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Biomedical subjects

G R Jones

Publications and source records attributed to G R Jones.

At least 163 records · Page 9Linked to original sources
PubMed1977

The in vitro metabolism of 2-nitroso-1-phenylpropane dimer by fortified 9000g supernatants from rabbit liver.

2-Nitroso-1-phenylpropane dimer, a postulated metabolic product of amphetamine, was metabolized by fortified 9000 g supernatants from rabbit liver, mainly by oxidation on the carbon beta to the nitrogen to form a "beta-hydroxylated nitroso dimer'. The corresponding nitro compound, ketone and alcohol were also products, the latter two but not the former being cofactor dependent. The nitroso compound was not metabolically reduced under the conditions used.

Amphetamine↗
PubMed1977

Metabolic oxidation of aralkyl oximes to nitro compounds by fortified 9000g liver supernatants from various species.

Incubation of 'amphetamine oxime' (IIa, anti-benzyl methyl ketoxime) with fortified rabbit liver 9000 g supernatants gave the nitro compound (Ie) and the beta-hydroxylated oxime (IIc) in addition to the previously reported ketone (IIb) and alcohol (Ic) metabolites. Formation of the products was cofactor dependent. The nitro compound was also formed using mouse, hamster and guinea-pig 9000 g liver supernatants and to a minor extent by rat liver. The oximes of 2-phenethylamine (IIe) and norfenfluramine (IIg) were also metabolized to the corresponding nitro compounds, ketones and alcohols with rabbit 9000 g liver supernatants; however, no nitro compound (IIIb) was detected after the incubation of 'mexiletine oxime' (IVa). The metabolic products were identified and characterized by g.l.c., t.l.c. and g.l.c. linked mass spectrometry by comparison with synthetic materials.

Amphetamines↗
PubMed1977

Observations on the use of the double diffusion test in the diagnosis of vaginal candidiasis.

Precipitins to mannan and cytoplasmic antigens of three Candida species were determined in an unselected series of 289 non-pregnant women. Precipitins were present in 20% of sera of women with vaginal candidiasis, in 23% of women harbouring yeasts in the vagina without clinical signs of infection, and in 21% of women harbouring yeasts in sites other than the vagina. Of the 47 patients who reacted with Candida albicans mannan or cytoplasmic antigens, 98% reacted with mannan antigen but only 13% with cytoplasmic antigen. The inclusion of mannan and cytoplasmic antigens of C. guilliermondii and C. parapsilosis did not increase the specificity or sensitivity of the test in the diagnosis of vaginal candidiasis. It is suggested that the double diffusion test is of doubtful value as an adjunct to the diagnosis of vaginal candidiasis.

Adolescent↗
PubMed1975

Antigenic analysis of yeast cell-walls.

Agglutination and complement fixation tests with yeast cell-walls revealed an extensive and complex pattern of cross-reactions amongst 26 species of 20 genera of yeasts. Common antigens were found in all yeast cell-walls. Ascosporogenous yeasts possessed antigens not found in the asporogenous yeasts and vice versa. Nuberical analyses of serological properties confirmed this distinction and also that little differentiation could be achieved at generic level with respect to Saccharomyces and Candida spp.

Agglutination Tests↗
PubMed1975

A comparison of analytical methods for the numerical taxonomy of yeasts.

Four methods of numerical analysis were tested to assess the taxonomic relationships of species of yeasts in 20 genera using characters obtained from standard descriptions. Relationships varied according to the analytical method employed. It is suggested that a reduction in the present number of genera may be necessary to justify the taxonomic rank of genus.

Candida↗
PubMed1975

Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen.

A double-blind trial of 2% miconazole in a cream and in a powder base and of the respective vehicles was done in a group of forty-five young sportsmen regularly training and using the showers in a gymnasium. After 4 weeks treatment, the mycological cure rate using the active preparation was 60% compared to 24% for the placebo (P less than 0-05).

Adult↗
PubMed1975

An "air-cart" for scintillation camera positioning.

An air-cart that operates on the laminar air flow principle was designed to permit easy movement of a scintillation camera detector by one operator. Air flow is obtained from the hospital main supply which is available to each room.

Air↗
PubMed1975

Myocarditis associated with Mycoplasma pneumoniae infection.

A 48-year-old patient presented with pneumonia and pleural effusion due to Mycoplasma pneumoniae, and subsequently developed pharyngitis and electrocardiographic evidence of myocarditis. The sparse literature on mycoplasma myocarditis is reviewed. The clinical features, electrocardiographic changes and prognosis are discussed.

Animals↗
PubMed1974

Control of tinea pedis in a swimming bath.

Random samples of the weekly entry of bathers to a swimming pool were examined for tinea pedis and verruca before and at intervals after the supply of individual sachets of foot powder to all bathers.Over three and a half years the overall incidence of tinea pedis decreased from 8.5% to 2.1%, and in adult males it decreased from 21.5% to 6.9%. The incidence of infection with Trichophyton mentagrophytes var. interdigitale decreased from 5.3% to 0.5%, and the incidence of infection with T. rubrum (1.2%-1.1%) and Epidermophyton floccosum (0.9%-0.5%) did not change significantly. The incidence of verruca decreased from 4.8% to 1.2%. Issuing foot powder clearly minimizes the spread of infection and is recommended for general use.

Administration, Topical↗