Search PubMed⌕ Search

Biomedical subjects

G Renner

Publications and source records attributed to G Renner.

At least 37 records · Page 2Linked to original sources
PubMed1987

Effects of pentachlorophenol and some of its known and possible metabolites on different species of bacteria.

The antibacterial activity of pentachlorophenol and 35 of its known or possible metabolites against 30 different species of bacteria was tested. In comparison with pentachlorophenol, no increase of inhibitory activity was found for any of the chlorinated anisoles tested (except for pentachloroanisole against Streptomyces spp.), 2-chlorophenol, 2,6-dichlorophenol, 2,3,6- and 2,4,6-trichlorophenol, 2,3,5,6-tetrachlorophenol, tetrachloro-1,4- and -1,3-benzenediol (except for the 1,3-isomer against Streptomyces spp.), tetrachloro-1,3-dimethoxybenzene, and tetrachloro-1,3-benzenediol diacetate. Two chlorophenols, five dichlorophenols, four trichlorophenols, two tetrachlorophenols, and tetrachloro-1,2-benzenediol were more active than pentachlorophenol against some, but not all, of the strains tested.

Bacteria↗
PubMed1987

Secondary and metastatic tumors of the orbit.

We have presented three cases of metastatic tumor to the orbit. The first case illustrated metastatic tumor that originated from a cutaneous basosquamous cell carcinoma. This lesion, first reported by MacCormac as being morphologically intermediate between basal and squamous cell carcinoma, has become a topic of some controversy. Conley reported these tumors to represent 1% of basal cell carcinomas. Several authors have reported a higher incidence of recurrence with these lesions, as compared with the ordinary basal cell tumors. Recurrence of basal cell carcinomas are reported as approximately 10%, but are four times greater in the basosquamous cell tumors. The incidence of metastasis with the basosquamous cell tumors has been reported in between 37% and 51% of cases. The second case represented involvement of the orbit by direct extension of a facial squamous cell carcinoma. As illustrated by this case, these tumors can be very aggressive and should be treated with respect. The third case showed the metastatic potential of the nephroblastoma with metastatic tumor that involved the eye, orbit, and maxilla. Diagnostic techniques available in evaluation of these tumors include CT scan, magnetic resonance (MR) imaging, ultrasound, open biopsy, and fine-needle aspiration. Li et al., in an article that compared MR imaging, CT scan, and ultrasound concluded that MR imaging, with the use of the 0.15 T resistive magnet, offered no distinct advantage over the combination of CT and ultrasound in evaluation of patients with orbital tumors.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Nasal spine suspension for reduction and immobilization of mandibular fractures.

Successful treatment of mandibular fractures involves proper fracture reduction and immobilization for an adequate length of time. A simple wire fixation technique that can be used in many situations involves suspension wiring from the base of the anterior nasal spine to a pair of circummandibular wires. The technique may be used alone or adjunctively with other methods of fixation. It offers several advantages over other methods, particularly in the treatment of pediatric mandibular fractures.

Bone Wires↗
PubMed1987

Disorders of smell and taste.

This article describes the anatomy and physiology of the gustatory and olfactory organs in man. Dysfunction of these senses is closely examined with respect to etiology, diagnosis, and treatment. Taste and smell are closely interrelated. An influence on the function of one sense often affects the function of the other sense.

Humans↗
PubMed1986

Effects of pentachlorophenol and some of its known and possible metabolites on fungi.

The fungicidal activity of pentachlorophenol and its derivatives against 16 species of fungi representing 14 genera was tested. In relation to pentachlorophenol, no increase in fungistatic activity was found for pentachloroanisole, pentachloronitrobenzene, hexachlorobenzene, pentachlorophenyl acetate, o- and p-chloranil, the three isomeric chlorophenols, 2,6-dichlorophenol, the three isomeric tetrachlorobenzenediols, the three isomeric tetrachlorodimethoxybenzenes, the three isomeric tetrachlorobenzenediol diacetates, and all of the isomeric mono-, di-, tri-, and tetrachloroanisoles, except for 2,3,5-trichloroanisole with Geotrichum candidadum PC 67 and for 2,3,5,6-tetrachloroanisole with Mucor circinelloides PC 1. Increasing fungistatic activities were seen with 3,5-dichlorophenol, four trichlorophenols, and 2,3,4,5-tetrachlorophenol for all of the strains, with four dichlorophenols, 2,4,6-trichlorophenol, and two tetrachlorophenols for some strains, and with 2,3,6-trichlorophenol for only one strain (M. circinelloides PC 1).

Chlorophenols↗
PubMed1985

Deep neck abscess after tracheoesophageal puncture and insertion of a voice button prosthesis.

A deep neck abscess and cervical osteomyelitis developed in a 37-year-old laryngectomy patient 6 weeks after TE puncture and insertion of a voice button prosthesis. This complication resulted in voice prosthesis failure, multiple surgical procedures, 83 days of hospitalization while receiving parenteral antibiotics, and exposure to potentially fatal complications. Some factors contributing to this problem may include an improperly fitting prosthesis, rough insertion of the prosthesis, and altered tissue response to infection from radiation therapy and surgery.

