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Biomedical subjects

G R Mikhail

Publications and source records attributed to G R Mikhail.

At least 19 recordsLinked to original sources
PubMed1995

Trichoblastic fibroma. A series of 10 cases with report of a new plaque variant.

BACKGROUND: Trichoblastic fibroma is a benign trichogenic tumor that has both epithelial and mesenchymal components and exhibits partial to complete follicular induction. We studied 10 cases of trichoblastic fibroma and reviewed their clinical and histologic features. OBSERVATIONS: All 10 tumors were located on the face. Nine of 10 patients were women. The mean age at presentation was 63.8 years (range, 35 to 81 years). Two distinct subsets of trichoblastic fibroma were identified: the nodular variant and the plaque variant. The nodular variant is well circumscribed, while the plaque variant is poorly circumscribed, has significant subclinical extension, and may represent the low-grade malignant counterpart of the classic nodular trichoblastic fibroma. Histologically, both variants demonstrate mesenchymal induction with keratin cysts, papillary mesenchymal bodies, and an inductive fibroblastic stroma. CONCLUSIONS: Trichoblastic fibroma may be confused clinically and/or histologically with basal cell carcinoma. Identification of the mixed epithelial-mesenchymal components is helpful in tumor recognition. The plaque variant trichoblastic fibroma has not been previously reported. Familiarity with this variant is important because of the potential for infiltrative growth.

Adult↗
PubMed1989

Rippled-pattern trichomatricoma. Histological, immunohistochemical and ultrastructural studies of an immature hair matrix tumor.

A hair matrix tumor showing an unusual tumor cell arrangement was found at the base of a solitary trichoepithelioma. Coexisting with solid epithelial islands and immature hair follicle-like stroma resembling the Verocay bodies of neurilemmoma or "ripplemarks" on waves were found. In other areas myxomatous degeneration of the stroma changed the rippling into a cribriform pattern. In some parts of the tumor there was a dense melanin pigment associated with MEL5 stained melanocytes. S-100 and CD1 (OKT6) antigen stains demonstrated Langerhans cells scattered in the parenchyma and less frequently in the stroma. The majority of tumor cells were considered immature pilar cortical cells because of the following: 1. HKN-6 was strongly positive; 2. a large number of melanocytes were associated with tumor cells in some foci; 3. ultrastructurally immature tumor cells, which had electron-dense tonofilaments and many desmosomes, were transformed without production of trichohyalin granules into semikeratinized cells which showed nuclear degeneration and loss of electron density in tonofilaments. This tumor, however, has not attained the degree of differentiation observed in trichoblastoma (1) another example of an immature cortical cell tumor. Squamous eddy-like or horn pearl-like foci of incomplete keratinization and large keratin-filled cysts were also present within the immature parenchyma, indicating that some immature cells were differentiating toward non-cortical cells, as found in the outer sheath. We would like to designate this tumor "rippled pattern trichomatricoma", a new entity.

Adult↗
PubMed1987

Eruptive keratoacanthoma en plaque in an immunosuppressed patient.

Immunosuppressive therapy predisposes to the development of a variety of neoplasms. A 63-year-old man developed multiple eruptive epithelial tumors 15 years after renal transplantation. The tumors included what had been diagnosed as squamous cell carcinomas, Bowen's disease, and solitary and eruptive keratoacanthomas. In addition, he developed a large plaque studded with small nodules that had the histologic features of keratoacanthoma. To our knowledge, this is the first example of acquired eruptive keratoacanthoma forming a large plaque.

Humans↗
PubMed1986

Cranial invasion by basal cell carcinoma.

The direct spread of basal cell carcinoma (BCC) into the bones of the cranium takes a long period. In its early stages, it may not be detectable by radiography or computerized tomography, but can be visible as pitting during surgery. Invasion through the thickness of the calvarium due to extension of a BCC of the scalp, or involvement of the cribriform plate by spread from an intranasal lesion, is serious. Examples of cranial invasion by BCC are presented. The methods used in diagnosis and treatment are outlined.

Aged↗
PubMed1986

Psoriasis: disease of epidermis or dermis?

Psoriasis is considered a disease of the epidermis. Two lesions of basal cell carcinoma in patches of psoriasis were excised by Mohs microscopically controlled surgery. As healing occurred by second intention, reepithelization of the surface must have taken place from the surface epidermis of the surrounding psoriatic skin. The scarred areas remained free of psoriasis for many years. This emphasizes the role of a dermal factor in the development of psoriasis.

Aged↗
PubMed1986

Spontaneous regression of metastatic malignant melanoma.

Spontaneous regression of metastatic malignant melanoma is rare. A case is presented here. The primary lesion, a lentigo maligna melanoma of the face, recurred after excision and metastasized to the parotid and upper cervical lymph nodes, and to the lungs. The patient declined further therapy. There was no clinical or radiologic evidence of metastasis 1 year later.

