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Biomedical subjects

G R Seward

Publications and source records attributed to G R Seward.

At least 19 recordsLinked to original sources
PubMed1990

The elephant man. Part III.

This is the third paper in a series of three articles on Joseph Merrick, The Elephant Man. Three matters are discussed about which there is uncertainty: the disease which affected his left femoral head, the cause of his deformity and the cause of his death.

Fibrous Dysplasia of Bone↗
PubMed1990

The Elephant Man. Part II.

This is the second in a series of three articles on Joseph Merrick, the Elephant Man. A description of his skeletal deformities is given, including details of the skull and dentition.

Bone and Bones↗
PubMed1990

The Elephant Man. Part I.

Joseph Merrick was one of three children. His mother and younger sister were cripples, but their disease is unknown. Joseph's own swellings began to appear in early childhood and he rapidly became so grotesque, that he eventually sought a living as a freak. After an unhappy continental tour, he was given asylum in The London Hospital at the instigation of Mr Frederick Treves, and stayed there until he died. Books, a play and a film have featured his unique story, but each presented it with varying degrees of artistic license. However, contemporary accounts of his condition survive. Both bony abnormalities and substantial soft tissue masses contributed to his deformity. Features of these considered separately suggest neurofibromatosis as a diagnosis, but because the presentation is more extreme than seen in any other recorded patient, other diagnoses have been entertained. In the following three papers, the evidence which supports this diagnosis is reviewed, together with a consideration of the disease affecting his left hip and the manner of his death. This first article reviews the Elephant Man's life story.

History, 19th Century↗
PubMed1975

A metastasising ameloblastoma associated with renal calculi and hypercalcaemia.

A young male had an assumed dentigerous cyst marsupialized and later a recurrent ameloblastoma resected. Eleven years later he was admitted with renal stones and hypercalcemia and metastases of the ameloblastoma in the left lung were discovered. Death occurred as a result of spinal and hepatic spread of his tumor and thrombosis of the renal veins. Renal calcification was demonstrated. The possible causes of the hypercalcaemia which was not associated with a raised serum parathormone or affected by parathyroidectomy is discussed.

Adolescent↗