yolk sac (YS) to liver (L) hemopoiesis. We report the identification of pluripotent, erythroid, and granulo-macrophage progenitors in YS, L, and blood from human embryos. Furthermore, comprehensive studies are presented on the number of hemopoietic progenitors and precursors, as well as of other cell types, in YS, L, and blood at precisely sequential stages in embryos and early fetuses (i.e., at 4.5-8 wk and 9-10 wk postconception, respectively). Our results provide circumstantial support to a monoclonal hypothesis for human embryonic hemopoiesis, based on migration of stem and early progenitor cells from a generation site (YS) to a colonization site (L) via circulating blood. The YS----L transition is associated with development of the differentiation program in proliferating stem cells: their erythroid progeny shows, therefore, parallel switches of multiple parameters, e.g., morphology (megaloblasts----macrocytes) and globin expression (zeta----alpha, epsilon----gamma).

Colony-Forming Units Assay↗
PubMed1986

New trends in the chemotherapy of staphylococcal infections.

The authors evaluated the susceptibility of some antibiotics against several Staphylococci subdivided in lyogroups and different resistance patterns: methicillin-susceptible/penicillin-susceptible (MS/PS), methicillin-susceptible/penicillin-resistant (MS/PR), methicillin-resistant/penicillin-resistant (MR/PR) and methicillin-resistant/penicillin-susceptible (MR/PS). The antimicrobial agents used were: methicillin, penicillin, rifampin, tetracycline, lincomycin, erythromycin, gentamicin and netilmicin. Netilmicin showed better activity against all Staphylococcus strains tested, particularly against coagulase-negative.

Anti-Bacterial Agents↗
PubMed1986

Epidemiology of resistance to netilmicin and other aminoglycosides.

The authors carried out a study to evaluate the epidemiology and resistance of netilmicin, gentamicin, tobramycin and amikacin during the 1984-1985 period. Clinical specimens of different origin, drawn both from hospitalized and outpatients were used in the study. The strains were tested for their sensitivity to aminoglycosides. In particular the degree of resistance in both fermentative and non-fermentative gram-negative strains was determined. As previously pointed out in other works, netilmicin showed good antimicrobial activity in respect to other aminoglycosides.

Amikacin↗