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Biomedical subjects

G R Monif

Publications and source records attributed to G R Monif.

At least 73 records · Page 4Linked to original sources
PubMed1978

Rubella antibody titer. The significance of low-titered rubella antibodies.

The hemagglutination inhibition (HAI) test is not mathematically precise and reproducible. Thus, it is critical to know whether or not the threshold titer (1 : 10) of detectable rubella antibody is indicative of true immunity. Three patients with a 1 : 10 HAI titer presented with subsequent rubella during gestation. Ninety postpartum patients with a HAI titer of 1 : 10 were vaccinated and the rubella antibody titers were reassessed. Seventeen percent of these patients responded to the vaccine challenge with an eightfold or greater rise in titer. Thus, we recommend that the patient with a low HAI titer (1 : 10) should be considered to have marginal immunity to rubella and should be vaccinated.

Adult↗
PubMed1977

Clinical response of patients with gonococcal endocervicitis and endometritis-salpingitis-peritonitis to doxycycline.

The clinical response to single-drug therapy with doxycycline was evaluated in 25 patients with gonococcal endoceruicitis and was correlated with the bacterial isolates present within the cul-de-sac. The 10 patients with gonococcal salpingitis salpingitis and the three patients with gonococcal peritonitis exhibited excellent clinical responses. When polymicrobial infection coexisted with gonococcal peritonitis or functioned without the concomitant presence of Neisseria gonorrhoeae, a significantly altered therapeutic response was observed in four of the 12 patients. Four patients in this grouping exhibited either secondary temperature elevations or lack of a significant alteration of the white blood cell count, two features which were not characteristic of the patients with either gonococcal salpingitis or peritonitis. In the cases of polymicrobial peritonitis, there was a poor correlation between ensuing clinical response and in vitro resistance of one or more cul-de-sac isolated to doxycycline. The presence of a resistant organism did not preclude a good or satisfactory clinical response. The absence of a resistant organism correlated well with a good clinical response.

Adolescent↗
PubMed1977

Fatal sepsis associated with an intrauterine device and pregnancy.

The 15th case of maternal death associated with sepsis in pregnancy in a patient using the Dalkon Shield intrauterine device is reported. Intrauterine sepsis appears to be a complication of the use of this device. B acteria enter the uterus during pregnancy through the multifilament tail of the device. The management of sepsis during pregnancy associated with an in situ IUD often requires a combined medical and obstetrical approach. The removal of all Dalkon Shields is strongly recomended.

Adult↗
PubMed1976

Blood as a potential vehicle for the cytomegaloviruses.

This study analyzed transfused blood as a potential vehicle for infectious cytomegalovirus (CMV) particles. A total of 207 patients who received a total number of 897 units of blood were monitored. A complement-fixing antibody titer of 1:8, as determined by micro-titer technique, was observed in 14.8 per cent of the blood units. A total of 140 individuals in this study were serosusceptible. Eighty-six serosusceptible individuals did not receive blood containing complement-fixing CMV antibodies. In this patient population three instances of seroconversion were identified. Among the 54 serosusceptible individuals who received at least one unit of blood whose complement-fixing titer to the AD-169 strain of CMV was 1:8 or greater, 13 seroconversions were observed.

Antibodies, Viral↗
PubMed1976

Cul-de-sac isolates from patients with endometritis-salpingitis-peritonitis and gonococcal endocervicitis.

Neisseria gonorrhoeae was cultured from the cul-de-sac in 11 of 17 patients with bacteriologically documented gonococcal endometritis-salpingitis and identified by Gram stain in one other instance. In five, N. gonorrhoeae was the only isolate. In six other patients, the presence of other aerobic (two) and anaerobic bacteria (three), as well as N. gonorrhoeae, was documented. In the remaining six patients, only aerobic and anaerobic organisms were isolated. The data are interpreted as supporting the concept of anaerobic superinfections following initial infection with N. gonorrhoeae late in the course of this disease entity.

Aerobiosis↗
PubMed1976

Living cytology: A new diagnostic technique for malignant pleural effusions.

The efficacy of a new tissue-culture technique for the diagnosis of malignant pleural effusions was contrasted with conventional cytologic methods. The new technique is based on the ability of the tissue-culture medium to transform mesothelial cells into fibroblasts while not sustaining lymphoreticular cells. Against a background of fibroblasts, islets of adenocarcinoma are easily identified. Of 20 patients with pleural effusions and solid tumors, the tissue-culture technique correctly diagnosed eight (40 percent), compated to seven (35 percent) for conventional cytologic methods. Of 27 pleural effusions in patients without malignant neoplasms, there was only one probable false-positive.

Adenocarcinoma↗
PubMed1976

Polymicrobial bacteremia in obstetric patients.

Thirteen cases of polymicrobial bacteremia occurring in obstetric patients are reported. The most commonly occurring combination involved the Bacteriodeaceae, anaerobic streptococci, and Hemophilus vaginalis. In 3 cases the spectrum of bacterial isolates obtained from the intravascular compartment changed significantly.

Adolescent↗
PubMed1975

Viruses as teratogens.

There is nothing unique about rubella viruses or cytomegaloviruses. They are classic teratogens and, in this respect, not only follow but exemplify most of the principles of human teratology.

Cell Differentiation↗
PubMed1975

"Living cytology" in the diagnosis of intraabdominal adenocarcinoma.

Cytologic diagnosis of adenocarcinoma metastatic to the peritoneal surface is often hampered by the difficulty of differentiating between reactive mesothelial cells and macrophages from malignant epithelial cells by light microscopy. With in vitro tissue culture technics, the fibroblastic dedifferentiation of mesothelial cells facilitates the recognition of residual neoplastic epithelial cells. Ascitic fliid from 18 patients who ultimately had histologic documentation of intraabdominal adenocarcinomatosis was studied by tissue culture technics. In 15 of the 18 patients, small islets of replicating tumor cells could be identified after the mesothelial cells had dedifferentiated into fibroblasts. With one exception the average time between collection of the specimen and recognition of adenocarcinoma was 6 days. In 14 cases, a definitive diagnosis of malignancy was made by cytologic analysis.

Abdominal Neoplasms↗