Aged↗
PubMed1986

Metastatic basal cell carcinoma.

Metastatic basal cell carcinoma (BCC) is rare and the cutaneous lesions in such cases are long-standing and grossly neglected. In order to establish the diagnosis, certain criteria have to be satisfied. A case of BCC of the scalp that metastasized to the lungs is here reported.

Adult↗
PubMed1986

Erosive adenomatosis of the nipple.

Erosive adenomatosis of the nipple is a benign lesion that clinically mimics Paget's disease of the nipple but has the histologic features of syringocystadenoma papilliferum. Some cases have been mistaken for intraductal papilloma or well-differentiated adenocarcinoma, and unnecessary mastectomies have been performed. Recognition of this lesion is important because it is benign and conservative excision is curative.

Adenoma, Sweat Gland↗
PubMed1986

Hutchinson's sign.

Hutchinson's sign--pigmentation of the periungual tissues--is a valuable clue to the diagnosis of subungual melanoma. When present, this sign indicates malignant melanoma, however minimal the pigmentation or the histology may be. An illustrative case is presented.

Female↗
PubMed1986

Squamous cell carcinoma in hemangioma of lip.

A deeply invasive squamous cell carcinoma of the right vermilion border of the lip superposed on a nevus flammeus (port-wine stain) was excised by the Mohs micrographic surgery, fixed-tissue technique. The course was uneventful and the final cosmesis was good.

Carcinoma, Squamous Cell↗
PubMed1986

Reinforcement of surgical adhesive strips.

Surgical adhesive strips are often used for closure of some wounds or to minimize tension on sutures after closures. The package insert of the type most commonly used (Steri-Strip), indicates that the application of compound tincture of benzoin, U.S.P. (CTB) increases strip adhesion. The increase in adhesive power by CTB was compared with a preparation containing gum mastic (Mastisol). The study clearly demonstrated that the latter preparation provided a markedly more adhesive strength than that obtained with CTB.

Adhesiveness↗
PubMed1985

Subungual basal cell carcinoma.

Subungual basal cell carcinoma is rare. Only eight cases, all involving fingers, are on record. Two additional cases are reported in this paper. One lesion was on a toe, the only one observed at this site. As the lesion may simulate a number of conditions, most of which are benign, the importance of obtaining a biopsy from a recalcitrant lesion of the nail organ cannot be overemphasized.

Adult↗
PubMed1984

Subungual epidermoid carcinoma.

Subungual Bowen's disease and squamous cell carcinoma are not as rare as has been implied by earlier literature. The course of the lesions is protracted. Clinically the diseases may mimic onychomycosis, chronic paronychia, eczema, verruca vulgaris, pyogenic granuloma, subungual exostosis, or malignant melanoma. Histologic examination is the key to diagnosis. As only two metastases have occurred in 110 patients, subungual epidermoid carcinomas should be regarded as low-grade malignancies that can be managed by conservative surgical ablation. The microscopically controlled excision technic (Mohs chemosurgery) is ideal for these tumors. Amputation of the affected digit is too drastic, especially when the thumb, the most common site, is involved.

Adult↗
PubMed1982

Basal cell carcinoma in seborrheic keratosis.

The development of basal cell carcinoma (BCC) in seborrheic keratosis (SK) is rare. Review of over 10,000 biopsies from SK revealed fourteen such cases. The material showed BCC in direct connection with the epidermis of the SK in eleven cases. In three cases the BCC was situated in the reticular dermis. A lesion with the clinical features of SK should be examined histologically when it appears inflamed, when it bleeds, or when it is crusted, eroded, or ulcerated.

Aged↗
PubMed1981

Erythroplasia (Queyrat) of conjunctiva.

Erythroplasia of Queyrat (EQ) is an epidermoid carcinoma in situ which is histologically identical with Bowen's disease of the skin but involves mucosal surfaces. The lesion is known to occur on the glans penis, the vulva, and the oral mucosa. Two cases of EQ of the conjunctiva that developed several years after radiotherapy for basal cell carcinoma of the eyelids are here reported. The signs and symptoms closely mimicked those of chronic conjunctivitis. The lesions were excised by the microscopically controlled excision of Mohs. It is recommended that biopsy material be obtained in patients who develop a nonresolving chronic conjunctivitis, especially when there is history of radiotherapy of the eyelids.

Carcinoma in Situ↗
PubMed1981

Multifocal basal-cell carcinomas in the Nevus sebaceus of Jadassohn.

A lesion of nevus sebaceus with multifocal basal-cell carcinomas was excised by Mohs' fresh-tissue technique. Histologically, most of the foci of basal-cell carcinomatosis were of the superficial type, but the few more deeply situated foci had adamantinoid features. The malignancies extended well beyond the clinically discernible margins of the nevus sebaceus. Spontaneous healing of the wound of ablation resulted in a satisfactory appearance.

Basal Cell Carcinoma↗