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Biomedical subjects

G Rassner

Publications and source records attributed to G Rassner.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Determining the prognosis of spinocellular cancer of the skin and lower lip based on the TNM system and additional parameters].

Using the TNM classification established by the UICC, 427 squamous cell carcinomas of the skin and lower lip were classified as belonging to the T class. Additional histometric, histologic, and clinical tumor parameters were also recorded. Prognostic relevance was checked by comparing the overall data with those for metastatic tumors. The results showed that the overall metastasis rate was low (carcinoma of skin: 3.5%; carcinoma of lower lip: 2.7%; mean follow-up period: 5 years). Moreover, the prognoses based on the tumor diameter classes in the TNM system were not specific. Earlier findings tend to indicate that tumor thickness, depth of infiltration, and grade of malignancy should also be taken into consideration if the prognosis is to be estimated accurately. If the level and tumor thickness are taken into consideration, a large group of tumors (50%) can be separated: these tumors do not metastasize, even though they are at least 2 mm thick, and they do not infiltrate the subcutaneous tissue (no risk group).

Aged↗
PubMed1987

[Treatment of condylomata acuminata with systemically administered recombinant gamma interferon].

29 patients suffering from condylomata acuminata were systemically treated with human gamma-interferon obtained by means of gene technology. The daily dose, subcutaneous applied, amounted to 100 or 200 micrograms. 12 patients were completely cleared by surgical excision and additionally treated with gamma-interferon for 7 days. 3 of them developed recurrences. 17 patients were exclusively treated with gamma-interferon 100 or 200 micrograms daily; they underwent 6 courses of therapy, each lasting 7 days, with interruptions of 3-5 weeks of observation. As a result, 5 patients showed complete remission; 2 patients partially responded. The tolerance of the drug depended on the dose. We did not observe any toxic side effects. Our findings suggest that gamma-interferon subcutaneously given may be effective with genital warts.

Adult↗
PubMed1987

[Chronic systemic toxicity of oral photochemotherapy using 8-methoxypsoralen and UVA].

The purpose of the study conducted was to clarify the question of chronic, systemic toxicity from PUVA therapy. Five groups of patients, classified according to length of treatment were examined with respect to 43 laboratory parameters. The results indicated that PUVA had no chronic toxic influence on the liver, kidneys, bone marrow, metabolism, or immune response.

Blood Chemical Analysis↗
PubMed1986

[Gamma interferon in psoriatic arthritis].

Fifteen patients with confirmed psoriatic arthritis were treated with recombinant interferon-gamma (IFN-gamma) between October 1985 and February 1986. In ten patients a marked relief of joint pain was achieved within 28 days. Daily doses of less than 200 micrograms IFN-gamma did not have any effect on the skin lesions. Tolerance of the drug, given subcutaneously, was dose-dependent, no side-effects occurred with dosages of less than 100 micrograms/d.

Adult↗
PubMed1985

[Laboratory studies of long-term photochemotherapy of psoriasis vulgaris].

The study of 40 laboratory parameters from a total of 40,000 individual samples taken from patients who had been treated by means of systemic PUVA therapy for a period up to three years did not reveal any evidence for negative influences on selected peripheral blood enzymes, substrates, metabolites, proteins, lipid fractions, electrolytes, antistreptolysin titer, rheumatoid factors and coagulation values, or urinalysis values. The changes observed were either statistically insignificant, remained within normal ranges, or could not be classified. Under the conditions described, no evidence for chronic toxic organic manifestations could be found, even after several years of PUVA treatment.

Blood Cells↗
PubMed1984

[Diabetes mellitus and skin diseases].

Diabetes mellitus is defined as an hereditary chronic metabolic disease due to an absolute or relative shortage of insulin. There are various types to be differentiated, among others, (I) the insulin-dependent and mostly juvenile type, and (II) the insulin-independent type, which mainly appears in later life. We discuss three main groups of cutaneous diseases. Infections of the skin and underlying tissue predominantly occur along with an acutely disturbed metabolic situation. The late diabetic syndrome includes macroangiopathy (arteriosclerosis) and microangiopathy (rubeosis, necrobiotic granulomas, diabetic skin spots, epidermolysis bullosa diabetica, gangrene). Owing to failure of sensible, motor, or autonomous fibers, diabetic neuropathy may lead to various symptoms - in the extreme case, to neuropathic malum perforans. The diabetic foot represents a collection of various diabetic complications in both early and late stages.

Bacterial Infections↗
PubMed1984

[Surgical treatment of basaliomas with calculated safety margin and control of the histologic borders. Experiences with 355 tumors].

