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Biomedical subjects

G Rizzato

Publications and source records attributed to G Rizzato.

At least 73 records · Page 4Linked to original sources
PubMed1984

Can pulmonary hypertension be predicted by non-invasive approach? Echocardiographic and haemodynamic study.

41 patients suffering from Chronic Obstructive Lung Disease (COLD) and 44 with Sarcoidosis were studied. Said patients underwent respiratory function tests, echocardiography (M.mode) to assess the right ventricular index ( RVI = diameter of the right ventricular cavity corrected by body surface) and the thickness of the right ventricular anterior wall ( RVAWT ); patients also underwent right heart haemodynamics (Swan-Ganz catheter). These data were further statistically studied by means of multiple regression in order to assess the eventuality of a non-invasive prediction of pulmonary artery mean pressure (PAP): variables taken into consideration were: age, body surface (BS), RVI , RVAWT , arterial oxygen pressure (PaO2), arterial carbon dioxide pressure (PaCO2) and PAP dependence according to each case group and the interaction of each group itself on the variables. RVI appeared to be the most reliable, in fact, when PaCO2 is also available, the standard error of estimation (SEE) was only 3.84 mmHg and the coefficient of determination was equal to 85.5% with a notable improvement when compared to results seen in previous studies. This behaviour was observed both in patients with early sarcoidosis and in COLD patients with mild pulmonary hypertension. This might be due to the fact that we took the right ventricle into consideration which inevitably feels the increase in pulmonary hypertension.

Adolescent↗
PubMed1983

Echocardiographic and hemodynamic assessment of right heart impairment in chronic obstructive lung disease.

42 patients with chronic obstructive lung disease underwent right heart hemodynamics (Swan-Ganz catheter) and M mode echocardiography. Echocardiographic study showed that right ventricular index (RVI) and right ventricular anterior wall thickness (RVAWT) were increased in most patients, while septal thickness and motion were nearly always normal. The finding of impaired RVI and normal RVAWT in several patients, while no one showed normal RVI and increased RVAWT, suggests that arterial pulmonary hypertension results in initial dilatation and only later in hypertrophy of the right ventricle. Echocardiographic parameters were well correlated with hemodynamic and pulmonary function parameters. The good correlations between echocardiographic and hemodynamic data suggest that echocardiography may be a useful technique in the noninvasive assessment of the effects of pulmonary hypertension on the right heart in COLD.

Adult↗
PubMed1983

Assessment of sarcoidosis activity by 67gallium lung scan. A study with follow-up.

71 consecutive patients with histologically confirmed sarcoidosis, in various clinical stages of activity, were submitted to 67Ga lung scan, and 23 of them were studied with two or more scans at intervals of 4-6 months. In patients on steroid therapy, the drug was suspended 7 days before scan to avoid the steroids interfering with the gallium (Ga) uptake mechanism. In order to assess the usefulness of 67Ga in the evaluation of sarcoid activity, six other parameters of activity were considered, ranging from angiotensin-converting enzyme levels to progressive symptoms, from deteriorating X-ray or pulmonary function tests to clinical or laboratory evidence of prominent extra thoracic involvement. Our work suggests that Ga scan is more sensitive than chest X-ray in determining the degree and variation of pulmonary sarcoidosis activity, in evaluating the response to therapy, and in foreseeing the relapses. In some cases it gives information not detectable with other noninvasive criteria. The detection of patients with active disease, after discontinuation of steroids 7 days before scan, raises doubts about the opportunities of scanning patients on steroids, and suggests that further studies on this point are needed.

Adolescent↗
PubMed1983

Right heart impairment in sarcoidosis: haemodynamic and echocardiographic study.

62 patients with histologically confirmed sarcoidosis (7 with Stage 0, 9 with Stage I, 20 with Stage II, 26 with Stage III) underwent right heart haemodynamics (Swan Ganz) and M-mode echocardiography. Haemodynamic study showed mild to moderate pulmonary hypertension in many patients with Stage II and III sarcoidosis, and 5 patients with Stage 0 healed sarcoidosis, showed borderline values of right sided pressures. Echocardiographic study showed increased right ventricular index (RVI) and right ventricular anterior wall thickness (RVAWT) in most patients. The good correlations between echocardiographic and haemodynamic data suggest that echocardiography may be a useful technique for the non-invasive assessment of the effects of pulmonary hypertension on the right heart in sarcoidosis.

