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Biomedical subjects

G Renard

Publications and source records attributed to G Renard.

At least 289 records · Page 16Linked to original sources
PubMed1977

[Gorlin-Goltz phakomatosis (author's transl)].

Having had the occasion of observing a new case, the authors have started on a new description of a specific autosomal dominant inheritance disease, description which connects an eye trouble with basal cell nevi, with jaw cysts as well as with malformations of the skeleton and nervous lesions, the tumoral lesions having the essential characteristic of possessing and evolutive potential. The authors explain the reasons which have led them to give to this specific disease the name of Gorlin-Goltz phacomatosis.

Abnormalities, Multiple↗
PubMed1977

[Fuchs' endothelial dystrophy--the appearance of the corneal endothelium under the electron microscope (author's transl)].

Studying the various stages of Fuchs' endothelial dystrophy with transmission and surface electronmicroscopy makes the dystrophic and degenerative changes in the endothelial and Descemet's membrane visible: dystrophic changes by the formation of tuberosities, whose structure is very similar to that Descemet's membrane, and degenerative changes by reduction in the number of endothelial cells through destruction of the intercellular connections and through cell necrosis. The second stage is the reformation of the structure by fibroblastic cells. The dystrophic cells lead to the formation of a fibrillary tissue between the cells and the tuberosity-laden Descemet's membrane, which is different from the primary structure of this tissue. The origin of these cells is unknown.

Corneal Dystrophies, Hereditary↗
PubMed1977

[Relationship between blood zinc level and EEG changes under the influence of hyperpnea in normal subjects].

The red blood cell and serum zinc levels have been determined by atomic absorption spectrophotometry on 27 human subjects in apparent good state of health, tested monthly for five months successively. The subjects who present a decreased frequency of the E.E.G. pattern during hyperventilation, also show a diminished red blood cell Zn level, by comparison with the other subjects. This phenomenon suggests a possible relationship between red blood cell zinc concentration and E.E.G. signs of cortical hyperexcitability. These findings are discussed in the light of the recent literature.

Adolescent↗
PubMed1976

[Electroretinography in nephronophthisis. Role of the Senior-Loken syndrome].

The authors report 20 cases of a syndrome named nephronophtisis and probably the same as the syndrome of medullar cystic disease. In all cases systematic electroretinography is performed. Nine cases show important deterioration of the outline. These cases can be included in the syndrome of Senior-Loken. The pathogenesis and familial character of this disease are discussed. The disturbances that appeared between the ocular and renal lesions suggest that there are probably two genes rather than a single pleiotropic gene.

Adolescent↗
PubMed1976

[Scanning electron microscopy study of experimental chorioretinitis in guinea pigs].

Retinal lesions are described with the scanning electron microscope in the uveo retinitis induced in guinea pigs by immunization with rod outer segments of bovine retina. The two surfaces in contact of the pigment epithelium and the photoreceptors are separated from each other and observed on flat preparations. On the epithelial side, the evolution of the degenerescence of epithelial cells is observed, from the early disappearance of villosities until the total destruction of the cells. Through lacks in the epithelial layer where the choroid appears, inflammatory cells migrate towards the retina. The impairement of the visual cells is characterized by progressive destruction of outer then inner segments, with preservation of the external limiting membrane. In some areas the degenerative process reaches the layer of visual cells nuclei. Macrophages, and local clusters of lymphocytes are seen in contact with the retinal surface.

Animals↗
PubMed1976

[Ciliated cells of corneal endothelium. Functional and morphological aspects compared to cilia of other organs].

The presence of ciliated cells has been demonstrated by scanning and transmission electron microscopy in corneal endothelium. This study has been carried out on human cornea in normal and pathological cases and on rabbit's normal cornea. Another study has been lead on regeneration of endothelium after freeze destruction. The cilia cells described have a normal structure. The cilia has nine peripheral groups of tubules without any tubule in the center. The cilia seem to be more numerous in case of corneal disease and during the regeneration of corneal endothelium. The authors compare the presence of ciliated cells in different tissues. This suggest that the potency to form single cilia is present in almost every kind of tissue but there is no proof of their pathological importance. In the corneal endothelium, as in the kidney, cilia seem to have no function of fluid transportation but the possibility for cilia to be a receptor is discussed.

Animals↗
PubMed1976

[The use of freeze-etching in the ultrastructural study of the cornea].

The freeze-etching and freeze-fracturing techniques allow a good examination of fixed and unfixed tissues by the mean of transmission electron microscope. As compared with usual techniques of fixed and embedded tissues we can observe the ultrastructural characteristics of the rabbit cornea: epithelium, stroma and endothelium. This technique is the best one to give a good view of the intercellular junctions. 1) On the epithelial layers we describe intracytoplasmic bunches of filaments and numerous desmosomes. After freeze-fracturing the desmosomes appeared to be formed of aggregated particles on fractured faces. These particles are possibly the point of attachment of intracytoplasmic tonofibrils.

Animals↗
PubMed1975

[Scanning microscopy aspects of the corneal endothelium in disciform keratitis and graft rejection].

Scanning electron microscopic study of corneal endothelium in two cases of corneal disease. In one case of herpetic keratitis with stromal oedema and anterior uveitis an important cellular reaction is found with different cells forming a retrocorneal membrane. In a case of graft rejection there are two different aspects. On somes places there is an inflammatory reaction with lymphocytes and macrophages. The main surface of the graft is covered with indifferenciated cells whose origine is probably the receiver's endothelium.

Cornea↗
PubMed1975

[20 years later. Or, the long-term outcome of so-called mixed tumors of the lacrimal gland].

A report on two cases of long-term recurrence of mixed tumours of the lacrimal glands. The authors assess the problem of the protracted evolution of these tumours and their possible degeneration, and attempt to distinguish the degeneration which follows multiple recurrences of co-existing mixed carcinomatous tumours. They insist on the necessity in these cases of an initial wide neurosurgical exposure of the orbit, so as to perform the widest excision possible.

Adult↗