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Biomedical subjects

G Rosenhamer

Publications and source records attributed to G Rosenhamer.

At least 37 records · Page 2Linked to original sources
PubMed1975

Cardiovascular responses to changes in carotid sinus transmural pressure in man.

To study the relative importance of cardiac and peripheral effector mechanisms in the carotid sinus baro-reflex in man cardiovascular responses to equal changes of the carotid sinus transmural pressure (Ptm) in either direction of the normal were recorded and compared in eight physically well-trained young male volunteers. In both the supine and the 70 degrees head-up position, a decrease in Ptm produced a more potent reflex response of the systemic arterial pressure than did a similar increase in Ptm. Whereas the arterial pressure response to increased Ptm was due solely to a reduction in vascular resistance, a significant increase in cardiac output contributed to the more potent pressor response to a decrease in Ptm and thus to the predominantly antihypotensive properties that characterize the carotid sinus baroreceptor control system in man. However, since combined beta-adrenergic and parasympathetic blockade abolished the effect of reduced Ptm on cardiac output without greatly impairing the blood pressure response, it is concluded that adjustments in cardiac output are not of critical importance in the buffering function of the carotid sinus baroreceptors. Autonomic cardiac blockade exaggerated the fall in cardiac output on head-up tilt, the arterial pressure remaining unaffected due to a compensatory increase in systemic vascular resistance.

Adrenergic beta-Antagonists↗
PubMed1975

Effect of quinidine on maintaining sinus rhythm after conversion of atrial fibrillation or flutter. A multicentre study from Stockholm.

In a controlled study comprising 176 patients, quinidine in the form of Kinidin Durules was found to reduced significantly the recurrence of the atrial fibrillation during a 1-year follow-up period after successful electric shock conversion. After one year, 51 per cent (52/101) of the patients in the quinidine group, and 28 per cent (21/75) in the control group remained in sinus rhythm (P smaller than 0.001). No less than 43 per cent of the patients converted to sinus rhythm during treatment with maintenance doses of quinidine sulphate before intended DC conversion. Gastrointestinal side-effects were not uncommon, and caused interruption of quinidine treatment in some cases.

Adult↗
PubMed1974

Gravitational stress and exercise.

This paper deals with the influence of G forces on certain circulatory and metabolic adjustments to dynamic exercise. Leg exercise in the sitting position increases systemic mean pressure both at normal and at increased G, thus improving G tolerance. When the force of gravity is increased to three times its normal value, leg exercise produces a much more marked increment in stroke volume than in heart rate, which contrasts with the case at normal gravity. Beta-adrenergic blockade, which strongly inhibits the heart rate response to gravitational stress, but leaves the systemic mean pressure and G tolerance unaffected, exaggerates the dominance of the stroke volume increase in exercise at increased G. With leg exercise at increasing work loads at 3G, the O2 uptake tends to level off and the arterial lactates to rise at a lower load than at normal gravity, indicating that the upper limit for the O2 uptake is lowered by the G force. A progressive increase of the venous admixture in the lungs suggests that the primary limitation of the O2 transport occurs in the pulmonary gas exchange.

Adrenergic beta-Antagonists↗