Adult↗
PubMed1980

Relationship between chronic PaCO2 and total body buffering capacity in patients with chronic obstructive lung disease.

17 subjects were carefully selected among 150 patients with COLD: all patients with one or more conditions or diseases that could alter the physiological response to chronic hypercapnia were eliminated. During a period of 13 to 28 days, the acid-base response to slow carbon dioxide changes was studied in the selected patients. Total body buffering capacity was expressed as dH+a/dPaCO2 and showed to be an inverse function of chronic PaCO2 (defined as the value of PaCO2 in clinical and acid-base steady status for each patient), according to the previous suggestions of Weiss and Dulfano and to the report of Ingram and co-workers during acute carbon dioxide changes in the same patients.

Acid-Base Equilibrium↗
PubMed1980

[The diagnosis of hepatic metastases is a frequent problem in clinical practice (author's transl)].

In 131 verified cases with known primitive tumor, the diagnostic accuracy of the echotomography resulted in 84% (sensitivity 89%; specificity 76%). Technical insufficiency of the echotomography did not define the diagnosis in 8% of the patients. The evidence of solid lesions in both lobes of the liver and the involvement of the inferior vena cava are the criteria for inoperability and selection for angiographic test. The diagnostic value of the echotomography was low in cases where the primitive tumour was not identified because of the non specificity of the echo-structure of the solid intrahepatic lesions. Angiography is essential when a liver resection is planed.

Angiography↗
PubMed1980

[The pulmonary artery hypertension in patients with sarcoidosis (author's transl)].

Svanborg (1961) found normal pulmonary artery mean pressures in eleven patients with stage II sarcoidosis. By contrast Gluskowski et al. (1978) have shown few abnormally high values in the same condition. We have not found published haemodynamic data concerning stage O sarcoidosis. Thus we have performed right haemodynamic study (by Swan-Ganz catheters) on 19 patients with hystologically proven sarcoidosis (8 stage III, 6 stage II, 3 stage I and 2 stage 0). 13 of them underwent also haemodynamic study during exercise (1watt/Kg). Pulmonary artery hypertension (at rest or after exercise) was frequently found in stage III, and less frequently in stage II. In stage I pulmonary artery mean pressure was between 15 and 20 mmHg in three patients (out of three). In one case (out of two) in stage 0 (admitted to hospital owing to exertional dyspnoea) right heart catheterisation showed pulmonary hypertension during exercise in spite of normal pulmonary function tests (including spirometry, DLCO, pulmonary scintigrafic and X-ray pattern also using 3X magnification radiology).

Adult↗
PubMed1976

Regional lung perfusion and pulmonary artery pressure in chronic obstructive lung disease.

In 22 chronic bronchitics with or without emphysema, the authors measured regional pulmonary perfusion in the supine position and calculated the ratios of radio-active tracer (131I-MAA) concentrations in the lung apices and bases (U/L ratio). This ratio was found to be normal in the right lung and tendentially high (though not to a statistically significant degree) in the left lung, this being probably due to the presence of an enlarged heart (13 patients showed evidence of right ventricle hypertrophy and/or overload). The correlation between the U/L ratio and functional impairment of respiration expressed spirometrically failed to reach statistical significance and the same was true of the correlation between the U/L ratio and mean pulmonary arterial pressure at rest.

Adult↗
PubMedDate not supplied

Bone loss in prednisone treated sarcoidosis: a two-year follow-up.

We followed up 35 sarcoid patients treated with prednisone for two years in order to evaluate bone mineral loss over time. Vertebral cancellous mineral content was detected by quantitative computed tomography and calibration phantom before beginning prednisone therapy and monitored two more times at yearly intervals. The percent mineral loss (ML%) averaged -13.9 +/- 2.1 at the end of the first year and -15.3 +/- 2.6 at the end of second year. We conclude first, that the time course of mineral loss in prednisone treated sarcoidosis is similar to that of other diseases such as asthma and rheumatoid arthritis. In a separate group of 10 early postmenopausal females, we observed a greater ML% averaging -21.9 +/- 16.6 and -26.2 +/- 18.5, at the end of the first and second year respectively. Our second conclusion was thus that the synergic effect of postmenopausal status and prednisone therapy results in an ML% far more significant than expected from the two single conditions.

Adult↗