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Biomedical subjects

G R Waller

Publications and source records attributed to G R Waller.

34 records · Page 2Linked to original sources
PubMed1969

Feline attractant, cis,trans-nepetalactone: metabolism in the domestic cat.

cis,trans-Nepetalactone, the biologically active component of catnip, was force-fed to the domestic cat. When the (14)C-labeled compound was fed, 86 to 94 percent of the radioactivity was recovered in the urine, 1 to 2 percent was found in the feces, and 1 to 12 percent was collected as carbon dioxide. The major (50 to 75 percent) metabolite was alpha-nepetalinic acid, which was excreted in the urine together with small amounts of dihydronepetalactone, unchanged cis,-trans-nepetalactone, and several unidentified compounds. No marked physiological or histological eflects were observed when 20 to 80 milligrams of cis, trans-nepetalactone was administered orally. This is the first report on the metabolism of a mammalian attractant.

Animal Feed↗
PubMed1969

Metabolism of the alpha-Pyridone Ring of Ricinine in Ricinus communis L.

Chemically synthesized ricinine-3,5-(14)C was used to study the metabolism of this alkaloid in the plant which produces it, Ricinus communis L. In a time course study, ricinine-3,5-(14)C was administered to a series of castor plants (Ricinus communis L.) and the radioactivity recovered in the ricinine samples showed a decrease with increase in time. It was also observed that the alkaloid was translocated to the seed. The in vivo conversion of ricinine-3,5-(14)C to respiratory (14)CO(2) occurred in both light and dark and indicated that the alpha-pyridone ring of ricinine could be degraded.In a comparison of the ricinine content of the various tissues it was observed that in the yellow leaf only a trace amount of the alkaloid was present. Preliminary results indicated that the yellow leaf can also metabolize ricinine-3,5-(14)C to (14)CO(2).

Journal Article↗