Biomedical subjects
Publications and source records attributed to G Read.
Toad poisoning was studied in awake and anesthetized dogs. The intoxication was defined with respect to clinical signs, blood changes, and alterations in electrocardiogram, blood pressure, and respiratory rate. The efficacy of propranolol hydrochloride as an antidote was evaluated.
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1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.
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