An integrated concept for the surgical treatment of basal cell carcinoma is presented, which is based on individually calculated safety margins and modified microscopically controlled surgery. The individual calculation of the safety margin assumes there is a relationship between the clinically visible tumor diameter and subclinical infiltration; the calculation of the safety margin therefore is based on the size of the clinically visible portion of the basal cell carcinoma. Detection of subclinical infiltration and exclusion of the possibility of subtotal excision are ensured by routine histological control of the margins of the excised specimen. The surgical treatment of basal cell carcinoma presented in this study is considerably less time-consuming than other forms of microscopically controlled surgery. No recurrences have been observed after radical excision of basal cell carcinomas with this method.

Basal Cell Carcinoma↗
PubMed1984

[Trichoadenoma (Nikolowski). A clinical and histologic case report].

"Trichoadenoma," which was described by Nikolowsky 25 years ago as an organoid follicular hamartoma, is today an independent and internationally recognized entity. On the basis of observations in one of our own cases, the clinical picture of trichoadenoma, its histogenesis and its position in the periodic system of the follicular nevi and tumors are discussed. In general, it deals with an benign growth, as so far no malignant transformation has been described. No decision has been made so far as to whether the trichoadenoma is a benign follicular tumor, a hamartoma or a follicular nevus.

Adenoma↗
PubMed1978

Effects of 8-methoxypsoralen plus 365 nm UVA light on Candida albicans cells. An electron microscopic study.

Candida (C) albicans cells were exposed to 8-Methoxypsoralen (8-MOP) concentrations of 1.0 microgram/ml and 10.0 microgram/ml medium and irradiated with 365 nm light. The amount of energy emitted was 4.8 J/cm2. Two divergent types of cell damage occured concerning yeast cell cytoplasm and cell wall. Two hours after exposure cytoplasmic changes involving mitochondria, which showed irregularities in shape, blurred appearance or loss of mitochondrial cristae and outer membrane were seen. The number of vacuoles was increased. The cytoplasm showed large electron transparent areas, the cytoplasmic membrane disappeared in some areas completely. Nucleus and nuclear envelope usually remained intact in early stages. 24h after exposure conspicuous cell wall alterations were observed in addition to cytoplasmic changes. Newly produced cell wall material formed ball-like protrusions or was adherent sickle-shaped to the cell wall. The investigations strongly suggest that the results found after 8-MOP-UVA treatment of C. albicans cells can not be interpreted in the sense of a general cytotoxic effect. Apparently it takes the form of a combination of events involving regressive and progressive alterations.

Candida albicans↗
PubMed1978

[Diagnosis of candida albicans mycosis in gynaecology by the germ tube test (author's transl)].

Experience with the germ tube test for the diagnosis of candida mycosis in gynaecology and dermatology is reported. Candida albicans forms germ tubes in human serum and other culture media at 37 degrees C within 2 to 3 hours. If the initial culture grows yeast, the germ tube test permits the exact identification of the yeast as candida albicans within three to five hours. The specificity of the test is approximately 99%. Of 3270 samples 934 grew yeast and 742 were candida albicans by the germ tube test. 6 samples with a negative germ tube test were identified as candida albicans by the Chlamydospore test. 125 samples showed a candida species, 45 samples showed a torulopsis species and 16 tests identified a trichosporon species. This test is valuable in the routine office practice of gynaecology because of its simplicity and speed.

Candidiasis, Cutaneous↗
PubMed1978

Effects of 8-methoxypsoralen plus 365 nm UVA light on Candida albicans cells. An electron microscopic study.

Candida (C.) albicans cells were exposed to 8-Methoxypsoralen (8-MOP) concentrations of 1.0 microgram/ml and 10.0 micrograms/ml medium and irradiated with 365 nm light. The amount of energy emitted was 4.8 J/cm2. Two divergent types of cell damage occured concerning yeast cell cytoplasm and cell wall. Two hours after exposure cytoplasmic changes involving mitochondria, which showed irregularities in shape, blurred appearance or loss of mitochondrial cristae and outer membrane were seen. The number of vacuoles was increased. The cytoplasm showed large electron transparent areas, the cytoplasmic membrane disappeared in some areas completely. Nucleus and nuclear envelope usually remained intact in early stages. 24 h after exposure conspicuous cell wall alterations were observed in addition to cytoplasmic changes. Newly produced cell wall material formed ball-like protrusions or was adherent sickle-shaped to the cell wall. The investigations strongly suggest that the results found after 8-MOP-UVA treatment of C. albicans cells can not be interpreted in the sense of a general cytotoxic effect. Apparently it takes the form of a combination of events involving regressive and progressive alterations.

Candida albicans↗