Search PubMed⌕ Search

Biomedical subjects

G Rosen

Publications and source records attributed to G Rosen.

At least 127 records · Page 7Linked to original sources
PubMed1986

Acute bilateral total deafness complicating mumps.

While it is well known that mumps is a potential cause of deafness, it is not generally appreciated that it can produce total deafness. The damage is usually unilateral but bilateral disease has been recorded. A case is presented of severe bilateral hearing loss during a mumps epidemic in which, in spite of intensive conventional as well as lesser known therapy, no improvement occurred. In the absence of a successful therapeutic regime it is clearly advisable to intensify immunization in non-developed countries.

Child↗
PubMed1986

Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects.

Auditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL clicks presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups. IPLD(I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the peripheral portion of the auditory system with axonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.

Adolescent↗
PubMed1986

Transient cerebral dysfunction secondary to high-dose methotrexate.

A transient acute neurologic syndrome occurred in 22 patients receiving high-dose methotrexate (HDMTX) (8 to 9 g/m2) for a variety of malignancies. The neurologic signs were similar in all cases. The syndrome occurred an average of six days after the second or third weekly treatment. Common findings included behavioral abnormalities, focal sensorimotor signs, and abnormal reflexes. Signs often alternated from one side to the other. Evaluations including computed tomography (CT) scan, lumbar puncture, hemogram, and blood chemistry were normal. The EEG revealed some slowing in all cases. The cause of this syndrome is unknown. It is transient and usually does not recur. Its appearance does not preclude further treatment with HDMTX.

Adolescent↗
PubMed1986

Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.

Since the inception of adjuvant chemotherapy for osteogenic sarcoma (OS), 25 patients were treated for telangiectatic osteogenic sarcoma (TOS) from 1973 through 1980. This represented 12% of all patients with primary OS of an extremity seen during this time period. Tumors that demonstrated only focal areas of TOS with areas of other subtypes were designated not as TOS but as "mixed" subtypes of OS. In the 25 patients with pure TOS, surgery included 18 amputations and seven resections for the primary tumor. Ten patients were treated on the first chemotherapy protocol (T-4) including high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR), Adriamycin (ADR), and cyclophosphamide (CYC). Of those 10 patients, five have been free of disease for seven to ten years from the time of diagnosis. Nine patients were treated on the second protocol (T-7) including HDMTX with CFR, ADR, and the combination bleomycin, cyclophosphamide, and dactinomycin (BCD). Six of those nine patients are disease-free survivors 63 to 88 months (median, 63 months) from diagnosis. Six were treated on the third chemotherapy protocol (T-10) including HDMTX with CFR, ADR, BCD, and the substitution of cisplatinum for those not having a complete response to preoperative chemotherapy with HDMTX. All six of the latter are disease-free survivors 42 to 56 months (median, 49 months) from the start of treatment. Toxicity included two HDMTX-related drug deaths in patients started on treatment prior to 1977. Of the entire group, 17/25 (68%) have remained free of disease at a mean follow-up time of over five and one-half years. This study demonstrates that TOS is responsive to chemotherapy and is potentially curable. Some prior reports of the uniformly poor prognosis of this variant of OS should not discourage attempts of curative therapy by chemotherapy and surgery.

Adolescent↗
PubMed1985

Effect of intensive adjuvant chemotherapy on wound healing in 69 patients with osteogenic sarcomas of the lower extremities.

Reported surgical adjuvant trials in humans have resulted in little clinically significant impairment of wound healing. Such trials are often carried out with subtherapeutic doses or with the drugs administered relatively late in the wound healing process. It is the objective of our study to investigate the effect of intensive pre- and postoperative chemotherapy (BCD, ADR, HD-MTX) on wound healing in patients with osteogenic sarcomas. Wound healing was defined in our study as lack of infection. In a series of 110 patients with osteogenic sarcomas we analyzed the data of 69 patients with lower extremity lesions: of these, 54 patients had distal femur lesions and 15 had upper tibia and fibula lesions. All the patients underwent en-bloc resections and insertion of a prosthetic device. Pre- and postoperative antibiotics were given routinely. In 80% of our patients (55/69) an uneventful postoperative course was recorded with respect to wound healing. None of these required a secondary operative procedure. Débridement of the wound or débridement of the wound followed by skin grafting had to be performed in 14% (10/69) of the patients. Most of the amputations were performed early in this series of cases. After secondary surgery wound healing was uneventful in most of the patients. No patient died as a consequence of wound infection. Mixed bacterial infections were found in 13/14 patients. No single specific bacterium could be identified. One patient developed a fungal infection (aspergillosis). Eight infections were secondary to skin necrosis. In this series we later found the serious effects of the skin necrosis and slough could be reduced by early intervention with a muscle pedicle flap.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1985

Unusual extraosseous tumoral accumulation of 99mTc-MDP.

Three cases (rhabdomyosarcoma, lymphoma, and metastatic malignant melanoma) of unexpected increased uptake of methylenediphosphonate labelled by technetium 99m sodium pertechnetate (99mTc-MDP) are described. The possible mechanisms of the extraosseous tumoral accumulation of 99mTc-MDP in these malignancies are discussed. The usefulness of this method for the diagnosis, localization, and follow-up of some extraosseous tumors is evaluated.

Adult↗
PubMed1985

Symptoms and lung function in low-exposure to TDI by polyurethane foam manufacturing.

A cross-sectional investigation was performed in seven polyurethane foam manufacturing factories. Lung function tests were performed at the factories by spirometric and nitrogen wash-out methods. Sixty-seven persons were investigated before and after the work shift, and exposure to toluene diisocyanate (TDI) was evaluated by subject-carried sampling equipment on the same day. The day mean exposure to TDI was 0.008 mg/m3 (0.001 ppm). In the non-smokers there was an increased frequency of symptoms from the airways reported in the exposed subjects as compared to the unexposed controls. There were, however, no signs of acute or chronic effects on the lung function measured by spirometric and nitrogen wash-out methods, which could not be explained by smoking.

Adult↗
PubMed1985

The radionuclide diagnosis, evaluation and follow-up of malignant external otitis (MEO). The value of immediate blood pool scanning.

A patient suffering from malignant external otitis (MEO) underwent early blood pool scanning followed after 2 hours by 99m Tc MDP bone scanning and serial Ga-67 citrate scintigraphies of the skull. The former two procedures served as a diagnostic tool to MEO. The latter was used for estimating the extent of the infective process and for following-up the efficacy of treatment. The complementary role of these three procedures in the diagnosis and follow-up of MEO, with special emphasis on immediate blood pool scanning as part of the diagnostic procedure, is illustrated.

Aged↗
PubMed1985

Combined-modality treatment of osteogenic sarcoma of the skull.

The authors present the results of combined-modality treatment in eight patients with osteosarcoma of the skull. Six patients had de novo tumors, and two others had secondary sarcomas resulting from malignant transformation in Paget's disease. Wide surgical excision and combination chemotherapy were used in seven patients, and surgery and radiation therapy were employed in one case. Following chemotherapy, six patients underwent additional surgery. This aggressive approach resulted in four long-term survivors among the patients with de novo tumors. These data suggest that surgery in combination with chemotherapy provides the best potential for long-term disease control in patients with osteosarcoma of the skull.

Adolescent↗