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Biomedical subjects

G Rognoni

Publications and source records attributed to G Rognoni.

47 records · Page 3Linked to original sources
PubMed1977

[Hyperglycemia in acute myocardial infarction (author's transl)].

50 non-diabetic patients, less then 70 y.o. and with fasting blood sugar (FBS) subsequently proved to be normal, consecutively admitted to the Coronary Care Unit by the 10th hour of acute myocardial infarction (AMI), have been studied. Blood sugar (BS) and white blood cell count (WBC) on admission and serum CPK every four hour until the 36th hour, have been determined. Oral glucose tolerance test (OGTT) has been performed at least one week later, when FBS has been determined. In 16 patients with normal OGTT the test has been repeated twice, 4 to 15 months later, before and after a cortisone load. Data have been statistically computed. Mean blood sugar on admission was significantly higher then mean FBS. No correlation was found between BS and WBC neither between BS and maximal CPK. No significant difference has been found between the mean BS on admission among 25 patients with normal OGTT and the one among the remaining 25 patients with abnormal OGTT. The OGTT was confirmed to be normal in the 16 patients belonging to the former group, who had the test repeated, with a single exception as far as the cortisone-OGTT is concerned. The above results are consistent with the opinion that the hyperglycemia usually observed during the first hours of AMI, is related to the acute medical stress and in no way indicates subclinical and/or latent diabetes.

Acute Disease↗
PubMed1976

[Correlations between plasmatic concentrations and antiarrhythmic effect of bunaphtine (author's transl)].

Antiarrhythmic effect of Bunaphtine (1.5 mg/kg) (e.v. in 2 min) was studied in 35 patients with ectopic rhythms, both ventricular and supraventricular. Arrhythmia was checked by continuous electrocardiographic recording. Bunaphtinemia was determined by spectrophotometric method. Plasma concentration levels proved that Bunaphtine is cleared from the blood in two different stages: T1/2alpha = 0.5 min and T1/2beta = 84.7 min. Antiarrhythmic effect was observed in connection with the fast distribution phase and it was even more evident when plasma concentration fluctuated around 3-4 mg/l. Extrasystoles increased when Bunaphtine levels diminished. The minimum effective level showed fairly good individual differences. In three cases with congestive heart failure, hepatic and renal insufficiency the increase or the appearance of ventricular extrasystole was related to high Bunaphtinemia levels. Risk of toxicity seems to be related to the dose and the administration methods. Cardiac decompensation or hepatic and renal insufficiency determine more elevated and protracted Bunaphtinemia levels.

Adolescent↗
PubMed1976

[Blood bunaphthine during dynamic physical exercise and anti-arrhythmic action].

The course of bunaphtinemia during submaximal exercise was studied. To 5 patients showing the appearance or the increase of extrasystole, both ventricular and supraventricular, during ergometric test on the bicycle ergometer, bunaphtine was administered by the following method: a first dose of 0.5 mg/kg was injected endovenously in 2 minutes followed by a constant endovenous infusion at the speed of 2.5 mg/min, throughout the exercise. Doses were calculated referring to a pharmacocynetic pattern with two compartments and supposing an apparent distribution volume of 3 l/k. Resulting bunaphtinemia curves showed a steady state and were completely above the minimum effective standard throughout the test. In all patients the drug prevented ventricular arrhythmias and compared to the standard reduced the supraventricular arrhythmias by 80%.

Aged↗