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Biomedical subjects

G Riotton

Publications and source records attributed to G Riotton.

11 recordsLinked to original sources

[Evaluation of screening for uterine cervix cancer: from theory to practice (author's transl)].

In many regions, screening for cervical cancer activities by means of cytology have developed "on faith", without fulfilling sufficient quality criteria (identification--smear taking--staining--reading--nomenclature of ciagnosis--communication with the practitioner). Progress made in cytological diagnosis and better knowledge epidemiological data make, at present, such a situation inacceptable from the point of view of public health expenses, as well as for the population of women concerned. Thorough evaluation of this problem shows that inadequate programmes could be more harmful than useful. It is then indispensable to evaluate the needs, then to create technical structures of good quality, before starting any mass screening campaign.

Adult

[Creation of an intercantonal tumor register].

A population-based Cancer Registry is a permanent system which records all the malignant tumors occurring in a particular geographical area. Its main objective is to set up the basis for the establishment of statistics, either for practical use (cancer control) or for research. More than a hundred such registries exist nowadays throughout the world, and in Switzerland a number have been recently created or are in process of organization (cantons of Geneva, Neuchâtel, Vaud, Zurich, Basel). A coordination group has accordingly been created to harmonize the data and the coding system, in order to allow the organization of an Intercantonal Registry.

Neoplasms

Endometrial cytohistology by aspiration technic and by Gravlee Jet Washer: a comparative study.

An office procedure of intrauterine aspiration yielded a 99% diagnostic accuracy in 100 patients admitted for either curettage or hysterectomy. After correlation with surgical diagnosis, no false-positive or false-negative results were found. The method provides tissue for cell blocks adequate for histologic diagnosis of endometrial adenocarcinoma and its precursors. The major advantage of this technic in comparison with the Gravlee Jet Washer is its low cost. Moreover, in this study, it proved to be less painful, superior for cell block preparation, and yielded more satisfactory specimens. As a screening procedure for asymptomatic patients at risk, this intrauterine aspiration technic holds promise and must be evaluated by further studies.

Adenocarcinoma

[Endometrial cyto-histology by PISTOLET-aspiration technic (author's transl)].

A modified intrauterine aspiration technic for detection of endometrial adenocarcinoma and its precursors has been described. This method which is simple, inexpensive and requires neither anaesthesia nor analgesia, allows cyto-histologic diagnoses of endometrial lesions. A correct cytologic or cyto-histologic diagnosis was made in 93.9% of the 277 cases examined. Of the premalignant and malignant endometrial lesions, the diagnostic accuracy was 100%.

Biopsy, Needle

Cytochemical properties of human endometrial cells in vitro.

The cytochemical properties of the human endometrial cell nuclei have been studied during the menstrual cycle in eight women by means of two different microfluorometric methods, both considered to be specific for DNA: the BAO-Feulgen method and a method based upon an interaction between DNA and mithramycin. An in vitro system was developed where dissociated endometrial cells were studied at 4 hours and 18 hours of incubation at 37 degrees C. The cytochemical properties of the dissociated endometrial cells did not change significantly in the in vitro system used. An increase in the BAO-fluorescence intensity per cell nucleus was observed in all the endometrial samples when compared with the diploid standard DNA value of a non-growing cell population. A similar increase in the mithramycin fluorescence intensity per cell nucleus appeared only during the secretory phase. It is suggested that the nucleoproteins play an essential role in changing the cytochemical properties of the human endometrial cell nuclei during the menstrual cycle.

Analysis of Variance