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Biomedical subjects

G Roberts

Publications and source records attributed to G Roberts.

At least 199 records · Page 11Linked to original sources
PubMed1976

Flavobacterium meningosepticum in the hospital environment.

Ten strains of Flavobacterium meningosepticum were isolated from routine clinical material during a period of two years. Of a number of antibiotics tested, clindamycin was the only one to which they were fully sensitive. The organism was found in chlorhexidine gluconate (Hibitane) solutions in use on the wards for the storage of thermometers and for routine disinfection.

Adolescent↗
PubMed1976

Radioimmunoassay of calcitonin in plasma, normal thyroid, and medullary thyroid carcinoma of the rat.

We have developed a sensitive immunoassay for murine calcitonin which can measure the basal concentration of the hormone in peripheral plasma of rats as well as the calcitonin, extracted from rat thyroid tissue. Human calcitonin was used for tracer, standard, and antibody production. Assay methods were devised to minimize artifacts which have been shown to spuriously influence immunoassay performance. The basal plasma concentration of calcitonin in rats was 6 to 75 pg. per milliliter. Infusions of calcium, pentagastrin, and PGE2 produced a 2- to 7-fold increase in plasma calcitonin. Elevated concentrations of calcitonin were demonstrated in tumor specimens obtained from the second and fourth generations of a transplanted rat medullary thyroid carcinoma. Our results demonstrate that calcitonin circulates in the peripheral plasma of rats in the basal state and that hormone concentrations change during functional tests of secretion. This assay will permit studies of calcitonin secretion in physiological and pathophysiological states in the rat.

Animals↗
PubMed1975

Oestrogen-induced endometrial carcinoma in a patient with gonadal dysgenesis.

This case report describes the genesis of endometrial carcinoma after prolonged stilboestrol therapy in a patient with gonadal dysgenesis (Turner's syndrome). The varied histological appearance included the presence of cartilage-like material. A review of the literature reveals the need to treat these patients with combined oestrogen/progestogen preparations rather than with continuous unopposed oestrogens.

Adenocarcinoma↗
PubMed1973

A year in post.

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Hospital Administration↗
PubMed1972

Therapeutic abortion by intra-amniotic injection of prostaglandins.

Intra-amniotic injection of either prostaglandin F(2)alpha or prostaglandin E(2) was used in an attempt to induce therapeutic abortion in mid-pregnancy in 27 patients. Termination of pregnancy was successful in 11 out of 13 cases when prostaglandin E(2) alone was used, but in only 6 out of 14 cases when prostaglandin F(2)alpha was used. A further eight patients aborted after additional intravenous oxytocin stimulation, but the combined procedures failed altogether in two patients who were initially given prostaglandin F(2)alpha. The technique was simple, free from serious side effects, and reasonably effective when prostaglandin E(2) was used.

Abortion, Therapeutic↗