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Biomedical subjects

G R Roberts

Publications and source records attributed to G R Roberts.

13 recordsLinked to original sources

Etiology of hearing loss and cochlear computed tomography: findings in preimplant assessment.

Patients being considered for cochlear implantation undergo, of necessity, a wide-ranging selection process, of which imaging of the temporal bone to assess cochlear patency is an important part. We have studied the correlation between the results of computed tomography (CT) imaging of the cochlea and the cause of hearing loss in this group of patients. The CT scans of 105 patients were reviewed. Of these, 74 (70%) were normal, with the commonest abnormalities being labyrinthitis ossificans in 14 (13.3%) cases and capsular rarefaction in 10 (9.5%) cases. A congenital abnormality was seen in 4 (3.8%) cases and temporal bone fractures in 2 (1.9%) cases; 1 patient had previously undergone a labyrinthectomy. In 25 patients the cause of the hearing loss was known to be meningitis. Of these patients, 15 had normal scans and 10 showed labyrinthitis ossificans. Of note is that none of the 6 patients with tuberculous meningitis had abnormal scans. There was a high correlation between a rarefied capsule on CT imaging and a diagnosis of otosclerosis, with 6 out of 7 otosclerosis patients demonstrating this abnormality. Evidence of a previous temporal bone fracture was seen on the scans of only 2 out of 6 patients in whom the cause of deafness was thought to be severe head injury.

Cochlea

Performance of a new vascular xeno prosthesis.

To date no prosthetic vascular prosthesis performs as well as the autologous saphenous vein in diameters of 6 mm and less. The purpose of this study was to compare the in vitro and in vivo performance of a new glutaraldehyde stabilized, narrow diameter (4 mm), vascular prosthesis fashioned from bovine ureters (Flonova) with the saphenous vein and polytetrafluoroethylene (PTFE) prostheses. The methods used for the comparative in vitro analysis of the bovine ureter and saphenous vein were modifications of tests recommended by the American National Standards for Vascular Prostheses. Blood compatibility was evaluated by measuring platelet consumption in an artificial circulation, and heparin uptake was quantified using tritiated heparin. The results indicate that the bovine ureter grafts have an adequate degree of mural integrity and hemocompatible properties comparable to saphenous vein. The in vivo patency in a canine bilateral femoral interposition model was 62.5% (10/16) for the bovine ureters and 43.75% (7/16) for PTFE. Bovine ureter grafts appear to have an excellent potential for use in narrow diameter peripheral and coronary arterial bypass procedures and warrant further investigation.

Animals