Abscess↗
PubMed1984

Biotransformation of derivatives of the fungicides pentachloronitrobenzene and hexachlorobenzene in mammals.

Biotransformation of N-acetyl-S-(2,3,5,6-tetrachlorophenyl)cysteine and N-acetyl-S-(pentachlorophenyl)cysteine-S-oxide, of the metabolites of both PCNB and HCB, namely N-acetyl-S-(pentachlorophenyl)cysteine, pentachlorothiophenol, pentachlorothioanisole, 4-methylthio-tetrachlorothiophenol and tetrachloro-1,4-bis(methylthio)benzene, and of the PCNB metabolites, S,S'-(tetrachloro-p-phenylene)dicysteine, and the isomeric tetrachlorothiophenols, has been studied in rabbits, rats and mice, as well as in vitro. Biotransformation products such as thiophenols, thioanisoles, chlorinated benzenes, phenols and anisoles have been identified by g.l.c.

Animals↗
PubMed1984

Mechanisms of the reductive denitration of pentachloronitrobenzene (PCNB) and the reductive dechlorination of hexachlorobenzene (HCB).

The reductive denitration of PCNB and the reductive dechlorination of HCB are complex, and begin with reaction of both fungicides with glutathione, with elimination of the nitro group and/or of chlorine, respectively. The glutathione conjugates are further metabolized by cleavage of the glycine and glutamate residues to give cysteine conjugates or N-acetylcysteine conjugates by acetylation in mammals. The cysteine derivatives are further metabolized by cleavage of the C-S bond to produce thiophenols, which after reductive desulphuration form pentachlorobenzene, or minor chlorinated benzenes, respectively.

Animals↗
PubMed1984

Temporalis pericranial muscle flap for reconstruction of the lateral face and head.

Large ablative surgical tissue defects of the lateral face and head can pose a difficult task for the reconstructive surgeon who must choose from among a large variety of possible reparative techniques. In many situations the temporalis pericranial muscle flap offers the outstanding feature of providing a large amount of soft tissue at no direct expense of donor site skin cover. It is easily obtained and results in negligible functional loss. With care taken to preserve the neurovascular pedicle, this flap may be rotated in multiple directions and even overturned as either surface can receive surface skin closure. The amount of operative time and effort required is much less than for many of the more elaborate reconstructive flaps. Five representative cases are presented.

Adult↗
PubMed1983

Formation of pentachlorothioanisole from N-acetyl-S-(pentachlorophenyl) cysteine in blood and liver of rats "in vivo".

Studies on the biotransformation of N-acetyl-S-(pentachlorophenyl) cysteine, a mutual polar metabolite of the lipophilic fungicides pentachloronitrobenzene and hexachlorobenzene, showed metabolic conversions in rats. The rate of its metabolism, leading in return to more lipophilic and toxic products (1) was investigated by determination of pentachlorothioanisole, its major metabolite in blood and liver of rats. The metabolic rate was found to be very small.

Acetylcysteine↗
PubMed1983

Effects of pentachloronitrobenzene and some of its known and possible metabolites on fungi.

Fungicidal activities of pentachloronitrobenzene and derivatives were tested with Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporon canis. In relation to pentachloronitrobenzene, no increasing fungistatic activities were found with cysteine derivatives. Rising fungistatic activities were seen with pentachlorophenylmethylsulfone and, in some of the strains, with pentachloronitrosobenzene, pentachlorothiophenol, pentachlorophenol, pentachloroaniline, pentachlorophenylmethylsulfoxide, the isomeric tetrachloronitrobenzenes, tetrachlorothiophenols, tetrachlorophenols, and tetrachloroanilines.

Journal Article↗
PubMed1983

Studies on the oxygen toxicity after administration of chelate-forming agents in mice.

The influence of the chelating agents CaNa2-EDTA, penicillamine, dimercaprol, unithiol, dithiocarb, aurin tricarboxylic acid, salicylic acid, and acetylsalicylic acid on the toxicity of oxygen at elevated tension was studied in mice. With the possible exception of dimercaprol, no increase in toxic effects of oxygen was observed after administering these chelate-forming agents in the doses used.

Animals↗
PubMed1981

Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene.

This overview of the metabolism of the fungicides hexachlorobenzene (HCB) and pentachloronitrobenzene (PCNB) indicates similarities in their pathways of biotransformation. Several metabolites of HCB and PCNB, such as chlorinated benzenes, the mercapturic acid, thiophenols, thioanisoles and phenols are identical. Both Fungicides initially react with glutathione, with elimination or of the chlorine of the nitro group respectively. The conjugate, S-(pentachlorophenyl)glutathione, is further metabolized by cleavage of the glutamate and glycine results and acetylation of the amino group of the cysteinyl moiety, to give the mercapturic acid N-acetyl-S-(pentachlorophenyl)cysteine, a major metabolite of HCB and PCNB in rats and rabbits respectively, which is further metabolized to simpler sulphur-containing products.

Animals↗